1. Protective Effect of Baicalein on oxLDL-induced Oxidative Stress and Inflammation Injury in Endothelial Cell
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  2. Physiological and therapeutic regulation of PCSK9 activity in cardiovascular disease
    Simon Glerup et al, 2017, Basic Res Cardiol CrossRef
  3. Relation of circulating PCSK9 concentration to fibrinogen in patients with stable coronary artery disease
    Yan Zhang et al, 2014, Journal of Clinical Lipidology CrossRef
  4. LDL apheresis in Japan
    Hisashi Makino et al, 2017, Transfusion and Apheresis Science CrossRef
  5. The dual behavior of PCSK9 in the regulation of apoptosis is crucial in Alzheimer’s disease progression (Review)
    QI WU et al, 2014 CrossRef
  6. ABO blood group in relation to plasma lipids and proprotein convertase subtilisin/kexin type 9
    Sha Li et al, 2015, Nutrition, Metabolism and Cardiovascular Diseases CrossRef
  7. Association of plasma PCSK9 levels with white blood cell count and its subsets in patients with stable coronary artery disease
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  8. Imbalanced cholesterol metabolism in Alzheimer's disease
    Zhao Xue-shan et al, 2016, Clinica Chimica Acta CrossRef
  9. Oxidized low-density lipoprotein (oxLDL) affects load-free cell shortening of cardiomyocytes in a proprotein convertase subtilisin/kexin 9 (PCSK9)-dependent way
    Klaus-Dieter Schlüter et al, 2017, Basic Res Cardiol CrossRef
  10. The PCSK9-LDL Receptor Axis and Outcomes in Heart Failure
    Antoni Bayes-Genis et al, 2017, Journal of the American College of Cardiology CrossRef
  11. Proprotein Convertase Subtilisin/Kexin 9 Levels in Relation to Systemic Immune Activation and Subclinical Coronary Plaque in HIV
    Markella V Zanni et al, 2017 CrossRef
  12. PCSK9 signaling pathways and their potential importance in clinical practice
    Michał Wiciński et al, 2017, EPMA Journal CrossRef
  13. High circulating proprotein convertase subtilisin/Kexin type 9 concentration associates with cardiovascular risk
    Chengfeng Qiu et al, 2017, Medicine CrossRef
  14. Hypothesis
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  15. New role of PCSK9 in atherosclerotic inflammation promotion involving the TLR4/NF-κB pathway
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  16. Propofol selectively inhibits nuclear factor-κB activity by suppressing p38 mitogen-activated protein kinase signaling in human EA.hy926 endothelial cells during intermittent hypoxia/reoxygenation
    DONGLIANG LI et al, 2014 CrossRef
  17. Circulating PCSK9 levels and 2-hPG are positively correlated in metabolic diseases in a Chinese Han population.
    Wen Guo et al, 2018, Lipids Health Dis CrossRef
  18. PCSK9 induces a pro-inflammatory response in macrophages
    Chiara Ricci et al, 2018, Sci Rep CrossRef
  19. Mature proprotein convertase subtilisin/kexin type 9, coronary atheroma burden, and vessel remodeling in heterozygous familial hypercholesterolemia
