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<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">OL</journal-id>
<journal-title-group>
<journal-title>Oncology Letters</journal-title>
</journal-title-group>
<issn pub-type="ppub">1792-1074</issn>
<issn pub-type="epub">1792-1082</issn>
<publisher>
<publisher-name>D.A. Spandidos</publisher-name>
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</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3892/ol.2026.15536</article-id>
<article-id pub-id-type="publisher-id">OL-31-5-15536</article-id>
<article-categories>
<subj-group>
<subject>Expression of Concern</subject>
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</article-categories>
<title-group>
<article-title>[Expression of Concern] Effect of overexpression of HOX genes on its invasive tendency in cerebral glioma</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author"><name><surname>Guo</surname><given-names>Yun-Bao</given-names></name>
</contrib>
<contrib contrib-type="author"><name><surname>Shao</surname><given-names>Yi-Meng</given-names></name>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname><given-names>Jing</given-names></name>
</contrib>
<contrib contrib-type="author"><name><surname>Xu</surname><given-names>Song-Bai</given-names></name>
</contrib>
<contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Xing-Dong</given-names></name>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname><given-names>Mao-Ren</given-names></name>
</contrib>
<contrib contrib-type="author"><name><surname>Liu</surname><given-names>Hai-Yan</given-names></name>
</contrib>
</contrib-group>
<pub-date pub-type="collection"><month>05</month><year>2026</year></pub-date>
<pub-date pub-type="epub"><day>18</day><month>03</month><year>2026</year></pub-date>
<volume>31</volume>
<issue>5</issue>
<elocation-id>181</elocation-id>
<permissions>
<copyright-statement>Copyright: &#x00A9; 2026 Guo et al.</copyright-statement>
<copyright-year>2026</copyright-year>
<license license-type="open-access">
<license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.</license-p></license>
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<body>
<p>Oncol Lett 11: <related-article xmlns:xlink="http://www.w3.org/1999/xlink" related-article-type="object-of-concern" vol="11" page="75" id="RA1" xlink:href="10.3892/ol.2015.3893" ext-link-type="doi">75&#x2013;80</related-article>, 2026; DOI: 10.3892/ol.2015.3893</p>
<p>Following the publication of the above paper, it has been drawn to the Editor&#x0027;s attention by a concerned reader that, regarding the RT-polymerase chain reaction analyses shown in Fig. 3, the data shown for the <italic>A9</italic> and <italic>D10 HOX</italic> genes were strikingly similar; in addition, the data shown for the <italic>B13</italic> and <italic>D13 HOX</italic> genes were also remarkably similar. Furthermore, the blot for the <italic>A9</italic>/<italic>D10 HOX</italic> genes for the U-118 lane also looked very similar to the blot portrayed for the <italic>D13 HOX</italic> gene in both the U-138 and U-118 lanes, and the data shown for the <italic>A6, A7, D4</italic> and <italic>D9 HOX</italic> genes all bore a strikingly close similarity. Finally, it should be noted that a cursory inspection of the data shown for the RT-polymerase chain reaction analyses in Fig. 2 revealed similar potential anomalies with respect to strikingly similar looking data used to portray various of the <italic>HOX</italic> genes.</p>
<p>The authors have been contacted by the Editorial Office to offer an explanation for these apparent anomalies in the presentation of the data in this paper, and we are awaiting their response. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of these potential problems while the Editorial Office continues to investigate this matter further.</p>
</body>
</article>
