ETM Experimental and Therapeutic Medicine 1792-0981 1792-1015 D.A. Spandidos 10.3892/etm.2020.8445 ETM-0-0-8445 Articles Clinical outcomes of blood transfusion to patients with pelvic fracture in the initial 6 h from injury YangQing 1 * WangTing 2 * AiLei 3 JiangKai 1 TaoXingguang 1 GongDongliang 1 ChenNong 1 FuYang 1 PanFugen 1 Department of Orthopedics, QingPu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital of Shanghai, Shanghai 201700, P.R. China Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 201600, P.R. China Department of Laboratory, Taishan Coal Sanatorium, Taian, Shangdong 201700, P.R. China Correspondence to: Dr Yang Fu or Dr Fugen Pan, Department of Orthopedics, QingPu Branch of Zhongshan Hospital Affiliated to Fudan University, Qingpu District Central Hospital of Shanghai, 1158 East Gongyuan Road, Qingpu, Shanghai 201700, P.R. China, E-mail: fu255@126.com, E-mail: panfugen123@126.com

Contributed equally

 03 2020 10 01 2020 19 3 2252 2258 18052019 02122019 Copyright: © Yang et al. 2020 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

As part of the treatment of pelvic fracture, major hemorrhage poses a challenge for trauma surgeons. The aim of the present study was to evaluate the clinical outcomes of blood transfusion in the initial 6 h after pelvic fracture, and to define the blood transfusion volume required for each pelvic fracture type. A retrospective cohort study was performed on patients with pelvic fracture at a single Level I Trauma Centre over a 3-year period. A total of 1,297 patients were transported to our trauma centre within 2 h of injury and blood transfusion was administered in the initial 6 h after pelvic fracture. Review of the patients' medical records provided the initial pelvic radiographs and data from emergency department care. Clinical outcomes, including frequency of blood transfusion, blood transfusion volume, injury severity scores and mortality, were evaluated. All pelvic fractures were defined as closed fractures and patients were categorized according to the Arbeit fuer Osteosynthese (AO) classification system. Statistical methods were used to identify trends to provide guidance for clinical prediction. Complete data were available for 497 patients with pelvic fracture, 104 (20.9%) of which received blood transfusion. The blood transfusion volume in the initial 6 h ranged from 0 to 10,000 ml, with a mean of 1,213.94±1354.11 ml. The total mortality rate was 1.8%. Among the patients with C-type pelvic fractures, the frequency of blood transfusion was 59.0% and the mean volume was 2,191.30±1,740.93 ml. The mortality rate for C-type pelvic fractures was 11.43%. The B3 subtype of pelvic fractures had the highest transfusion frequency (53.6%), while the C3 subtype had the largest blood transfusion volume (5,700.00±4,666.90 ml). Patients with type A-C pelvic fractures had a progressively larger mean transfusion volume, transfusion frequency and mortality in the initial 6 h after pelvic fracture. The AO classification system was demonstrated to be a useful tool for the identification of pelvic fracture risk in the present study.

 pelvic fracture hemorrhage transfusion prediction rule Introduction

Selection of the optimal treatment of major hemorrhage in patients with pelvic fracture remains a challenge for trauma surgeons (1–7). Uncontrollable major hemorrhage is a major cause of mortality in patients with pelvic fractures (8–11). Relatively aggressive measures are imperative to manage this serious pathophysiological status; blood transfusion is an effective protocol for the improvement of the hypovolemic status and the use of other supportive care measures, including external fixations, angiography and embolization, as well as pre-peritoneal pelvic packing, may also be effective (8–11). Previous studies have revealed that high-energy pelvic fracture is associated with a relatively higher blood transfusion frequency (12–14). These studies reported that blood transfusion is required at 24 (12), 48 (14) or 72 h (13). The Young and Burgess classification system (3) has been used to indicate the requirement for blood transfusion. However, blood transfusion administered in the initial 6 h after pelvic fracture is essential for the emergency treatment of pelvic fracture, which may improve the hypovolemic status immediately and decrease predictable mortality and morbidity. In addition, the Arbeit fuer Osteosynthese (AO) classification (15) of pelvic fractures has not been well investigated with regard to the blood transfusion volume. Type A is defined as a stable pelvic fracture, type B as rotationally unstable and type C as rotationally and vertically unstable fracture.

