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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">IJMM</journal-id>
<journal-title-group>
<journal-title>International Journal of Molecular Medicine</journal-title></journal-title-group>
<issn pub-type="ppub">1107-3756</issn>
<issn pub-type="epub">1791-244X</issn>
<publisher>
<publisher-name>D.A. Spandidos</publisher-name></publisher></journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3892/ijmm.2024.5462</article-id>
<article-id pub-id-type="publisher-id">ijmm-55-02-05462</article-id>
<article-categories>
<subj-group>
<subject>Corrigendum</subject></subj-group></article-categories>
<title-group>
<article-title>[Corrigendum] Spicatoside A in red <italic>Liriope platyphylla</italic> displays a laxative effect in a constipation rat model via regulating mAChRs and ER stress signaling</article-title></title-group>
<contrib-group>
<contrib contrib-type="author">
<name><surname>Kim</surname><given-names>Ji Eun</given-names></name></contrib>
<contrib contrib-type="author">
<name><surname>Go</surname><given-names>Jun</given-names></name></contrib>
<contrib contrib-type="author">
<name><surname>Lee</surname><given-names>Hee Seob</given-names></name></contrib>
<contrib contrib-type="author">
<name><surname>Hong</surname><given-names>Jin Tae</given-names></name></contrib>
<contrib contrib-type="author">
<name><surname>Hwang</surname><given-names>Dae Youn</given-names></name></contrib></contrib-group>
<pub-date pub-type="collection">
<month>02</month>
<year>2025</year></pub-date>
<pub-date pub-type="epub">
<day>25</day>
<month>11</month>
<year>2024</year></pub-date>
<volume>55</volume>
<issue>2</issue>
<elocation-id>21</elocation-id>
<permissions>
<copyright-statement>Copyright: &#x000A9; 2024 Kim et al.</copyright-statement>
<copyright-year>2024</copyright-year>
<license license-type="open-access">
<license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.</license-p></license></permissions></article-meta></front>
<body>
<p>Int J Mol Med 43: <related-article id="RA1" related-article-type="corrected-article" vol="43" page="185" ext-link-type="doi" xlink:href="10.3892/ijmm.2018.3960">185-198</related-article>, 2019; DOI: 10.3892/ijmm.2018.3960</p>
<p>Following the publication of the above article, an interested reader drew to the Editor's attention that various of the histological structural images shown in <xref rid="f5-ijmm-55-02-05462" ref-type="fig">Fig. 5</xref> on p. 190 were strikingly similar to data that were featured in Fig. 1A of a previous paper by the same research group that appeared in the Journal <italic>Laboratory Animal Research</italic>. On re-examining their original data, the authors confirmed that an error occurred during the paper submission/production process, and that <xref rid="f5-ijmm-55-02-05462" ref-type="fig">Fig. 5</xref> did not appear in the above article as the authors had intended.</p>
<p>The correct version of <xref rid="f5-ijmm-55-02-05462" ref-type="fig">Fig. 5</xref>, containing the data that the authors intended for inclusion in this article, is shown on the next page. Also shown is a corrected version of <xref rid="tII-ijmm-55-02-05462" ref-type="table">Table II</xref> corresponding to the replacement version of <xref rid="f5-ijmm-55-02-05462" ref-type="fig">Fig. 5</xref>, containing data that are derived from an analysis of the data shown in this figure. Furthermore, the replacement of the images in <xref rid="f5-ijmm-55-02-05462" ref-type="fig">Fig. 5</xref>, and the revisions of the data made in <xref rid="tII-ijmm-55-02-05462" ref-type="table">Table II</xref>, also dictate that the following changes are needed to be made in the main text of the paper (all associated with Results section on p. 191, '<italic>Recovery effect of EtRLP on histological alterations of the transverse colon</italic>' subsection): The sentences in lines 9-14 of this section should now read as following (changes from the original text are highlighted in <bold>bold</bold>): 'Following Lop+EtRLP or Lop+Bisac treatments, the villus length increased by <bold>270-290%</bold> relative to the Lop+Vehicle-treated group (<xref rid="f5-ijmm-55-02-05462" ref-type="fig">Fig. 5</xref> and <xref rid="tII-ijmm-55-02-05462" ref-type="table">Table II</xref>). Furthermore, the alterations in <bold>muscle thickness</bold> were similar to those in villus length, although crypt layer thickness only increased by <bold>145-150%</bold> relative to the <bold>Lop+Vehicle-treated group</bold> (<xref rid="f5-ijmm-55-02-05462" ref-type="fig">Fig. 5</xref> and <xref rid="tII-ijmm-55-02-05462" ref-type="table">Table II</xref>)'.</p>
