Long-term supplementation with young coconut juice does not prevent bone loss but rather alleviates body weight gain in ovariectomized rats

  • Authors:
    • Hiroshi Matsushita
    • Akira Minami
    • Hiroaki Kanazawa
    • Takashi Suzuki
    • Sanan Subhadhirasakul
    • Kazushi Watanabe
    • Akihiko Wakatsuki
  • View Affiliations

  • Published online on: April 5, 2017     https://doi.org/10.3892/br.2017.883
  • Pages: 585-591
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Abstract

Young coconut (Cocos nucifera Linn.) juice (YCJ) has traditionally been consumed to alleviate symptoms associated with the menopause. Recently, the authors demonstrated that short‑term (6‑week) YCJ supplementation to ovariectomized rats resulted in increased bone mass and bone formation parameter, suggesting that YCJ consumption has a positive effect on bone metabolism and may represent an intervention to help slow the bone loss during menopause transition. The present study sought to determine how long‑term (12‑week) YCJ supplementation affects bone metabolism in ovariectomized rats, to investigate whether such supplementation may be helpful to in osteoporosis treatment. Ten‑week‑old female Wistar rats were subjected to either a sham operation (Sham) or bilateral ovariectomy (Ovx). The Ovx+YCJ group received 5X‑concentrated YCJ at a dose of 15 ml/kg/day for 12 weeks. Rats in the Ovx group had significantly lower femur bone mineral density than those in the Sham group. YCJ supplementation did not significantly affect this difference. However, YCJ prevented the increase in bone area of the mid third of the femur, a site high in cortical bone, and body weight gain observed following Ovx. Our findings indicate that long‑term YCJ intake does not alter bone loss, but rather alleviates body weight gain following menopause.
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May-2017
Volume 6 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Matsushita H, Minami A, Kanazawa H, Suzuki T, Subhadhirasakul S, Watanabe K and Wakatsuki A: Long-term supplementation with young coconut juice does not prevent bone loss but rather alleviates body weight gain in ovariectomized rats. Biomed Rep 6: 585-591, 2017
APA
Matsushita, H., Minami, A., Kanazawa, H., Suzuki, T., Subhadhirasakul, S., Watanabe, K., & Wakatsuki, A. (2017). Long-term supplementation with young coconut juice does not prevent bone loss but rather alleviates body weight gain in ovariectomized rats. Biomedical Reports, 6, 585-591. https://doi.org/10.3892/br.2017.883
MLA
Matsushita, H., Minami, A., Kanazawa, H., Suzuki, T., Subhadhirasakul, S., Watanabe, K., Wakatsuki, A."Long-term supplementation with young coconut juice does not prevent bone loss but rather alleviates body weight gain in ovariectomized rats". Biomedical Reports 6.5 (2017): 585-591.
Chicago
Matsushita, H., Minami, A., Kanazawa, H., Suzuki, T., Subhadhirasakul, S., Watanabe, K., Wakatsuki, A."Long-term supplementation with young coconut juice does not prevent bone loss but rather alleviates body weight gain in ovariectomized rats". Biomedical Reports 6, no. 5 (2017): 585-591. https://doi.org/10.3892/br.2017.883