Open Access

Protective effect of Pu-erh tea extracts against ethanol-induced gastric mucosal damage in rats

  • Authors:
    • Jinna Yang
    • Wangyi Zhou
    • Yaru Gu
    • Jinwei Dai
    • Xinxin Li
    • Ping Tai
    • Yanchuan Li
    • Xiaohui Ma
    • Yuyang Zhang
  • View Affiliations

  • Published online on: February 20, 2018     https://doi.org/10.3892/br.2018.1068
  • Pages: 335-342
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pu-erh tea has become a focus of research due to its reported biological activities, including anti-oxidation, anti-inflammation and anti-immunosenescence. The present study was performed to evaluate the potential gastroprotective function of Pu-erh tea extracts against ethanol‑induced gastric mucosal damage in rats. Sprague Dawley rats were randomly divided into seven groups: A normal control, a model control, a cimetidine (0.08 g/kg) group, three Pu‑erh tea extracts groups (low, moderate and high‑dose; 0.50, 1.00 and 1.50 g/kg, respectively, and a green tea powder (1.00 g/kg) group. The normal and model groups were pre‑treated with distilled water while the other groups were respectively administered cimetidine, Pu‑erh tea extracts and green tea powder for 14 days. Then, absolute ethanol was orally administered to the rats of all groups excluding the normal controls. The effects of the pretreatments on gastric mucosal injury were evaluated by gross assessment of gastric lesions, examination of histopathology and determination of myeloperoxidase (MPO) activity and asymmetric arginine (ADMA) concentration in gastric mucosal homogenate. Pre‑treatment with cimetidine or Pu‑erh tea extracts markedly suppressed the formation of ethanol‑induced gastric lesions. Furthermore, clear decreases in MPO activity and ADMA concentration in the gastric mucosal homogenate were observed following pretreatment with cimetidine or Pu‑erh tea extracts. The anti‑gastric ulcer activity of green tea was less than that of Pu‑erh tea. Overall, these effects of Pu‑erh tea extracts may be due to potential functions in protecting the gastric mucus layer and suppressing inflammation.
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April-2018
Volume 8 Issue 4

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Spandidos Publications style
Yang J, Zhou W, Gu Y, Dai J, Li X, Tai P, Li Y, Ma X and Zhang Y: Protective effect of Pu-erh tea extracts against ethanol-induced gastric mucosal damage in rats. Biomed Rep 8: 335-342, 2018
APA
Yang, J., Zhou, W., Gu, Y., Dai, J., Li, X., Tai, P. ... Zhang, Y. (2018). Protective effect of Pu-erh tea extracts against ethanol-induced gastric mucosal damage in rats. Biomedical Reports, 8, 335-342. https://doi.org/10.3892/br.2018.1068
MLA
Yang, J., Zhou, W., Gu, Y., Dai, J., Li, X., Tai, P., Li, Y., Ma, X., Zhang, Y."Protective effect of Pu-erh tea extracts against ethanol-induced gastric mucosal damage in rats". Biomedical Reports 8.4 (2018): 335-342.
Chicago
Yang, J., Zhou, W., Gu, Y., Dai, J., Li, X., Tai, P., Li, Y., Ma, X., Zhang, Y."Protective effect of Pu-erh tea extracts against ethanol-induced gastric mucosal damage in rats". Biomedical Reports 8, no. 4 (2018): 335-342. https://doi.org/10.3892/br.2018.1068