The aim of the present study was to evaluate the clinical outcomes of pelvic fracture and determine the blood transfusion volume required in the initial 6 h in association with the pelvic fracture type. The AO classification system was used to categorize patients into pelvic fracture subgroups and determine any association with blood transfusion. These results will help guide transfusion requirements and identify the optimal treatment for patients in the initial 6 h after pelvic fracture.

 Patients and methods <sec> <title>Patients

Patients with pelvic fractures admitted to a Level I Trauma Centre in the Qingpu Branch of Zhongshan Hospital affiliated to Fudan University (Shanghai, China) between January 2014 and December 2016 were retrospectively identified using CT scanning images from the Emergency Registry of the Qingpu Branch of Zhongshan Hospital affiliated to Fudan University (Shanghai, China). Demographic data, abbreviated injury scale (16), injury severity score (ISS) (17) and blood transfusion requirements in the initial 6 h after presentation of patients with pelvic fracture to the trauma centre were recorded.

Closed pelvic fractures were included in the present study. Open pelvic fractures, pediatric pelvic fractures and severe soft tissue injuries were excluded. Additionally, patients with major internal bleeding, severe illness (hypertension, heart disease and diabetes mellitus) and abnormal coagulation diseases were excluded to diminish their influence on the investigation. Complete data were available for 497 patients with pelvic fracture. Mortality was defined as the proportion of deaths among patients with different types of pelvic fractures, whilst the morbidity was defined as the proportion of patients with pelvic fractures out of all trauma cases (1297) who were transported to the trauma center within 2 h of injury.

 Radiographic classification

Patients were subjected to radiological examination according to the guidelines of Advanced Trauma Life Support (18). CT scanning was performed using a 64-slice multidetector CT scanner with automated tube current modulation (Lightspeed 64VCT; GE Healthcare) to determine the pelvic fracture type and other body system injuries on radiographs. A fellowship-trained orthopedic traumatologist with >10 years of experience and the institution's primary surgeon retrospectively classified the fractures according to the AO classification system.

 Blood transfusion and emergency measures

The indications for blood transfusion for pelvic fracture patients are systolic blood pressure of <90 mmHg, heart frequency >130 bpm and clinical symptoms of shock. In an emergency, combined transfusion of red blood cells, plasma and platelets (6-4-1) is preferred (19). A baseline blood sample is collected prior to blood transfusion. A pelvic belt is used for pre-hospital care. Focused assessment with sonography for trauma (FAST) (20) ultrasound is used to detect free intraperitoneal effusion in B- and C-type pelvic fractures. A positive FAST examination should be followed by laparotomy when indicated, for further investigation of the abdominal injuries and hemorrhage. External fixations are used to control the rotationally unstable pelvic fractures in the emergency room. Angiography and embolism are useful for patients with arterial injuries and pre-peritoneal pelvic packing may be an effective measure for patients with combined abdominal injury and require emergency laparotomy.

 Statistical analysis

The Kruskal-Wallis test was used to compare the volume of blood transfusion among pelvic fracture types. The frequency of blood transfusion was compared using a χ2 test for categorical variables and one-way ANOVA followed by Student-Newman-Keuls post hoc test were applied for continuous variables. Statistical analysis was performed using SAS version 9.1 (SAS Institute). P<0.01 was considered to indicate a statistically significant difference.

 Results <sec> <title>General data

Complete data were available for 497 patients with pelvic fracture (Table I). The mean age of the patients included in the study was 32±16.5 years (range, 18–48 years) and 276 patients were male (55.5%), while 203 patients were female (44.5%). The mechanism of injury was high-energy impact, including traffic collision and fall from height. In the present study, 31 patients had a systolic blood pressure of <90 mmHg, accounting for 6.2% of all cases, and 44 patients had a heart frequency of >130 beats per min, accounting for 8.9% of all cases. A total of 104 (20.9%) patients received blood transfusion, with a blood transfusion volume range of 0–10,000 ml in the first 6 h (mean, 1,213.94±1,354.11 ml).

 Blood transfusion

The mean blood transfusion volume was 437.76±282.02 ml for type A, 1,603.13±1,203.28 ml for type B and 2,191.30±1,740.93 ml for type C pelvic fractures (Table II). The Kruskal-Wallis test was used to compare the blood transfusion volume among pelvic fracture types. The results indicated a larger mean blood transfusion volume in patients with C-type pelvic fractures as compared with that in the other types (χ2=46.6789, degrees of freedom, F=2; P<0.01; Fig. 1).

