1. MPA Modulates Tight Junctions' Permeability via Midkine/PI3K Pathway in Caco-2 Cells: A Possible Mechanism of Leak-Flux Diarrhea in Organ Transplanted Patients
    Niamat Khan et al, 2017, Front. Physiol. CrossRef
  2. PI3K/AKT signaling mediated by G protein‑coupled receptors is involved in neurodegenerative Parkinson's disease (Review).
    Noriko Nakano et al, 2017, Int J Mol Med CrossRef
  3. MicroRNA-141 Is Involved in Ulcerative Colitis Pathogenesis via Aiming at CXCL5
    Mao Cai et al, 2017, Journal of Interferon & Cytokine Research CrossRef
  4. Protective role of liriodendrin in mice with dextran sulphate sodium-induced ulcerative colitis.
    Zhen Zhang et al, 2017, Int Immunopharmacol CrossRef
  5. In vitro and in vivo inhibitory activity of 6-amino-2,4,5-trimethylpyridin-3-ols against inflammatory bowel disease
    Suhrid Banskota et al, 2016, Bioorganic & Medicinal Chemistry Letters CrossRef
  6. Myeloperoxidase in the inflamed colon: A novel target for treating inflammatory bowel disease
    Belal Chami et al, 2018, Archives of Biochemistry and Biophysics CrossRef
  7. Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells Regulation.
    Satoru Matsuda et al, 2018, Cells CrossRef
  8. LL202 ameliorates colitis against oxidative stress of macrophage by activation of the Nrf2/HO-1 pathway
    Yuan Gao et al, 2018, J Cell Physiol CrossRef
  9. Brefeldin A reduces tumor necrosis factor-α-stimulated production of inflammatory mediators by suppressing the Akt, mTOR, and NF-κB pathways in human keratinocytes
    Yoon Jeong Nam et al, 2016, Naunyn-Schmiedeberg's Arch Pharmacol CrossRef
  10. Flavonoid myricetin inhibits TNF-α-stimulated production of inflammatory mediators by suppressing the Akt, mTOR and NF-κB pathways in human keratinocytes
    Da Hee Lee et al, 2016, European Journal of Pharmacology CrossRef
  11. Inflammatory Bowel Disease: Updates on Molecular Targets for Biologics
    Konstantinos H. Katsanos et al, 2017, Gut and Liver CrossRef
  12. Genetic variation and expression levels of tight junction genes identifies association between MAGI3 and inflammatory bowel disease
    Elisabeth Norén et al, 2017, BMC Gastroenterol CrossRef
  13. Phosphatase and tensin homolog (PTEN) is down-regulated in human NK/T-cell lymphoma and corrects with clinical outcomes
    Xiaorui Fu et al, 2017, Medicine CrossRef
  14. PTEN Inhibits Inflammatory Bone Loss in Ligature-Induced Periodontitis via IL1 and TNF-α
    Chuanyun Fu et al, 2019, BioMed Research International CrossRef
  15. Combination of tanshinone IIA and astragaloside IV attenuate atherosclerotic plaque vulnerability in ApoE(-/-) mice by activating PI3K/AKT signaling and suppressing TRL4/NF-κB signaling
    Nanding Wang et al, 2020, Biomedicine & Pharmacotherapy CrossRef
  16. Altered microbial community structure in PI3Kγ knockout mice with colitis impeding relief of inflammation: Establishment of new indices for intestinal microbial disorder
    Yi Li et al, 2020, International Immunopharmacology CrossRef
  17. Macrophage-based nanotherapeutic strategies in ulcerative colitis
    Jiaxin Zhang et al, 2020, Journal of Controlled Release CrossRef
  18. Degeneration of the intestinal microbial community in PI3Kγ-knockout mice
    Yi Li et al, 2020, Microbial Pathogenesis CrossRef
  19. Abdominal paracentesis drainage attenuates severe acute pancreatitis by enhancing cell apoptosis via PI3K/AKT signaling pathway.