    Yu Kataoka et al, 2017, Journal of Clinical Lipidology CrossRef
  20. Pleiotropic Anti-atherosclerotic Effects of PCSK9 InhibitorsFrom Molecular Biology to Clinical Translation
    Angelos D. Karagiannis et al, 2018, Curr Atheroscler Rep CrossRef
  21. PCSK9 monoclonal antibodies reverse the pro-inflammatory profile of monocytes in familial hypercholesterolaemia
    Sophie J. Bernelot Moens et al, 2017 CrossRef
  22. PCSK9: A potential regulator of apoE/apoER2 against inflammation in atherosclerosis?
    Xue-qin Bai et al, 2018, Clinica Chimica Acta CrossRef
  23. Role of PCSK9 in lipid metabolism and atherosclerosis
    Xiao-Long Lin et al, 2018, Biomedicine & Pharmacotherapy CrossRef
  24. PCSK9 in relation to coronary plaque inflammation: Results of the ATHEROREMO-IVUS study
    Jin M. Cheng et al, 2016, Atherosclerosis CrossRef
  25. PCSK9 and neurocognitive function: Should it be still an issue after FOURIER and EBBINGHAUS results?
    Massimo R. Mannarino et al, 2018, Journal of Clinical Lipidology CrossRef
  26. Naringin activates AMPK resulting in altered expression of SREBPs, PCSK9, and LDLR to reduce body weight in obese C57BL/6J mice
    GUO-GUANG SUI et al, 2018, J. Agric. Food Chem. CrossRef
  27. Plasma Levels of Proprotein Convertase Subtilisin/Kexin Type 9 Are Elevated in Patients With Peripheral Artery Disease and Associated With Metabolic Disorders and Dysfunction in Circulating Progenitor Cells
    Ting‐Hsing Chao et al, 2016, J Am Heart Assoc CrossRef
  28. PCSK9: A novel inflammation modulator in atherosclerosis?
    Zhi-Han Tang et al, 2018, J Cell Physiol CrossRef
  29. Induction of Sustained Hypercholesterolemia by Single Adeno-Associated Virus–Mediated Gene Transfer of Mutant hPCSK9
    Marta Roche-Molina et al, 2015, Arterioscler Thromb Vasc Biol. CrossRef
  30. Inhibiting PCSK9 — biology beyond LDL control
    Robert M. Stoekenbroek et al, 2018, Nat Rev Endocrinol CrossRef
  31. Design of the randomized, placebo-controlled evolocumab for early reduction of LDL-cholesterol levels in patients with acute coronary syndromes (EVOPACS) trial
    Konstantinos C. Koskinas et al, 2018, Clin Cardiol CrossRef
  32. Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology
    José Tuñón et al, 2018 CrossRef
  33. Pretreatment With PCSK9 Inhibitor Protects the Brain Against Cardiac Ischemia/Reperfusion Injury Through a Reduction of Neuronal Inflammation and Amyloid Beta Aggregation
    Nattayaporn Apaijai et al, 2019, J Am Heart Assoc CrossRef
  34. Potentiation of Psoriasis-Like Inflammation by PCSK9
    Chao Luan et al, 2018, Journal of Investigative Dermatology CrossRef
  35. Treatment of hypercholesterolaemia with PCSK9 inhibitors in patients after cardiac transplantation
    Michael Kühl et al, 2019, PLoS ONE CrossRef
  36. Dyslipidemia: Contemporary Therapy Options in Terms of Worldwide Guidelines
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  37. Sex Differences Associated With Circulating PCSK9 in Patients Presenting With Acute Myocardial Infarction
    Zhong Zhang et al, 2019, Sci Rep CrossRef
  38. Lowering serum lipids via PCSK9-targeting drugs: current advances and future perspectives
    Ni-ya He et al, 2017, Acta Pharmacol Sin CrossRef
  39. Circulating PCSK9 concentrations are increased in postmenopausal women with the metabolic syndrome
    Nutjaree Jeenduang, 2019, Clinica Chimica Acta CrossRef
  40. Identification of PCSK9 as a novel serum biomarker for the prenatal diagnosis of neural tube defects using iTRAQ quantitative proteomics
    Dong An et al, 2015, Sci Rep CrossRef
  41. Ginkgolide B Mediated Alleviation of Inflammatory Cascades and Altered Lipid Metabolism in HUVECs via Targeting PCSK-9 Expression and Functionality
    Gang Wang et al, 2019, BioMed Research International CrossRef
  42. 冠動脈疾患を有する家族性高コレステロール血症の血液中proprotein convertase subtilisin/kexin 9の意義
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  43. Familial Hypercholesterolemia and Lipoprotein Apheresis
    Hisashi Makino et al, 2019, JAT CrossRef
  44. PCSK9 and inflammation: a review of experimental and clinical evidence
    Amir Abbas Momtazi-Borojeni et al, 2019 CrossRef