The distribution of the blood transfusion volume in each pelvic fracture type was explored. There were 51 patients with a transfusion volume of <600 ml (49.0%), 23 (22.1%) with a transfusion volume of 600–1500 ml and 30 (28.9%) with a transfusion volume of >1,500 ml (Table III). The frequency of blood transfusion in the three pelvic fracture types was determined using the χ2 test. The results indicated that patients with C-type pelvic fractures were significantly more likely to require a blood transfusion (59.0%) than patients with A and B types (12.4 and 50.1%, respectively; F=4, χ2=56.9067, P<0.01). Massive blood transfusion was defined as >1,500 ml and compared among the groups using the χ2 test. The results indicated that patients with C-type pelvic fractures were significantly more likely to require massive blood transfusion (F=2, χ2=39.7562, P<0.0001).

Patients with pelvic fracture were classified into subtypes according to the AO classification system. The blood transfusion volume in the subtypes was compared. The B3 subtype was indicated to have the highest transfusion frequency, followed by the C3, C1, B2 and C2 subtypes (Fig. 2). Statistical analysis was not performed due to the limited numbers of subtypes. The mean transfusion volume for the C3 subtype was the largest, followed by the B1, C2, C1, B3 and B2 subtypes (Table IV).

Comparison of the ISS among the pelvic fracture types was performed using the Kruskal-Wallis test (Table V). It was indicated that the ISS in the C-type pelvic fracture group was higher than that for types A and B (χ2=106.8412, F=2, P<0.01).

A total of 23 of the 63 patients with B-type pelvic fractures (36.5%) and 20 of the 39 patients with C-type pelvic fractures (51.3%) had a positive FAST result (Table I). A positive FAST examination should be followed by laparotomy when indicated, in order to further investigate the abdominal injuries and hemorrhage (20). External fixation was used in 96 patients, angiography was performed to identify arterial hemorrhage and embolism in 9 patients with pelvic fractures. Pre-peritoneal pelvic packing was performed in 5 patients to treat venous hemorrhage. In addition, 150/497 (30.2%) of fracture patients were hospitalized (mean stay, 18±6.5 days) and 59 were admitted to the intensive care unit (ICU; mean stay, 9±7.3 days). Comparison of the hospital and ICU days among the pelvic fracture types was performed using Kruskal-Wallis tests (Table VI). The mean hospital stay was found to be 10±2.0 days in type A (69, 17.5%), 14±4.1 days in type B (42, 66.7%), and 24±3.8 days in type C (39, 100%). The mean ICU stay was found to be 7±5.2 days in type B (24, 38.1%) and 16±4.7 days in type C (35, 89.7%). The results indicated that the number of days of stay at the hospital and at the ICU of the C-type pelvic fracture group were higher than those for types A and B (P<0.01). A total of 18 patients contracted an infection, all of which were treated with antibiotics and debridement. The infection was cured in all patients. A total of 12 patients with pelvic fracture eventually suffered disability of varying degrees.

 Mortality and morbidity

A total of 9 patients died in the present study, 4 of which were categorized as type B, 4 as type C and 1 as type A. The overall mortality rate in the present cohort was 1.8%. The 9 patients who died had suffered multiple injuries, including head (n=3), thoracic (n=3), abdominal (n=2) spinal (n=2) and limb injury (n=2). High ISS were observed in those patients (mean ISS, 29). The mean volume of blood transfusion was 1,816 ml in the initial 6 h for patients who died; specifically, it was 1,200 ml in type A, 1,686 ml in type B and 2,100 ml in type C (Table VII).

The association between mortality and pelvic fracture type was determined using the χ2 test (Table VII). The mortality of each pelvic fracture type was 0.3% (1/395) for type A, 6.3% (4/63) for type B and 10.3% (4/39) for type C. The results suggested that the mortality in type C was higher than that in types A and B (F=2, χ2=28.3328, P<0.0001).

The morbidity of each pelvic fracture type was 30.5% (395/1,297) for type A, 4.8% (63/1,297) for type B and 3.0% (39/1,297) for type C. Comparison of the morbidity among the pelvic fracture types was performed using the χ2 test. The results suggested that the morbidity in type A was higher than that in B and C (P<0.01).

 Discussion

The clinical data provided in the present study revealed that the blood transfusion frequency and volume increased with the severity of pelvic ring disruptions. The B3 subtype with injuries in the bilateral sacroiliac joints had the highest transfusion frequency, while the C3 subtype with severe displacement of pelvic fracture received the largest blood transfusion volume.

