Open Access

Glycolysis-associated enzymes existing in the follicular lumen of the thyroid may interfere with energy metabolism

  • Authors:
    • Huibin Huang
    • Yaxiong Shi
    • Huiyao Cai
    • Bo Liang
    • Honghong Duan
    • Qingyan Cai
  • View Affiliations

  • Published online on: July 18, 2016     https://doi.org/10.3892/br.2016.721
  • Pages: 317-320
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Synthesis and storage of the thyroid hormone precursor, thyroglobulin (TG), occurs within the follicular lumen of the thyroid and the TG is then absorbed into cells for further processing before release into the blood. However, the mechanism of energy metabolism in the follicular lumen of the thyroid remains unknown. In the present study, the three dimensional structure of thyroid follicles was constructed using a primary culture of swine cells and the follicular protein was identified via matrix-assisted laser desorption/ionization-time of flight mass spectrometry. Three glycolysis-associated enzymes, enolase, pyruvate kinase and phosphoglyceraldehyde dehydrogenase were identified in addition to TG. These results support the hypothesis that anaerobic glycolysis of glucose exists in the follicle and supports energy consumption for hormone synthesis.
View Figures
View References

Related Articles

Journal Cover

September-2016
Volume 5 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Huang H, Shi Y, Cai H, Liang B, Duan H and Cai Q: Glycolysis-associated enzymes existing in the follicular lumen of the thyroid may interfere with energy metabolism. Biomed Rep 5: 317-320, 2016
APA
Huang, H., Shi, Y., Cai, H., Liang, B., Duan, H., & Cai, Q. (2016). Glycolysis-associated enzymes existing in the follicular lumen of the thyroid may interfere with energy metabolism. Biomedical Reports, 5, 317-320. https://doi.org/10.3892/br.2016.721
MLA
Huang, H., Shi, Y., Cai, H., Liang, B., Duan, H., Cai, Q."Glycolysis-associated enzymes existing in the follicular lumen of the thyroid may interfere with energy metabolism". Biomedical Reports 5.3 (2016): 317-320.
Chicago
Huang, H., Shi, Y., Cai, H., Liang, B., Duan, H., Cai, Q."Glycolysis-associated enzymes existing in the follicular lumen of the thyroid may interfere with energy metabolism". Biomedical Reports 5, no. 3 (2016): 317-320. https://doi.org/10.3892/br.2016.721