  45. The Expression of Inflammatory Cytokines on the Aorta Endothelia Are Up-regulated in Pinealectomized Rats
    Yu Wang et al, 2013, Inflammation CrossRef
  46. Targeting the Proprotein Convertase Subtilisin/Kexin Type 9 for the Treatment of Dyslipidemia and Atherosclerosis
    Daniel Urban et al, 2013, Journal of the American College of Cardiology CrossRef
  47. Serum PCSK9 is modified by interleukin-6 receptor antagonism in patients with hypercholesterolaemia following non-ST-elevation myocardial infarction
    Thor Ueland et al, 2018, Open Heart CrossRef
  48. The Relationship between the Plasma PCSK9 Levels and Platelet Indices in Patients with Stable Coronary Artery Disease
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  50. PCSK9: A key factor modulating atherosclerosis
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  51. Perspektiven zu cholesterinwirksamer Behandlung 2014
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  53. Atherosclerosis: Recent trials, new targets and future directions
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  54. Proprotein convertase subtilisin/kexin type 9 (PCSK9) in lipid metabolism, atherosclerosis and ischemic stroke
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  55. Proprotein convertase subtilisin-kexin type 9 as a biomarker for the severity of coronary artery disease
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  56. Local effects of human PCSK9 on the atherosclerotic lesion
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  57. Emerging innovative therapeutic approaches targeting PCSK9 to lower lipids
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  58. Macrophage-mediated cholesterol handling in atherosclerosis.
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  59. From proprotein convertase subtilisin/kexin type 9 to its inhibition: state-of-the-art and clinical implications
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  60. Human PCSK9 promotes hepatic lipogenesis and atherosclerosis development via apoE- and LDLR-mediated mechanisms
    Hagai Tavori et al, 2016, Cardiovasc Res CrossRef
  61. Biology of proprotein convertase subtilisin kexin 9: beyond low-density lipoprotein cholesterol lowering
    Giuseppe Danilo Norata et al, 2016, Cardiovasc Res CrossRef
  62. The anti-adipogenic effect of peripheral blood mononuclear cells is absent with PCSK9 loss-of-function variants
    AnneMarie Gagnon et al, 2016, Obesity CrossRef
  63. Correlation between serum levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) and atherogenic lipoproteins in patients with coronary artery disease
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  64. Inhibitory effect of PCSK9 on Abca1 protein expression and cholesterol efflux in macrophages
    Maria Pia Adorni et al, 2017, Atherosclerosis CrossRef
  65. Macrophage Apoptosis and Necrotic Core Development in Atherosclerosis: A Rapidly Advancing Field with Clinical Relevance to Imaging and Therapy.
    Leticia Gonzalez et al, 2017, Can J Cardiol CrossRef
  66. PCSK9 Promotes oxLDL-Induced PC12 Cell Apoptosis Through the Bcl-2/Bax-Caspase 9/3 Signaling Pathway
    Lu-Shan Liu et al, 2017, JAD CrossRef
  67. Hypercholesterolemia: The role of PCSK9
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  68. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Its Inhibitors: a Review of Physiology, Biology, and Clinical Data
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  69. Circulating PCSK9 and cardiovascular events in FH patients with standard lipid-lowering therapy
    Ye-Xuan Cao et al, 2019, J Transl Med CrossRef
  70. A Review of PCSK9 Inhibitors and their Effects on Cardiovascular Diseases
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  71. Role of PCSK9 in the course of ejection fraction change after ST‐segment elevation myocardial infarction: a pilot study
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  72. Lowering inflammation through lipid-lowering therapy: are we there yet?
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  73. Are anti-inflammatory agents and nutraceuticals - novel inhibitors of PCSK9?