High-energy impact of the anterior pelvic ring changes the volume of the pelvis and pressure status, resulting in major hemorrhage (5,11,13,21–23). A vertical displacement of the pelvic fracture is likely to lead to vessel ruptures (5,8,22,24). Previous studies have reported the clinical outcomes of blood transfusion in pelvic fracture patients and attempted to associate the requirement for, frequency and volume of blood transfusion with the pelvic fracture type (1–5,9,13,14,21,22). The Young and Burgess classification system is used to determine the requirement for blood transfusion. The anteroposterior compression (APC II and III) and lateral compression (LC III) types have been indicated to require a higher blood transfusion volume and be associated with high mortality (3,5,8,12,22). On the contrary, certain studies have been unable to demonstrate that pelvic fracture types comprise a clinical predictor of blood transfusion volume and frequency (4,21,25). Magnussen et al (12) reported that nearly 50% (10/25) of APC II and III or LC III injuries require significant blood transfusion (3.5–12.0 units) in the first 24 h after injury. Furthermore, patients with an APC III-type pelvic fracture had a transfusion frequency of 61% and transfusion volume of 12.6 units. Hamill et al (22) reported on 76 patients transfused with 6 or more units of blood in the first 24 h. The mean blood transfusion requirement in the first 6 h from injury was 14 units in embolized and 8 units in non-embolized patients. Transfusion frequencies of 30–55% have been reported (12,13,22); in the present study, the transfusion frequency was 20.6%, which was close to that reported by Blackmore et al (13). Burgess et al (3) determined a progressively larger mean transfusion volume with the progression from grade I to III in the APC and LC fracture types. However, more frequent pelvic fracture-associated injuries were also reported as the severity of pelvic fracture increased, likely contributing to the increased transfusion volume.

Previous studies have defined the timing of blood transfusion from 24 (12), 48 (14) to 72 h (13) after admission. In the present study, patients with pelvic fracture were transported to our Level I Trauma Centre within 2 h from the trauma with the aid of a medical rescue system. Blood transfusion was performed in the initial 6 h after pelvic fracture, based on the results of physical examination and clinical symptoms of shock.

The blood transfusion frequency and volume in the present study was similar to that in the study by Burgess et al (3). C-type pelvic fractures require a considerably larger blood transfusion volume, with almost 60% of patients requiring transfusion. However, the same result was reported for the APC III type (3,12). The considerably larger mean transfusion volume in the APC III type in Burgess' study compared with that in the present study supports this conclusion, since the C1 type in the AO classification system corresponds to the APC III type in that of Young and Burgess.

In the present study, ~50% pelvic fracture patients (types B and C) received blood transfusions of >1,500 ml. Similarly, unstable pelvic fractures, including APC II, APC III and LC III injuries, received a high blood transfusion volume (3,5,8,12,22).

In addition, patients with pelvic fractures were classified into subtypes according to the AO classification system. The blood transfusion frequency and volume were analysed in association with the subtypes. The B3 subtype of pelvic fracture had the highest transfusion frequency (53.6%), which was consistent with the results of Magnussen et al (12). Nearly 70% of patients of the C3 subtype received a blood transfusion volume of >1,500 ml. In the present analysis, the AO classification system was proven to be as effective as the system of Young and Burgess (26).

In the present study, massive blood transfusion was defined as >1,500 ml. The results indicated that C-type pelvic fractures are more likely to require massive blood transfusion. The same results were reported in other studies (12,13,22).

The ISSs of unstable pelvic fractures (types B and C) were higher than those for type A, due to the severity of pelvic disruptions and associated injuries. This result was consistent with that of Hamill et al (22).

Previous studies reported an overall mortality of 10–26% (5,13,27), while that for type C was 20% (3). The overall mortality in the present study was 1.8% and that of type C was ≤10.3%, which was inconsistent with the results of the aforementioned studies (3,5,13,27). High ISS, severe associated injuries and massive blood transfusion volume are recognized as risk factors for mortality in patients with pelvic fracture (1,4). In the present study, multiple traumas were observed in those patients that died, with the associated injuries and high blood loss volume proving to be risk factors for mortality. Of those patients, >2,000 ml blood transfusion was required for patients with C-type pelvic fractures in the initial 6 h, which required addition intensive care. The blood transfusion volume required in the initial 6 h for patients who died with types A and B were >1,000 ml and 1,500 ml, respectively. This result from the patients who died suggested an association between the blood transfusion volume and the pelvic fracture type. However, statistical analysis was not performed due to the limited numbers of types, which was another limitation of present study.