    Chen Luo et al, 2020, Apoptosis CrossRef
  20. Ccr6 Deficiency Attenuates Spontaneous Chronic Colitis in Winnie
    Ranmali Ranasinghe et al, 2020, GastrointestDisord CrossRef
  21. Current Status of M1 and M2 Macrophages Pathway as Drug Targets for Inflammatory Bowel Disease
    Seyede Sara Seyedizade et al, 2020, Arch. Immunol. Ther. Exp. CrossRef
  22. Ferulic Acid Ameliorates Lipopolysaccharide-Induced Barrier Dysfunction via MicroRNA-200c-3p-Mediated Activation of PI3K/AKT Pathway in Caco-2 Cells
    Shasha He et al, 2020, Front. Pharmacol. CrossRef
  23. Regulatory effects of Ganoderma atrum polysaccharides on LPS-induced inflammatory macrophages model and intestinal-like Caco-2/macrophages co-culture inflammation model
    Xiaoyi Hu et al, 2020, Food and Chemical Toxicology CrossRef
  24. Experimental Study on the Effect of Aconite and Angelica sinensis on Myocardial Ischemia Rats with Yang Deficiency and Blood Stasis
    Yongcang Cao et al, 2020, Evidence-Based Complementary and Alternative Medicine CrossRef
  25. NOD2 deficiency exacerbates hypoxia-induced pulmonary hypertension and enhances pulmonary vascular smooth muscle cell proliferation.
    Min-Young Kwon et al, 2018, Oncotarget CrossRef
  26. PIK3R3 regulates ZO-1 expression through the NF-kB pathway in inflammatory bowel disease
    Sidikjan Ibrahim et al, 2020, International Immunopharmacology CrossRef
  27. Diet induces hepatocyte protection in fatty liver disease via modulation of PTEN signaling (Review)
    Yuka Ikeda et al, 2020, biom rep CrossRef
  28. Role of RING-Type E3 Ubiquitin Ligases in Inflammatory Signalling and Inflammatory Bowel Disease
    Liguo Zhu et al, 2020, Mediators of Inflammation CrossRef
  29. Pinpointing miRNA and genes enrichment over trait-relevant tissue network in Genome-Wide Association Studies
    Binze Li et al, 2020, BMC Med Genomics CrossRef
  30. Vildagliptin attenuates acetic acid-induced colitis in rats via targeting PI3K/Akt/NFκB, Nrf2 and CREB signaling pathways and the expression of lncRNA IFNG-AS1 and miR-146a
    Marina R. Fouad et al, 2021, International Immunopharmacology CrossRef
  31. Dysregulated microRNA expression in IL-4 transgenic mice, an animal model of atopic dermatitis
    Lei Bao et al, 2021, Arch Dermatol Res CrossRef
  32. Treatment of Immune Dysregulation Due to a PTEN Variant with Sirolimus
    Jonathan S. Emerson et al, 2021, J Clin Immunol CrossRef
  33. The PI3K pathway as a therapeutic intervention point in inflammatory bowel disease
    Paula Winkelmann et al, 2021, Immun Inflamm Dis CrossRef
  34. E3 ligase activity of Carboxyl terminus of Hsc70 interacting protein ( CHIP) in Wharton's jelly derived mesenchymal stem cells improves their persistence under hyperglycemic stress and promotes the prophylactic effects against diabetic cardiac damages
    Ayaz Ali et al, 2021, Bioeng Transl Med CrossRef
  35. PTEN as a Therapeutic Target in Pulmonary Hypertension Secondary to Left-heart Failure: Effect of HO-3867 and Supplemental Oxygenation
    Yazhini Ravi et al, 2021, Cell Biochem Biophys CrossRef
  36. Wogonin Strengthens the Therapeutic Effects of Mesenchymal Stem Cells in DSS-Induced Colitis via Promoting IL-10 Production
