The influence of pyrimidine nucleoside phosphorylase activity on metastasis of breast cancer

  • Authors:
    • T Hideshima
    • J Yamashita
    • T Maekawa
    • T Sakai
    • M Baba
    • M Ogawa
    • T Shirakusa
  • View Affiliations

  • Published online on: July 1, 1997     https://doi.org/10.3892/or.4.4.795
  • Pages: 795-798
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Abstract

The activity of pyrimidine nucleoside phosphorylase (PyNPase) was analyzed in thirty-six cases of resected breast cancer and 9 cases of resected benign breast tumor. PyNPase is an enzyme which converts 5'-DFUR to 5-FU in tumor tissue and has been reported to be identical to the platelet-derived endothelial cell growth factor (PD-ECGF) that has angiogenic activity. PyNPase activity was significantly elevated in cancer and metastatic lymph nodes compared to normal lesions of the same breast. PyNPase activity was higher in T2 and T3 breast cancer than of T1 breast cancer. Furthermore, cases of high PyNPase activity (>200 mu g FU/mg protein/h) were significantly more likely to develop distant metastasis (p<0.01) than those of low PyNPase activity. These results suggest an important role of PyNPase activity in the progression of breast cancer.

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July 1997
Volume 4 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hideshima T, Yamashita J, Maekawa T, Sakai T, Baba M, Ogawa M and Shirakusa T: The influence of pyrimidine nucleoside phosphorylase activity on metastasis of breast cancer. Oncol Rep 4: 795-798, 1997
APA
Hideshima, T., Yamashita, J., Maekawa, T., Sakai, T., Baba, M., Ogawa, M., & Shirakusa, T. (1997). The influence of pyrimidine nucleoside phosphorylase activity on metastasis of breast cancer. Oncology Reports, 4, 795-798. https://doi.org/10.3892/or.4.4.795
MLA
Hideshima, T., Yamashita, J., Maekawa, T., Sakai, T., Baba, M., Ogawa, M., Shirakusa, T."The influence of pyrimidine nucleoside phosphorylase activity on metastasis of breast cancer". Oncology Reports 4.4 (1997): 795-798.
Chicago
Hideshima, T., Yamashita, J., Maekawa, T., Sakai, T., Baba, M., Ogawa, M., Shirakusa, T."The influence of pyrimidine nucleoside phosphorylase activity on metastasis of breast cancer". Oncology Reports 4, no. 4 (1997): 795-798. https://doi.org/10.3892/or.4.4.795