Paydar et al (1) developed a system to determine whether patients were in good or poor condition. Patients in poor condition had a lower pH, base excess and hemoglobin level, and required more packed red cell transfusion and a larger volume of infused intravenous fluid.

In the present study, all pelvic fractures were defined as closed injuries. Open pelvic fractures with combined devastating soft-tissue injuries have been reported to have relatively higher transfusion requirements and a higher mortality rate (28). Hasankhani and Omidi-Kashani (28) reported on 15 cases of open pelvic fracture associated with extensive perineal injury. The average blood transfusion volume was 8 packed red blood cell units (range, 4–21 units). A total of 2 patients with APC type III fractures were in deep shock, 1 received 21 units of blood and survived, and 1 received 18 units and died post-operatively due to an associated intra-abdominal injury. The blood transfusion and mortality rates in that study were considerably higher than those in the present one.

The optimal treatment strategy would take into consideration the hemodynamic status, disruptions of the pelvic ring and associated injuries. The aim of pelvic fracture patient management is to definitively restore hemodynamic and mechanical stability of the pelvic ring and repair associated injuries. The management of trauma must therefore be multidisciplinary and ultimately based on the physiology of the patient and the mechanism of the injury (29,30).

In the present study, a strong association was observed between blood transfusion volume and frequency in the initial 6 h and pelvic fracture type, and the subtypes with the highest transfusion frequency and largest blood transfusion volume were identified. Previous studies, which examined pelvic fracture types and attempted to assess whether the type may predict the outcome, have been limited by the time of transfusion and classification systems for pelvic fractures. In the present study, by demonstrating the marked association between pelvic fracture type and clinical outcome, including blood transfusion, it was indicated that pelvic fracture types may be used as an AO predictor of pelvic blood transfusion and help develop and validate a clinical prediction rule that relies on immediately obvious clinical factors, including fracture type and emergency department presentation, defining clinical predictors that may identify patients that are highly likely to require massive blood transfusion.

The present study had several significant limitations. First, the study was a retrospective, single-center investigation with the associated limitations. Furthermore, pelvic fracture-associated injuries, which may have led to an increase in the requirement for blood transfusion, were not entirely excluded from the study. However, separation of pelvic fractures and associated injuries may not represent the real severity of trauma and the overall amount of hemorrhage. Finally, patients with pelvic fracture may have delayed hemorrhage in the initial 6 h after pelvic fracture.

In conclusion, patients with AO fracture type A, B and C resulting from high-energy pelvic impact had a progressively larger mean transfusion volume, transfusion frequency and mortality in the initial 6 h after pelvic fracture. The B3 subtype was indicated to have the highest frequency of blood transfusion and the C3 subtype required the largest blood transfusion volume. The AO classification system is an effective and validated protocol for investigations on pelvic fracture.

 Acknowledgements

Not applicable.

 Funding

No funding was received.

 Availability of data and materials

All the data and materials are available from the corresponding author on reasonable request, as applicable.

 Authors' contributions

QY, KJ and XT were responsible for case collection; TW was responsible for statistical analysis; LA and DG were responsible for calculating volumes of blood transfusion; YF, NC and FP were responsible for analysis of clinical information.

 Ethics approval and consent to participate

This study was approved by the ethics committee of Qingpu Branch, Zhongshan Hospital affiliated to Fudan University (approval no. 201914; Shanghai, China).

 Patient consent for publication

Not applicable.

 Competing interests

The authors declare that they have no competing interests.

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Transfusion requirement by AO type. The AO type of pelvic fractures is displayed on the X-axis, whilst the Y-axis indicates the volume of blood transfusion in ml. Each column represents the amount of blood transfusion required with each different AO type of pelvic fractures. It shows a larger mean blood transfusion volume in C type pelvic fractures, as compared to the other types (χ2=46.6789, F=2, P<0.01). AO, Arbeit fuer Osteosynthese.

Transfusion requirement by AO subtype of pelvic fractures. The AO subtype of pelvic fractures is displayed on the X-axis, while the Y-axis indicates the volume of blood transfusion. Each column represents the amount of blood transfusion required with each different AO type of pelvic fractures. It was indicated that the B3 subtype had the highest transfusion frequency, while the C3 subtype had the largest volume of blood transfusion. AO, Arbeit fuer Osteosynthese.

General characteristics of the patients (n=497).

