1. Icariin Stimulates Differentiation and Suppresses Adipocytic Transdifferentiation of Primary Osteoblasts Through Estrogen Receptor-Mediated Pathway.
    Dawei Zhang et al, 2016, Calcif Tissue Int CrossRef
  2. Slowly Delivered Icariin/Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells to Promote the Healing of Calvarial Critical-Size Bone Defects
    Tianlin Liu et al, 2016, Stem Cells International CrossRef
  3. Icariin promotes directed chondrogenic differentiation of bone marrow mesenchymal stem cells but not hypertrophy in vitro
    ZHI CONG WANG et al, 2014 CrossRef
  4. Regulation of the levels of Smad1 and Smad5 in MC3T3-E1 cells by Icariine in vitro
    HUIFANG ZHOU et al, 2014 CrossRef
  5. Shikonin stimulates MC3T3-E1 cell proliferation and differentiation via the BMP-2/Smad5 signal transduction pathway
    Tao Fang et al, 2016 CrossRef
  6. Effect of serum from postmenopausal women with osteoporosis exhibiting the Kidney-Yang deficiency pattern on bone formation in an hFOB 1.19 human osteoblastic cell line
    YACHAN LI et al, 2015 CrossRef
  7. Tongue coating microbiome regulates the changes in tongue texture and coating in patients with post-menopausal osteoporosis of Gan-shen deficiency syndrome type
    WENNA LIANG et al, 2013 CrossRef
  8. Hedgehog signaling is involved in the BMP9-induced osteogenic differentiation of mesenchymal stem cells
    LI LI et al, 2015 CrossRef
  9. Effect of icariin on fracture healing in an ovariectomized rat model of osteoporosis
    Hong Cao et al, 2017 CrossRef
  10. Role of miR-146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro.
    Lei Jin et al, 2014, Int. J. Mol. Med. CrossRef
  11. Effects of flavonoids incorporated biological macromolecules based scaffolds in bone tissue engineering
    S. Preethi Soundarya et al, 2017, International Journal of Biological Macromolecules CrossRef
  12. The effect of icariin on bone metabolism and its potential clinical application.
    Z Wang et al, 2018, Osteoporos Int CrossRef
  13. Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism
    Jing Lin et al, 2017, BST CrossRef
  14. Costunolide increases osteoblast differentiation via ATF4-dependent HO-1 expression in C3H10T1/2 cells
    Wan-Jin Jeon et al, 2017, Life Sciences CrossRef
  15. The flavonol glycoside icariin promotes bone formation in growing rats by activating the cAMP signaling pathway in primary cilia of osteoblasts
    Wengui Shi et al, 2017, J. Biol. Chem. CrossRef
  16. Natural Products from Chinese Medicines with Potential Benefits to Bone Health
    Chun-Tao Che et al, 2016, Molecules CrossRef
  17. Prevention and Treatment of Osteoporosis Using Chinese Medicinal Plants: Special Emphasis on Mechanisms of Immune Modulation
    Hongyan Zhao et al, 2018, Journal of Immunology Research CrossRef
  18. Icariin, but Not Genistein, Exerts Osteogenic and Anti-apoptotic Effects in Osteoblastic Cells by Selective Activation of Non-genomic ERα Signaling
    Ming-Xian Ho et al, 2018, Front. Pharmacol. CrossRef
  19. The Role of Semipurified Fractions Isolated from Quercus infectoria on Bone Metabolism by Using hFOB 1.19 Human Fetal Osteoblast Cell Model
    Amira Raudhah Abdullah et al, 2018, Evidence-Based Complementary and Alternative Medicine CrossRef
  20. Icariin: a Potential Compound for the Recovery of Tibial Dyschondroplasia Affected Chicken Via Up-Regulating BMP-2 Expression
    Mujahid Iqbal et al, 2018, Biol Proced Online CrossRef
  21. Icariin loaded-hollow bioglass/chitosan therapeutic scaffolds promote osteogenic differentiation and bone regeneration
    He Xu et al, 2018, Chemical Engineering Journal CrossRef
  22. null
    Sajad Ahmad Lone et al, 2018 CrossRef
  23. Cordycepin Accelerates Osteoblast Mineralization and Attenuates Osteoclast Differentiation In Vitro
    Su-Bin Yu et al, 2018, Evidence-Based Complementary and Alternative Medicine CrossRef
  24. Downregulation of miR-24-3p promotes osteogenic differentiation of human periodontal ligament stem cells by targeting SMAD family member 5
    Zhaobao Li et al, 2018, J Cell Physiol CrossRef
  25. Effect of Total Flavonoids of Rhizoma drynariae on Tibial Dyschondroplasia by Regulating BMP-2 and Runx2 Expression in Chickens
    Wangyuan Yao et al, 2018, Front. Pharmacol. CrossRef
  26. Flavonoids from the leaves of Epimedium Koreanum Nakai and their potential cytotoxic activities
    Huaran Zhang et al, 2019, Natural Product Research CrossRef
  27. Osteogenic Enhancement Between Icariin and Bone Morphogenetic Protein 2: A Potential Osteogenic Compound for Bone Tissue Engineering
