1. Metformin: A Novel but Controversial Drug in Cancer Prevention and Treatment
    Xinbing Sui et al, 2015, Mol. Pharmaceutics CrossRef
  2. Metformin inhibits prostate cancer cell proliferation, migration, and tumor growth through upregulation of PEDF expression
    Xiaowan Chen et al, 2016, Cancer Biology & Therapy CrossRef
  3. Negative regulation of Sirtuin 1 by AMP-activated protein kinase promotes metformin-induced senescence in hepatocellular carcinoma xenografts
    Xinke Zhou et al, 2017, Cancer Letters CrossRef
  4. Role of metformin on base excision repair pathway in p53 wild-type H2009 and HepG2 cancer cells
    ID Turacli et al, 2017, Hum Exp Toxicol CrossRef
  5. Dose-Dependent Relationship Between Metformin and Colorectal Cancer Occurrence Among Patients with Type 2 Diabetes—A Nationwide Cohort Study
    Yu-Tang Chang et al, 2018, Translational Oncology CrossRef
  6. SIRT1 and microRNAs: the role in breast, lung and prostate cancers
    Hedyieh Karbasforooshan et al, 2018, Experimental Cell Research CrossRef
  7. Band Alignment-Driven Oxidative Injury to the Skin by Anatase/Rutile Mixed-Phase Titanium Dioxide Nanoparticles Under Sunlight Exposure
    Xiujuan Sun et al, 2018 CrossRef
  8. Protein phosphatase 5 promotes hepatocarcinogenesis through interaction with AMP-activated protein kinase
    Yao-Li Chen et al, 2017, Biochemical Pharmacology CrossRef
  9. null
    Renato Heidor et al, 2019 CrossRef
  10. Rosiglitazone metformin adduct inhibits hepatocellular carcinoma proliferation via activation of AMPK/p21 pathway
    Yuyang Liu et al, 2019, Cancer Cell Int CrossRef
  11. Senolytics and senostatics as adjuvant tumour therapy
    Susan Short et al, 2019, EBioMedicine CrossRef
  12. 6-Bromoindirubin-3′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver
    Donghao Guo et al, 2019, Front. Pharmacol. CrossRef
  13. The Role of AMP-Activated Protein Kinase as a Potential Target of Treatment of Hepatocellular Carcinoma
    Xue Jiang et al, 2019, Cancers CrossRef
  14. null
    Jin Rong Ow et al, 2014 CrossRef
  15. 6-Gingerol inhibits osteosarcoma cell proliferation through apoptosis and AMPK activation
    Jingzhang Fan et al, 2015, Tumor Biol. CrossRef
  16. Metformin Treatment for the Prevention and/or Treatment of Breast/Mammary Tumorigenesis
    Michael E. Grossmann et al, 2015, Curr Pharmacol Rep CrossRef
  17. Impact of insulin resistance on hepatocellular carcinoma
    Takumi Kawaguchi et al, 2015, Acta hepatologica Japonica CrossRef
  18. Combination Therapy of Metformin and Statin May Decrease Hepatocellular Carcinoma Among Diabetic Patients in Asia
    Hsin-Hung Chen et al, 2015, Medicine CrossRef
  19. Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions
    Robert Haas et al, 2015, PLoS Biol CrossRef
  20. Metformin: A Novel Biological Modifier of Tumor Response to Radiation Therapy
    Marianne Koritzinsky, 2015, International Journal of Radiation Oncology*Biology*Physics CrossRef
  21. Effects of Epothilone A in Combination with the Antidiabetic Drugs Metformin and Sitagliptin in HepG2 Human Hepatocellular Cancer Cells: Role of Transcriptional Factors NF-κB and p53