Characteristic Value
Age (years) 32±16.5
Gender
  Male 276 (55.5)
  Female 221 (44.5)
Mean ISS 16±9.08
Cause of injury
  Motor vehicle collision 306 (61.6)
  Fall from height 129 (26.0)
  Crush injury 35 (7.0)
  Fall on the ground 22 (4.4)
  Other   5 (1.0)
AO classification
  A 395 (79.5)
    A1 16 (3.2)
    A2 216 (43.5)
    A3 163 (32.8)
  B   63 (12.7)
    B1 18 (3.6)
    B2 39 (7.9)
    B3   6 (1.2)
  C 39 (7.9)
    C1 26 (5.2)
    C2 10 (2.0)
    C3   3 (0.6)
FAST +
  B   23 (36.5)
  C   20 (51.3)
Systolic blood pressure <90 mmHg 31 (6.2)
Heart frequency >130 beats per minute 44 (8.9)
Number of blood transfusion 104 (20.9)
Mean volume of blood transfusion (ml) 1213.94±1354.11

Values are expressed as the mean ± standard deviation or n (%). AO, Arbeit fuer Osteosynthese; ISS, injury severity score; FAST, Focused Assessment with Sonography for Trauma.

Blood transfusion and transfusion volume compared among different AO types.

AO type Patients (n) Transfusion Volume (ml)
A 395 49 (12.4) 437.76±282.02
B 63 32 (50.1) 1,603.13±1,203.28
C 39 323 (59.0) 2,191.30±1,740.93a
Total 497 104 (20.9)

P<0.01, χ2=46.6789 and F=2 vs. type A and B. Values are expressed as the mean ± standard deviation or n (%). AO, Arbeit fuer Osteosynthese.

Distribution of blood transfusion (n).

Volume of blood transfusion (ml)
AO type <600 600–1,500 >1,500b Total
A 42 (79.3)   7 (30.4) 0 (0) 49
B   7 (15.1) 10 (39.1) 15 (53.6) 32
C 2 (5.7)   6 (30.4) 15 (46.4) 23a
Total 51 23 30 104

P<0.01, F=4, χ2=56.9067 vs. fracture A and B

P<0.0001, F=2, χ2=39.7562 vs. fracture A and B. Values are expressed as n (%). AO, Arbeit fuer Osteosynthese.

Blood transfusion and transfusion volume compared among AO subtypes.

AO subtype Patients (n) Blood transfusion Volume (ml)
A1 16 0 (0) 0
A2 216 39 (18.1) 407.69±255.09
A3 163 10 (6.1) 540.00±368.78
B1 18 7 (38.9) 2357.14±1183.37
B2 39 20 (51.3) 1372.50±1206.18
B3 6 5 (83.3) 1470.00±962.81
C1 26 16 (61.5) 1743.75±1000.81
C2 10 5 (50.0) 2220.00±714.67
C3 3 2 (66.7) 5700.00±4666.90
Total 497 104 (20.9)

Values are expressed as the mean ± standard deviation or n (%). AO, Arbeit fuer Osteosynthese.

ISS of different AO types.

AO type Patients (n) ISS
A 395 8.93±6.38
B 63 17.95±9.21
C 39 19.46±6.12a

P<0.01, χ2=106.8412, F=2 vs. fracture A and B. Values are expressed as the mean ± standard deviation. AO, Arbeit fuer Osteosynthese; ISS, injury severity score.

Hospital stay and ICU days.

AO type Total patients Patients in hospital [n, (%)] Hospital stay (days) Patients in ICU [n, (%)] ICU stay (days)
A 395 69 (17.5) 10±2.0 0 0
B 63 42 (66.7) 14±4.1 24 (38.1) 7±5.2
C 39 39 (100) 24±3.8a 35 (89.7) 16±4.7a
Total 497 150 (30.2) 18±6.5 59 (11.9) 9±7.3

P<0.01 vs. fracture A and B. Values are expressed as the mean ± standard deviation or n (%). AO, Arbeit Fuer Osteosynthese; ICU, intensive care unit.

Mortality and morbidity.

AO type Mortality Morbidity Volume of blood transfusion (ml)
A 1 (0.3) 395 (30.5a) 1,200
B 4 (6.3) 63 (4.8) 1,686
C 4b (10.3) 39 (3.0) 2,100

P<0.01, F=2, χ2=28.3328, vs. fracture B and C.

P<0.0001 vs. fracture A and B. Values are expressed as the mean ± standard deviation or n (%). AO, Arbeit fuer Osteosynthese.