    Qiongli Wu et al, 2021, Oxidative Medicine and Cellular Longevity CrossRef
  37. Prolonged Chronic Consumption of a High Fat with Sucrose Diet Alters the Morphology of the Small Intestine.
    Roberta Sferra et al, 2021, Int J Mol Sci CrossRef
  38. Specific Plasma MicroRNA Signatures in Predicting and Confirming Crohn's Disease Recurrence: Role and Pathogenic Implications
    Inés Moret-Tatay et al, 2021, Clin Transl Gastroenterol CrossRef
  39. Overexpression of circAtp9b in ulcerative colitis is induced by lipopolysaccharides and upregulates PTEN to promote the apoptosis of colonic epithelial cells
    Fengdong Li et al, 2021, Exp Ther Med CrossRef
  40. The PI3K/AKT Pathway and PTEN Gene Are Involved in “Tree-Top Disease” of Lymantria dispar
    Fengjiao Li et al, 2022, Genes CrossRef
  41. Effects of Growth Stage on the Characterization of Enterotoxin A-Producing Staphylococcus aureus-Derived Membrane Vesicles
    Yuka Yamanashi et al, 2022, Microorganisms CrossRef
  42. Emerging role of protein modification in inflammatory bowel disease
    Gaoying Wang et al, 2022, J. Zhejiang Univ. Sci. B CrossRef
  43. Galangin alleviates rheumatoid arthritis in rats by downregulating the phosphatidylinositol 3-kinase/protein kinase B signaling pathway
    Xiongwei Deng et al, 2022, Bioengineered CrossRef
  44. Citrus unshiu Peel Attenuates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice due to Modulation of the PI3K/Akt Signaling Pathway and MAPK and NF-κB
    Se Hui Lee et al, 2022, Evidence-Based Complementary and Alternative Medicine CrossRef
  45. Renshen Baidu Powder Attenuated Intestinal Inflammation and Apoptosis in Ulcerative Colitis Rats through the Inhibition of PI3K/AKT/NF-κB Signaling Pathway
    Peixu Zhang et al, 2022, Evidence-Based Complementary and Alternative Medicine CrossRef
  46. Traditional Chinese Medicine and Natural Products: Potential Approaches for Inflammatory Bowel Disease
    Shuo Yuan et al, 2022, Front. Pharmacol. CrossRef
  47. Euphorbium total triterpenes improve Freund's complete adjuvant-induced arthritis through PI3K/AKT/Bax and NF-κB/NLRP3 signaling pathways
    Maojie Zhou et al, 2023, Journal of Ethnopharmacology CrossRef
  48. Investigate the genetic mechanisms of diabetic kidney disease complicated with inflammatory bowel disease through data mining and bioinformatic analysis
    Xiaoyu Zhang et al, 2023, Front. Endocrinol. CrossRef
  49. Calorie restriction alters the mechanisms of radiation-induced mouse thymic lymphomagenesis
    Takafumi Nakayama et al, 2023, PLoS ONE CrossRef
  50. Helixor-M Suppresses Immunostimulatory Activity through TLR4-Dependent NF-κB Pathway in RAW 264.7 Cells
    Doil Park et al, 2023, Life CrossRef
  51. The Exosome-Mediated PI3K/Akt/mTOR Signaling Pathway in Neurological Diseases
    Amin Iranpanah et al, 2023, Pharmaceutics CrossRef
  52. Radix Pueraria lobata polysaccharide relieved DSS-induced ulcerative colitis through modulating PI3K signaling
    Zhuang Zhang et al, 2023, Journal of Functional Foods CrossRef
  53. NOD2 in monocytes negatively regulates macrophage development through TNFalpha
    Camille Chauvin et al, 2023, Front. Immunol. CrossRef
  54. Moringa oleifera leaf polysaccharide regulates fecal microbiota and colonic transcriptome in calves
    Chao Zhao et al, 2023, International Journal of Biological Macromolecules CrossRef
  55. Toxicity assessment of organophosphate flame retardant triphenyl phosphate (TPHP) on intestines in mice
    Chunyan Peng et al, 2023, Ecotoxicology and Environmental Safety CrossRef
  56. Presence of crown-like structures in breast adipose tissue; differences between healthy controls, BRCA1/2 gene mutation carriers and breast cancer patients
    Mieke C. Zwager et al, 2023, Breast Cancer Res Treat CrossRef
  57. Maternal immune activation mediated prenatal chronic stress induces Th17/Treg cell imbalance may relate to the PI3K/Akt/NF-κB signaling pathway in offspring rats
    Ye Li et al, 2024, International Immunopharmacology CrossRef
  58. Co-occurrence of leukemia, Crohn’s disease, and tuberous sclerosis in one patient
    Yoon Ji Ahn et al, 2023, Precis Future Med CrossRef
  59. Sophoricoside improved Crohn's disease-like colitis by inhibiting intestinal epithelial cell apoptosis through PI3K/AKT signaling
    Qingqing Li et al, 2024, International Immunopharmacology CrossRef