<p>Note that the errors made during the assembly of <xref rid="f5-ijmm-55-02-05462" ref-type="fig">Fig. 5</xref> and <xref rid="tII-ijmm-55-02-05462" ref-type="table">Table II</xref> did not grossly affect the overall conclusions reported in the paper. All the authors agree with the publication of this corrigendum, and are grateful to the Editor of <italic>International Journal of Molecular Medicine</italic> for allowing them the opportunity to publish this. They also apologize to the readership for any inconvenience caused.</p></body>
<floats-group>
<fig id="f5-ijmm-55-02-05462" position="float">
<label>Figure 5</label>
<caption>
<p>Histological structure of transverse colon collected from Lop-induced constipated rats. Following the collection of transverse colons from the Non-, EtRLP-, Lop+Vehicle-, Lop+EtRLP- and Lop+BisaC-treated groups, H&amp;E stained sections of these tissues were observed at two magnifications via light microscopy (left and middle column). Mucin on the tissue sections was stained with alcian blue (right column). Crypt layer thickness, muscle thickness, and villus length in transverse colon were measured in H&amp;E stained images with the Leica Application Suite software. EtRLP, Red Liriope platyphylla extract; Lop, loperamide; BisaC, bisacodyl; H&amp;E, hematoxylin and eosin.</p></caption>
<graphic xlink:href="ijmm-55-02-05462-g00.tif"/></fig>
<table-wrap id="tII-ijmm-55-02-05462" position="float">
<label>Table II</label>
<caption>
<p>Histological parameters of experimental rats with Lop-induced constipation.</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th rowspan="2" valign="bottom" align="left">Categories</th>
<th rowspan="2" valign="bottom" align="center">Non-treated E</th>
<th rowspan="2" valign="bottom" align="center">tRLP</th>
<th colspan="3" valign="bottom" align="center">Loperamide
<hr/></th></tr>
<tr>
<th valign="bottom" align="center">Vehicle</th>
<th valign="bottom" align="center">EtRLP</th>
<th valign="bottom" align="center">BisaC</th></tr></thead>
<tbody>
<tr>
<td valign="top" align="left">Villus length (<italic>&#x003BC;</italic>m)</td>
<td valign="top" align="center">287.9&#x000B1;14.0</td>
<td valign="top" align="center">228.7&#x000B1;20.1</td>
<td valign="top" align="center">79.5&#x000B1;14.1<xref rid="tfn1-ijmm-55-02-05462" ref-type="table-fn">a</xref></td>
<td valign="top" align="center">225.5&#x000B1;14.6<xref rid="tfn2-ijmm-55-02-05462" ref-type="table-fn">b</xref></td>
<td valign="top" align="center">217.0&#x000B1;15.0<xref rid="tfn2-ijmm-55-02-05462" ref-type="table-fn">b</xref></td></tr>
<tr>
<td valign="top" align="left">Muscle thickness (<italic>&#x003BC;</italic>m)</td>
<td valign="top" align="center">70.6&#x000B1;4.0</td>
<td valign="top" align="center">63.0&#x000B1;4.3</td>
<td valign="top" align="center">22.4&#x000B1;1.5<xref rid="tfn1-ijmm-55-02-05462" ref-type="table-fn">a</xref></td>
<td valign="top" align="center">55.2&#x000B1;3.6<xref rid="tfn2-ijmm-55-02-05462" ref-type="table-fn">b</xref></td>
<td valign="top" align="center">55.4&#x000B1;4.9<xref rid="tfn2-ijmm-55-02-05462" ref-type="table-fn">b</xref></td></tr>
<tr>
<td valign="top" align="left">Crypt layer thickness (<italic>&#x003BC;</italic>m)</td>
<td valign="top" align="center">111.1&#x000B1;37.0</td>
<td valign="top" align="center">101.5&#x000B1;26.1</td>
<td valign="top" align="center">51.2&#x000B1;2.2<xref rid="tfn1-ijmm-55-02-05462" ref-type="table-fn">a</xref></td>
<td valign="top" align="center">76.6&#x000B1;14.7<xref rid="tfn2-ijmm-55-02-05462" ref-type="table-fn">b</xref></td>
<td valign="top" align="center">75.3&#x000B1;16.2<xref rid="tfn2-ijmm-55-02-05462" ref-type="table-fn">b</xref></td></tr>
<tr>
<td valign="top" align="left">Number of goblet cell (ea)</td>
<td valign="top" align="center">315.4&#x000B1;16.3</td>
<td valign="top" align="center">316.4&#x000B1;18.7</td>
<td valign="top" align="center">161.3&#x000B1;8.1<xref rid="tfn1-ijmm-55-02-05462" ref-type="table-fn">a</xref></td>
<td valign="top" align="center">256.0&#x000B1;17.7<xref rid="tfn2-ijmm-55-02-05462" ref-type="table-fn">b</xref></td>
<td valign="top" align="center">256.8&#x000B1;20.6<xref rid="tfn2-ijmm-55-02-05462" ref-type="table-fn">b</xref></td></tr>
<tr>
<td valign="top" align="left">Number of crypt of lieberkuhn (ea)</td>
<td valign="top" align="center">30.2&#x000B1;3.3</td>
<td valign="top" align="center">25.8&#x000B1;3.3</td>
<td valign="top" align="center">11.8&#x000B1;3.5<xref rid="tfn1-ijmm-55-02-05462" ref-type="table-fn">a</xref></td>
<td valign="top" align="center">19.8&#x000B1;2.9<xref rid="tfn2-ijmm-55-02-05462" ref-type="table-fn">b</xref></td>
<td valign="top" align="center">19.6&#x000B1;3.8<xref rid="tfn2-ijmm-55-02-05462" ref-type="table-fn">b</xref></td></tr></tbody></table>
<table-wrap-foot><fn id="tfn1-ijmm-55-02-05462">
<label>a</label>
<p>P&lt;0.05 compared with the non-treated group;</p></fn><fn id="tfn2-ijmm-55-02-05462">
<label>b</label>
<p>P&lt;0.05 compared with the Lop+Vehicle-treated group. Lop, loperamide; EtRLP, Red <italic>Liriope platyphylla</italic> extract; BisaC, bisacodyl.</p></fn></table-wrap-foot></table-wrap></floats-group></article>