    Rana Shafabakhsh et al, 2020, Critical Reviews in Food Science and Nutrition CrossRef
  74. Research progress on alternative non-classical mechanisms of PCSK9 in atherosclerosis in patients with and without diabetes
    Ying Tang et al, 2020, Cardiovasc Diabetol CrossRef
  75. Naturally Occurring PCSK9 Inhibitors
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  76. PCSK9 Expression in Epicardial Adipose Tissue: Molecular Association with Local Tissue Inflammation
    Elena Dozio et al, 2020, Mediators of Inflammation CrossRef
  77. Anti-inflammatory effects of non-statin low-density lipoprotein cholesterol-lowering drugs: an unused potential?
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  78. Proprotein convertase subtilisin/kexin type 9 inhibition in cardiovascular disease: current status and future perspectives
    Kyung Hoon Cho et al, 2020, Korean J Intern Med CrossRef
  79. Physiology and role of PCSK9 in vascular disease: Potential impact of localized PCSK9 in vascular wall
    Yanan Guo et al, 2020, J Cell Physiol CrossRef
  80. PCSK9: A Potential Therapeutic Target for Sepsis
    Yuan Yuan et al, 2020, Journal of Immunology Research CrossRef
  81. PCSK9 in Myocardial Infarction and Cardioprotection: Importance of Lipid Metabolism and Inflammation
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  82. Differential Effects of DPP-4 Inhibitors, Anagliptin and Sitagliptin, on PCSK9 Levels in Patients with Type 2 Diabetes Mellitus who are Receiving Statin Therapy
    Masato Furuhashi et al, 2020, JAT CrossRef
  83. Role of Proprotein Convertase Subtilisin/Kexin Type 9 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts
    Ga Eun Lee et al, 2021, Front. Endocrinol. CrossRef
  84. HMGB1/RAGE/TLR4 axis and glutamate as novel targets for PCSK9 inhibitor in high fat cholesterol diet induced cognitive impairment and amyloidosis
    Sally A. Abuelezz et al, 2021, Life Sciences CrossRef
  85. Circulating levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) are associated with monocyte subsets in patients with stable coronary artery disease
    Konstantin A. Krychtiuk et al, 2021, Journal of Clinical Lipidology CrossRef
  86. Pleiotropic Effects of PCSK-9 Inhibitors
    Marcin Basiak et al, 2021, IJMS CrossRef
  87. PCSK9 and LRP5 in macrophage lipid internalization and inflammation.
    Lina Badimon et al, 2021, Cardiovasc Res CrossRef
  88. Antiplatelet Effects of PCSK9 Inhibitors in Primary Hypercholesterolemia
    Piotr Pęczek et al, 2021, Life CrossRef
  89. Pcsk9 Knockout Aggravated Experimental Apical Periodontitis via LDLR
    L. Huang et al, 2021, J Dent Res CrossRef
  90. Prognostic Value of PCSK9 Levels in Non-ST elevation myocardial infarction Patients Undergoing Percutaneous Coronary Intervention (PCI)
    Jixiang Wang et al, 2021, Hellenic Journal of Cardiology CrossRef
  91. Inclisiran—Silencing the Cholesterol, Speaking up the Prognosis
    Sylwester Rogula et al, 2021, JCM CrossRef
  92. Proprotein convertase subtilisin/kexin type 9 (PCSK9): A potential multifaceted player in cancer
    Anindita Bhattacharya et al, 2021, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer CrossRef
  93. Association between PCSK9 Levels and Markers of Inflammation, Oxidative Stress, and Endothelial Dysfunction in a Population of Nondialysis Chronic Kidney Disease Patients
    Evangelia Dounousi et al, 2021, Oxidative Medicine and Cellular Longevity CrossRef
  94. Role of PCSK9 in Homocysteine-Accelerated Lipid Accumulation in Macrophages and Atherosclerosis in ApoE−/− Mice
    Ping Jin et al, 2021, Front. Cardiovasc. Med. CrossRef
  95. PCSK9/LDLR System and Rheumatoid Arthritis-Related Atherosclerosis
    Aikaterini Arida et al, 2021, Front. Cardiovasc. Med. CrossRef
  96. Proprotein Convertase Subtilisin/Kexin Type 9 and Systemic Inflammatory Biomarker Pentraxin 3 for Risk Stratification Among STEMI Patients Undergoing Primary PCI
    Xiaoxiao Zhao et al, 2021, JIR CrossRef
  97. Acute-Phase Plasma PCSK9 Levels and Recurrent Cardiovascular Events in a Chinese Acute Myocardial Infarction Cohort
    Yan Gao et al, 2018, Cardiology CrossRef
  98. The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2
    Suan-Sin Foo et al, 2021, Cell Reports Medicine CrossRef