    Xin Zhang et al, 2019, Front. Pharmacol. CrossRef
  28. Effects of miR-146a on the osteogenesis of adipose-derived mesenchymal stem cells and bone regeneration.
    Qing Xie et al, 0 CrossRef
  29. Chemical Constituents, Quality Control, and Bioactivity of Epimedii Folium (Yinyanghuo)
    Xiao-Jia Chen et al, 2015, Am. J. Chin. Med. CrossRef
  30. Icariin: Does It Have An Osteoinductive Potential for Bone Tissue Engineering?
    Xin Zhang et al, 2014, Phytother. Res. CrossRef
  31. Bone Protective Effect of Extra-Virgin Olive Oil Phenolic Compounds by Modulating Osteoblast Gene Expression
    null Melguizo-Rodríguez et al, 2019, Nutrients CrossRef
  32. Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii.
    Chenrui Li et al, 2015, Life Sci CrossRef
  33. Osthole: A Coumarin Derivative Assuage Thiram-Induced Tibial Dyschondroplasia by Regulating BMP-2 and RUNX-2 Expressions in Chickens
    Muhammad Waqas et al, 2019, Antioxidants CrossRef
  34. Small molecules and their controlled release that induce the osteogenic/chondrogenic commitment of stem cells
    Yingjun Wang et al, 2015, Biotechnology Advances CrossRef
  35. Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation
    Jing An et al, 2016, Life Sciences CrossRef
  36. Coordinate regulatory osteogenesis effects of icariin, timosaponin B II and ferulic acid from traditional Chinese medicine formulas on UMR-106 osteoblastic cells and osteoblasts in neonatal rat calvaria cultures
    Mei Li et al, 2016, Journal of Ethnopharmacology CrossRef
  37. Seropharmacological study on osteogenic effects of post-absorption ingredients of an osteoprotective herbal formula
    Wing-sum Siu et al, 2017, Chin. J. Integr. Med. CrossRef
  38. Flavonoids of Herba Epimedii Enhances Bone Repair in a Rabbit Model of Chronic Osteomyelitis During Post-infection Treatment and Stimulates Osteoblast Proliferation in Vitro.
    Dan Shou et al, 0 CrossRef
  39. Icariin protects against glucocorticoid induced osteoporosis, increases the expression of the bone enhancer DEC1 and modulates the PI3K/Akt/GSK3β/β-catenin integrated signaling pathway.
    Jinhua Hu et al, 0 CrossRef
  40. Phlorofucofuroeckol A from Edible Brown Alga Ecklonia Cava Enhances Osteoblastogenesis in Bone Marrow-Derived Human Mesenchymal Stem Cells
    Jung Hwan Oh et al, 2019, Marine Drugs CrossRef
  41. Icariin Promotes the Osteogenic Action of BMP2 by Activating the cAMP Signaling Pathway.
    Meng Chen et al, 2019, Molecules CrossRef
  42. Therapeutic Anabolic and Anticatabolic Benefits of Natural Chinese Medicines for the Treatment of Osteoporosis.
    Jianbo He et al, 2019, Front Pharmacol CrossRef
  43. Agrimonia pilosa polysaccharide and its sulfate derives facilitate cell proliferation and osteogenic differentiation of MC3T3-E1 cells by targeting miR-107
    Wei Huang et al, 2019, International Journal of Biological Macromolecules CrossRef
  44. The BMP signaling pathway enhances the osteoblastic differentiation of bone marrow mesenchymal stem cells in rats with osteoporosis
    Bin Zhao et al, 2019, J Orthop Surg Res CrossRef
  45. Icariin prevents oestrogen deficiency–induced alveolar bone loss through promoting osteogenesis via STAT3
    Hongyuan Xu et al, 2020, Cell Prolif CrossRef
  46. Protective effect of Agrimonia pilosa polysaccharides on dexamethasone‐treated MC3T3‐E1 cells via Wnt/β‐Catenin pathway
    Wei Huang et al, 2020, J Cell Mol Med CrossRef
  47. The effects of fibrin–icariin nanoparticle loaded in poly (lactic-co-glycolic) acid scaffold as a localized delivery system on chondrogenesis of human adipose-derived stem cells
    Mona Gorji et al, 2020, Adv Biomed Res CrossRef
  48. The Role of Tantalum Nanoparticles in Bone Regeneration Involves the BMP2/Smad4/Runx2 Signaling Pathway


    Guilan Zhang et al, 2020, IJN CrossRef
  49. Icariin promotes the proliferation and differentiation of osteoblasts from the rat mandible by the Wnt/β‑catenin signalling pathway
    Yue Wang et al, 2018, Mol Med Report CrossRef
  50. Gastrodin protects MC3T3-E1 osteoblasts from dexamethasone-induced cellular dysfunction and promotes bone formation via induction of the NRF2 signaling pathway.
