Expression of variant CD44, exon 6 in patients with metastatic pulmonary tumor

  • Authors:
    • A Iwasaki
    • K Tashiro
    • M Kuwahara
    • D Matsuzoe
    • K Okabayashi
    • T Shiraishi
    • K Kawahara
    • T Shirakusa
  • View Affiliations

  • Published online on: July 1, 1997     https://doi.org/10.3892/or.4.4.815
  • Pages: 815-818
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

High expression ratios of CD44 variant 6 (CD44 V6) in patients with metastatic pulmonary tumor were found in those with primary lesions of cancer of the colon, uterus, larynx, liver and osteosarcoma. It was clarified that patients showing expression of CD44 variant 6 likely revealed pulmonary metastasis at earlier time following operations of primary cancer (p<0.05). CD44 V6, an adhesion molecule, was a factor to participate in pulmonary metastases from various organ cancers. No significant correlation was observed in survival between patients with CD44 V6 positive versus negative tumors, except laryngeal tumor after resection of primary or metastatic lung tumor. CD44 V6 related to its invasive and further metastatic functions in metastatic lung tumor. We suggest that cancer cells expressing the CD44 molecule especially V6 may adhere to vascular endothelium and hyaluronic acid in the lung. And cancer cells without this molecule liberated from the primary focuses hardly adhere to the pulmonary tissues supposedly resulting in delayed metastases and proliferations in the pulmonary tissues.

Related Articles

Journal Cover

July 1997
Volume 4 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Iwasaki A, Tashiro K, Kuwahara M, Matsuzoe D, Okabayashi K, Shiraishi T, Kawahara K and Shirakusa T: Expression of variant CD44, exon 6 in patients with metastatic pulmonary tumor. Oncol Rep 4: 815-818, 1997
APA
Iwasaki, A., Tashiro, K., Kuwahara, M., Matsuzoe, D., Okabayashi, K., Shiraishi, T. ... Shirakusa, T. (1997). Expression of variant CD44, exon 6 in patients with metastatic pulmonary tumor. Oncology Reports, 4, 815-818. https://doi.org/10.3892/or.4.4.815
MLA
Iwasaki, A., Tashiro, K., Kuwahara, M., Matsuzoe, D., Okabayashi, K., Shiraishi, T., Kawahara, K., Shirakusa, T."Expression of variant CD44, exon 6 in patients with metastatic pulmonary tumor". Oncology Reports 4.4 (1997): 815-818.
Chicago
Iwasaki, A., Tashiro, K., Kuwahara, M., Matsuzoe, D., Okabayashi, K., Shiraishi, T., Kawahara, K., Shirakusa, T."Expression of variant CD44, exon 6 in patients with metastatic pulmonary tumor". Oncology Reports 4, no. 4 (1997): 815-818. https://doi.org/10.3892/or.4.4.815