Enhancement of immunohistochemical reactivity for thymidine phosphorylase in breast carcinoma cells after administration of docetaxel as a neoadjuvant chemotherapy in advanced breast cancer patients.

  • Authors:
    • M Kurosumi
    • T Tabei
    • K Suemasu
    • K Inoue
    • T Kusawake
    • N Sugamata
    • Y Higashi
  • View Affiliations

  • Published online on: September 1, 2000     https://doi.org/10.3892/or.7.5.945
  • Pages: 945-953
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

For the purpose of demonstrating possible effects of docetaxel on thymidine phosphorylase (TP) activity in human breast carcinoma, we examined breast carcinoma tissues pre- and post-administration of docetaxel, by an immunohistochemical method using an anti-TP monoclonal antibody. Eight patients with advanced breast carcinoma were initially treated with 3 cycles of 60 mg/m2 of docetaxel once every 3 weeks after incisional biopsy of tumors, and following 3 cycles of docetaxel, they underwent mastectomy with axillary dissection. Grades of immunohistochemical reactivity for TP of carcinoma cells in pre- and post-treatment specimens were compared. Five biopsy specimens (62.5%) were positive for TP. After administration of docetaxel, 6 of 8 cases (75.0%) revealed significant enhancement of reactivity for TP. Increased reactivity was recognized diffusely as well as focally in carcinoma tissues. From these results, we believe that administration of docetaxel to breast cancer patients evokes enhancement of immunohistochemical reactivity for TP in breast carcinoma cells in situ. Furthermore, we consider that docetaxel treatment might improve efficacy of additional doxifluridine and capecitabine therapy.

Related Articles

Journal Cover

Sep-Oct 2000
Volume 7 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Kurosumi M, Tabei T, Suemasu K, Inoue K, Kusawake T, Sugamata N and Higashi Y: Enhancement of immunohistochemical reactivity for thymidine phosphorylase in breast carcinoma cells after administration of docetaxel as a neoadjuvant chemotherapy in advanced breast cancer patients.. Oncol Rep 7: 945-953, 2000
APA
Kurosumi, M., Tabei, T., Suemasu, K., Inoue, K., Kusawake, T., Sugamata, N., & Higashi, Y. (2000). Enhancement of immunohistochemical reactivity for thymidine phosphorylase in breast carcinoma cells after administration of docetaxel as a neoadjuvant chemotherapy in advanced breast cancer patients.. Oncology Reports, 7, 945-953. https://doi.org/10.3892/or.7.5.945
MLA
Kurosumi, M., Tabei, T., Suemasu, K., Inoue, K., Kusawake, T., Sugamata, N., Higashi, Y."Enhancement of immunohistochemical reactivity for thymidine phosphorylase in breast carcinoma cells after administration of docetaxel as a neoadjuvant chemotherapy in advanced breast cancer patients.". Oncology Reports 7.5 (2000): 945-953.
Chicago
Kurosumi, M., Tabei, T., Suemasu, K., Inoue, K., Kusawake, T., Sugamata, N., Higashi, Y."Enhancement of immunohistochemical reactivity for thymidine phosphorylase in breast carcinoma cells after administration of docetaxel as a neoadjuvant chemotherapy in advanced breast cancer patients.". Oncology Reports 7, no. 5 (2000): 945-953. https://doi.org/10.3892/or.7.5.945