Correlation of DNA synthesis-inhibiting activity and the extent of transmembrane permeation into tumor cells by unsaturated or saturated fatty alcohols of graded chain-length upon hyperthermia

Takada,Yoshie; Kageyama,Katsuhiro; Yamada,Ryusaku; Onoyama,Yasuto; Nakajima,Toshibumi; Hosono,Masako; Miwa,Nobuhiko

doi:10.3892/or.8.3.547

May-June 2001 Volume 8 Issue 3

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May-June 2001 Volume 8 Issue 3

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Article

Correlation of DNA synthesis-inhibiting activity and the extent of transmembrane permeation into tumor cells by unsaturated or saturated fatty alcohols of graded chain-length upon hyperthermia

Authors:
- Yoshie Takada
- Katsuhiro Kageyama
- Ryusaku Yamada
- Yasuto Onoyama
- Toshibumi Nakajima
- Masako Hosono
- Nobuhiko Miwa
View Affiliations / Copyright

Affiliations: Department of Radiology, Osaka City University Medical School, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
Pages: 547-551
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Published online on: May 1, 2001

https://doi.org/10.3892/or.8.3.547
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Abstract

The carcinostatic activity has been studied for fatty acids of diverse species but scarcely for fatty alcohols. Three unsaturated fatty alcohols at 35-50 μM inhibited DNA synthesis and the proliferation of tumor cells by a combination with hyperthermia to greater extents in the order: oleyl (C18:1)-> linoleyl (C18:2)-> α-linolenyl (C18:3) alcohol, which is an order inverse to that known for the corresponding fatty acids (4). In contrast, two saturated fatty alcohols, palmityl (C16:0)- and stearyl (C18:0) alcohols, did not inhibit at the same concentrations. At 100 μM, palmityl alcohol inhibited, whereas stearyl alcohol did not. The effective fatty alcohols appreciably permeated the cells. The inhibition of the unsaturated fatty alcohols on DNA synthesis and proliferation was nearly proportional to the amount of their intercellular accumulation at 37°C or 42°C; the most inhibitory, oleyl alcohol, was the most membrane-permeable, whilst inversely the least inhibitory, α-linolenyl alcohol, was the least permeable. A proportional correlation was not observed for saturated fatty alcohols; palmityl alcohol underwent an approximate 2-fold more abundant accumulation than other fatty alcohols, but was weakly inhibitory. Thus, oleyl alcohol may exert an antitumor action via appropriately efficient transmembrane permeation and a combination with hyperthermia.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Correlation of DNA synthesis-inhibiting activity and the extent of transmembrane permeation into tumor cells by unsaturated or saturated fatty alcohols of graded chain-length upon hyperthermia

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