Relationship between matrix metalloproteinase expression and tumor angiogenesis in human breast carcinoma.

  • Authors:
    • T Kurizaki
    • M Toi
    • T Tominaga
  • View Affiliations

  • Published online on: May 1, 1998     https://doi.org/10.3892/or.5.3.673
  • Pages: 673-680
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Intratumoral proteases are known to be involved in not only tumor cell invasion but also a variety of stromal reactions including neovascularization. In this study, we have examined the expression of matrix metalloproteinases (MMPs) by gelatin gel zymography and compared its expression with angiogenesis activities including the expression of several endothelial growth regulators and intratumoral microvessel density (MVD) in human breast cancer tissues. There was a significant correlation between activated MMP-2 expression and vascular endothelial growth factor (VEGF) expression (p=0.045). In addition, the expression of activated MMP-9 expression was significantly correlated with thymidine phosphorylase (TP) expression (p=0.0044). Pro MMP-9 expression tended to correlated with the increment of MVD (p=0.063). MMP-2 and MMP-9 expressions were frequently co-upregulated with endothelial growth regulators in human breast cancer tissues, which underlines the cooperative function of MMPs in neovascularization.

Related Articles

Journal Cover

May-Jun 1998
Volume 5 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Kurizaki T, Toi M and Tominaga T: Relationship between matrix metalloproteinase expression and tumor angiogenesis in human breast carcinoma.. Oncol Rep 5: 673-680, 1998
APA
Kurizaki, T., Toi, M., & Tominaga, T. (1998). Relationship between matrix metalloproteinase expression and tumor angiogenesis in human breast carcinoma.. Oncology Reports, 5, 673-680. https://doi.org/10.3892/or.5.3.673
MLA
Kurizaki, T., Toi, M., Tominaga, T."Relationship between matrix metalloproteinase expression and tumor angiogenesis in human breast carcinoma.". Oncology Reports 5.3 (1998): 673-680.
Chicago
Kurizaki, T., Toi, M., Tominaga, T."Relationship between matrix metalloproteinase expression and tumor angiogenesis in human breast carcinoma.". Oncology Reports 5, no. 3 (1998): 673-680. https://doi.org/10.3892/or.5.3.673