Serum homocysteine is associated with polycystic ovarian syndrome in Jordan

  • Authors:
    • Nesreen Saadeh
    • Mahmoud A. Alfaqih
    • Haneen Mansour
    • Yousef S. Khader
    • Rami Saadeh
    • Ahmed Al‑Dwairi
    • Mohamad Nusier
  • View Affiliations

  • Published online on: September 13, 2018     https://doi.org/10.3892/br.2018.1149
  • Pages: 439-445
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Abstract

Polycystic ovarian syndrome (PCOS) is a prevalent endocrinopathy among women of a reproductive age. Although not included in the diagnostic criteria, insulin resistance (IR) is a major characteristic of PCOS and may contribute to its development. The exact cause of IR remains unknown but appears to be multifactorial. Changes in the levels of leptin, adiponectin, branched‑chain amino acids (BCAAs) and/or homocysteine have been reported in women with PCOS. However, the relative contribution of the aforementioned metabolites to PCOS has not been tested in Jordan. In the present study, 154 women diagnosed with PCOS and 151 normally menstruating women matched by age and body mass index (BMI) were recruited. The levels of leptin, adiponectin, BCAAs, homocysteine and 5‑methyltetrahydrofolate (5‑MTHF) were measured in the serum of the recruited participants. It was revealed that homocysteine levels were significantly elevated in women with PCOS compared with normally menstruating women (P<0.0001), while 5‑MTHF (P=0.024), leptin (P=0.027) and adiponectin (P=0.010) levels were significantly lower. In multivariate analysis, serum homocysteine had the strongest association with PCOS and significantly increased its risk [P<0.0001; odds ratio 1.217; 95% confidence interval (CI) 1.157‑1.280]. With an area under the curve of 0.855 (95% CI 0.811‑0.898) in receiver operating characteristic analysis, serum homocysteine was determined to be a good predictor for PCOS diagnosis based on Rotterdam guidelines. It was concluded that serum levels of homocysteine are elevated in women with PCOS in Jordan independent of age, BMI, or leptin, adiponectin and BCAAs levels.
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November-2018
Volume 9 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Saadeh N, Alfaqih MA, Mansour H, Khader YS, Saadeh R, Al‑Dwairi A and Nusier M: Serum homocysteine is associated with polycystic ovarian syndrome in Jordan. Biomed Rep 9: 439-445, 2018
APA
Saadeh, N., Alfaqih, M.A., Mansour, H., Khader, Y.S., Saadeh, R., Al‑Dwairi, A., & Nusier, M. (2018). Serum homocysteine is associated with polycystic ovarian syndrome in Jordan. Biomedical Reports, 9, 439-445. https://doi.org/10.3892/br.2018.1149
MLA
Saadeh, N., Alfaqih, M. A., Mansour, H., Khader, Y. S., Saadeh, R., Al‑Dwairi, A., Nusier, M."Serum homocysteine is associated with polycystic ovarian syndrome in Jordan". Biomedical Reports 9.5 (2018): 439-445.
Chicago
Saadeh, N., Alfaqih, M. A., Mansour, H., Khader, Y. S., Saadeh, R., Al‑Dwairi, A., Nusier, M."Serum homocysteine is associated with polycystic ovarian syndrome in Jordan". Biomedical Reports 9, no. 5 (2018): 439-445. https://doi.org/10.3892/br.2018.1149