    Shengye Liu et al, 0 CrossRef
  51. Icariin regulates the osteoblast differentiation and cell proliferation of MC3T3‑E1 cells through microRNA‑153 by targeting Runt‑related transcription factor 2
    Zengfa Huang et al, 2018, Exp Ther Med CrossRef
  52. In Vitro and In Vivo Osteogenesis Induced by Icariin and Bone Morphogenetic Protein-2: A Dynamic Observation
    Lina Xie et al, 2020, Front. Pharmacol. CrossRef
  53. Systemic osteoprotective effects of Epimedii Folium and Ligustri Lucidi Fructus in senile osteoporosis rats by promoting the osteoblastogenesis and osteoclastogenesis based on MLP-ANN model
    Xiu-Feng Tang et al, 2020, Chin Med CrossRef
  54. Small Molecule–Mediated Enhanced Osteogenesis of Human Mesenchymal Stem Cells: a Probable Alternate for BMP-2
    Pearlin Hameed et al, 2020, Regen. Eng. Transl. Med. CrossRef
  55. Daidzein induces bone morphogenetic protein-2 and runt-related transcription 2 on periodontal ligament cells after experimental tooth movement
    Mioko Sakurai et al, 2020, Orthodontic Waves CrossRef
  56. Botanicals in Postmenopausal Osteoporosis.
    Wojciech Słupski et al, 2021, Nutrients CrossRef
  57. MiR-183 regulates the differentiation of osteoblasts in the development of osteoporosis by targeting Smad4
    Xia-Bing Qin et al, 2021, Acta Histochemica CrossRef
  58. Tradition to Pathogenesis: A Novel Hypothesis for Elucidating the Pathogenesis of Diseases Based on the Traditional Use of Medicinal Plants
    Kenny Kuchta et al, 2021, Front. Pharmacol. CrossRef
  59. Role of Traditional Chinese Medicine in Bone Regeneration and Osteoporosis
    Zhicai Peng et al, 2022, Front. Bioeng. Biotechnol. CrossRef
  60. Comprehensive analysis of the m6A-related molecular patterns and diagnostic biomarkers in osteoporosis
    Qiong Bai et al, 2022, Front. Endocrinol. CrossRef
  61. Apigenin Promotes Proliferation and Mineralization of Human Osteoblasts and Up-Regulates Osteogenic Markers
    Emira D’Amico et al, 2022, Applied Sciences CrossRef
  62. Icariin: A Potential Alternative Against Osteoporosis
    Longhai Long et al, 2022, Natural Product Communications CrossRef
  63. Gut microbiota and calcium balance
    Jiali Wang et al, 2022, Front. Microbiol. CrossRef
  64. Post-Transcriptional Regulatory Crosstalk between MicroRNAs and Canonical TGF-β/BMP Signalling Cascades on Osteoblast Lineage: A Comprehensive Review
    Hui-Yi Loh et al, 2023, IJMS CrossRef
  65. Icariin promotes osteogenic differentiation by upregulating alpha-enolase expression
    Dingbang Xie et al, 2023, Biochemistry and Biophysics Reports CrossRef
  66. Sustainable Bioactive Composite of Glehnia littoralis Extracts for Osteoblast Differentiation and Bone Formation
    Chul Joong Kim et al, 2023, Processes CrossRef
  67. Icariin Promotes Osteogenic Differentiation in a Cell Model with NF1 Gene Knockout by Activating the cAMP/PKA/CREB Pathway
    Meng Chen et al, 2023, Molecules CrossRef
  68. Promoting osteogenesis and bone regeneration employing icariin-loaded nanoplatforms
    Mahsa Mohammadzadeh et al, 2024, J Biol Eng CrossRef
  69. Comparison of the Anabolic Effects of Reported Osteogenic Compounds on Human Mesenchymal Progenitor-Derived Osteoblasts
    Robert Owen et al, 2020, Bioengineering CrossRef
  70. Enhancing osteoporosis treatment using a targeted, sustained-release drug delivery system based on macrocyclic amphiphile
    Gan Luo et al, 2024, International Journal of Pharmaceutics CrossRef