Open Access

Gender difference and genetic variance in lipoprotein receptor‑related protein 1 is associated with mortality

  • Authors:
    • Urban Alehagen
    • Dick Wågsäter
  • View Affiliations

  • Published online on: May 24, 2019     https://doi.org/10.3892/br.2019.1217
  • Pages: 3-10
  • Copyright: © Alehagen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cardiovascular diseases are an important health resource problem and studies have shown a genetic association between single nucleotide polymorphisms (SNPs) and cardiovascular diseases. According to the literature, lipoprotein receptor‑related protein 1 (LRP1) is associated with coronary artery disease. The aim of the present study was to evaluate a possible association between different genotypes of LRP1 and all‑cause and cardiovascular mortality from a gender perspective. In the present study, 489 elderly community‑living people were invited to participate. Clinical examination, echocardiography and blood sampling including SNP analyses of LRP1 (rs1466535) were performed, including the T/T, C/T and C/C genotypes, and the participants were followed for 6.7 years. During the follow‑up period, 116 (24%) all‑cause and 75 (15%) cardiovascular deaths were registered. In the female population, the LRP1 of the T/T or C/T genotype exhibited a 5.6‑fold increased risk of cardiovascular mortality and a 2.8‑fold increased risk of all‑cause mortality compared with the C/C genotype. No such genotype differences could be seen in the male population. Gender differences could be seen regarding the risk of mortality in the different genotypes. Females with the LRP1 T/T or C/T genotypes exhibited a significantly increased risk of both all‑cause and cardiovascular mortality compared with the C/C genotypes. Therefore, more individualized cardiovascular prevention and treatment should be prioritized. However, since this was a small study, the observations should only be regarded as hypothesis‑generating.
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July-2019
Volume 11 Issue 1

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Spandidos Publications style
Alehagen U and Alehagen U: Gender difference and genetic variance in lipoprotein receptor‑related protein 1 is associated with mortality. Biomed Rep 11: 3-10, 2019
APA
Alehagen, U., & Alehagen, U. (2019). Gender difference and genetic variance in lipoprotein receptor‑related protein 1 is associated with mortality. Biomedical Reports, 11, 3-10. https://doi.org/10.3892/br.2019.1217
MLA
Alehagen, U., Wågsäter, D."Gender difference and genetic variance in lipoprotein receptor‑related protein 1 is associated with mortality". Biomedical Reports 11.1 (2019): 3-10.
Chicago
Alehagen, U., Wågsäter, D."Gender difference and genetic variance in lipoprotein receptor‑related protein 1 is associated with mortality". Biomedical Reports 11, no. 1 (2019): 3-10. https://doi.org/10.3892/br.2019.1217