  99. Beneficial effects of PCSK9 inhibition with alirocumab in familial hypercholesterolemia involve modulation of new immune players
    Patrice Marques et al, 2022, Biomedicine & Pharmacotherapy CrossRef
  100. Rotigotine protects against oxidized low-density lipoprotein(ox-LDL)-induced damages in human umbilical vein endothelial cells(HUVECs)
    Hui Kang et al, 2021, Bioengineered CrossRef
  101. Effects of PCSK9 Targeting: Alleviating Oxidation, Inflammation, and Atherosclerosis
    Emily Punch et al, 2022, JAHA CrossRef
  102. Proprotein Convertase Subtilisin/Kexin Type 9 and Inflammation: An Updated Review
    Na-Qiong Wu et al, 2022, Front. Cardiovasc. Med. CrossRef
  103. Insight into the Evolving Role of PCSK9
    Mateusz Maligłówka et al, 2022, Metabolites CrossRef
  104. Antitumor activity and molecular mechanism of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition
    Huimin Sun et al, 2022, Naunyn-Schmiedeberg's Arch Pharmacol CrossRef
  105. Protective Mechanism of Proprotein Convertase Subtilisin-Like Kexin Type 9 Inhibitor on Rats with Middle Cerebral Artery Occlusion-Induced Cerebral Ischemic Infarction
    Shengxiong Pu et al, 2022, Computational Intelligence and Neuroscience CrossRef
  106. The R93C Variant of PCSK9 Reduces the Risk of Premature MI in a Chinese Han Population
    Lincheng Yang et al, 2022, Front. Genet. CrossRef
  107. New Treatment Targets and Innovative Lipid-Lowering Therapies in Very-High-Risk Patients with Cardiovascular Disease
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  108. Mechanisms and Drug Therapies of Bioprosthetic Heart Valve Calcification
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  109. PCSK9 and Other Metabolic Targets to Counteract Ischemia/Reperfusion Injury in Acute Myocardial Infarction and Visceral Vascular Surgery
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  110. PCSK9 Inhibition could be Effective for Acute Myocardial Infarction
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  111. Expanding Biology of PCSK9: Roles in Atherosclerosis and Beyond
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  112. Serum cholesterol loading capacity of macrophages is regulated by seropositivity and C-reactive protein in rheumatoid arthritis patients
    George A Karpouzas et al, 2022 CrossRef
  113. Relationship between PCSK9 and endothelial function in patients with acute myocardial infarction
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  114. LDL oxydées et récepteur des LDL oxydées associés à la proprotéine-convertase-subtilisine/kexine type 9 chez des patients avec diabète de type 2
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  115. Genotype‐driven NPC1L1 and PCSK9 inhibition and reduced risk of periodontitis
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  116. The relationship between pulse pressure with plasma PCSK9 and interleukin-6 among patients with acute ischemic stroke and dyslipidemia
    Chen-Shu Chang et al, 2022, Brain Research CrossRef
  117. The circulating furin-cleaved/mature PCSK9 ratio has a potential prognostic significance in statin-naïve patients with acute ST elevation myocardial infarction
    Jun Sawaguchi et al, 2022, Atherosclerosis Plus CrossRef
  118. Evolocumab for prevention of microvascular dysfunction in patients undergoing percutaneous coronary intervention: the randomised, open-label EVOCATION trial
    Masaharu Ishihara et al, 2022 CrossRef
  119. PCSK9 Confers Inflammatory Properties to Extracellular Vesicles Released by Vascular Smooth Muscle Cells
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  120. Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms
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  121. Pharmaco-invasive therapy: Early implementation of statins and proprotein convertase subtilisin/kexin type 9 inhibitors after acute coronary syndrome
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  122. PCSK9 in Liver Cancers at the Crossroads between Lipid Metabolism and Immunity
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  124. PCSK9 Inhibitors Have Apolipoprotein C-III-Related Anti-Inflammatory Activity, Assessed by 1H-NMR Glycoprotein Profile in Subjects at High or very High Cardiovascular Risk
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