    Aneta Rogalska et al, 2016, Asian Pacific Journal of Cancer Prevention CrossRef
  22. The Potential Effect of Metformin on Cancer: An Umbrella Review
    Hong Yu et al, 2019, Front. Endocrinol. CrossRef
  23. Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights
    Ntsoaki Annah Nyane et al, 2017, European Journal of Pharmacology CrossRef
  24. Palbociclib induces activation of AMPK and inhibits hepatocellular carcinoma in a CDK4/6-independent manner.
    Feng-Shu Hsieh et al, 0 CrossRef
  25. SIRT1 in the Development and Treatment of Hepatocellular Carcinoma
    Marius Farcas et al, 2019, Front. Nutr. CrossRef
  26. LKB1/AMPK Pathway and Drug Response in Cancer: A Therapeutic Perspective
    Francesco Ciccarese et al, 2019, Oxidative Medicine and Cellular Longevity CrossRef
  27. Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway
    Yuanyuan Liu et al, 2019, Life Sciences CrossRef
  28. Metformin: The Answer to Cancer in a Flower? Current Knowledge and Future Prospects of Metformin as an Anti-Cancer Agent in Breast Cancer
    Samson Mathews Samuel et al, 2019, Biomolecules CrossRef
  29. Natural Polyphenols Targeting Senescence: A Novel Prevention and Therapy Strategy for Cancer
    Yan Bian et al, 2020, IJMS CrossRef
  30. Repurposing drugs for the treatment of glioma
    Chengming Xu et al, 2019, Glioma CrossRef
  31. Benefits of Metformin in Attenuating the Hallmarks of Aging
    Ameya S. Kulkarni et al, 2020, Cell Metabolism CrossRef
  32. Metformin activates AMPK/SIRT1/NF-κB pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis
    Zhaodi Zheng et al, 2020, Cell Cycle CrossRef
  33. The Anti-Breast Cancer Effect and Mechanism of Glimepiride-Metformin Adduct


    Liangyuan Long et al, 2020, OTT CrossRef
  34. p53 and metabolism: from mechanism to therapeutics
    Fernando M. Simabuco et al, 2018, Oncotarget CrossRef
  35. Anti-tumor activity of metformin: from metabolic and epigenetic perspectives
    Xilan Yu et al, 2017, Oncotarget CrossRef
  36. Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells
    Mamatha Bhat et al, 2017, Oncotarget CrossRef
  37. Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma
    Xinke Zhou et al, 2016, Oncotarget CrossRef
  38. Metformin sensitizes lung cancer cells to treatment by the tyrosine kinase inhibitor erlotinib
    Xiaofei Wang et al, 2017, Oncotarget CrossRef
  39. Prognostic significance of AMPK in human malignancies: A meta-analysis
    Ji Cheng et al, 2016, Oncotarget CrossRef
  40. Targeting AMPK for cancer prevention and treatment
    Weidong Li et al, 2015, Oncotarget CrossRef
  41. Hemistepsin A Inhibits Cell Proliferation and Induces G0/G1-Phase Arrest, Cellular Senescence and Apoptosis Via the AMPK and p53/p21 Signals in Human Hepatocellular Carcinoma
    Su Youn Baek et al, 2020, Biomolecules CrossRef
  42. 4-Acetylantrocamol LT3, a New Ubiquinone from Antrodia cinnamomea, Inhibits Hepatocellular Carcinoma HepG2 Cell Growth by Targeting YAP/TAZ, mTOR, and WNT/β-Catenin Signaling
    Yen-Lin Chen et al, 2020, Am. J. Chin. Med. CrossRef
  43. Non-circadian aspects of BHLHE40 cellular function in cancer
    Zsofia Kiss et al, 2020, Genes Cancer CrossRef
  44. Counteracting Chemoresistance with Metformin in Breast Cancers: Targeting Cancer Stem Cells
    Samson Mathews Samuel et al, 2020, Cancers CrossRef
  45. Metabolism and immunity in breast cancer
    Deyu Zhang et al, 2020, Front. Med. CrossRef
  46. Metformin Inhibits Cellular Proliferation and Bioenergetics in Colorectal Cancer Patient–Derived Xenografts
    Nur-Afidah Mohamed Suhaimi et al, 2017, Mol Cancer Ther CrossRef
  47. Sensitivity of pancreatic cancer cells to chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals can Be regulated by WT-TP53
    Stephen L. Abrams et al, 2021, Advances in Biological Regulation CrossRef
  48. Acidosis‐induced activation of distal nephron principal cells triggers Gdf15 secretion and adaptive proliferation of intercalated cells
    Lydie Cheval et al, 2021, Acta Physiol CrossRef
  49. Metformin improves the therapeutic efficacy of low-dose albendazole against experimental alveolar echinococcosis
    Julia A. Loos et al, 2021, Parasitology CrossRef
  50. Temozolomide abrogates the aggressiveness of urothelial carcinoma cells by enhancing senescence and depleting the side population
    Na-Yon Kim et al, 2021, Oncol Lett CrossRef
  51. The Gut Microbiome, Metformin, and Aging
    Sri Nitya Reddy Induri et al, 2022, Annu. Rev. Pharmacol. Toxicol. CrossRef
  52. Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1)
    Nerea Allende-Vega et al, 2022, Sci Rep CrossRef
  53. A new contribution for an old drug: Prospect of metformin in colorectal oncotherapy
    Shangze Jiang et al, 2021, J Can Res Ther CrossRef
  54. Metformin Induces PRODH/POX-Dependent Apoptosis in Breast Cancer Cells
    Thi Yen Ly Huynh et al, 2022, Front. Mol. Biosci. CrossRef
  55. Mechanisms of cancer cell killing by metformin: a review on different cell death pathways
    Xiao-yu Wu et al, 2022, Mol Cell Biochem CrossRef
  56. Association of sirtuins (SIRT1-7) with lung and intestinal diseases
    Yuhan Chen et al, 2022, Mol Cell Biochem CrossRef
  57. Repurposing Drugs in Small Animal Oncology
    Antonio Giuliano et al, 2022, Animals CrossRef
  58. Metformin Induces Apoptosis in Human Pancreatic Cancer (PC) Cells Accompanied by Changes in the Levels of Histone Acetyltransferases (Particularly, p300/CBP-Associated Factor (PCAF) Protein Levels)
    Izabela Szymczak-Pajor et al, 2023, Pharmaceuticals CrossRef
  59. Radiation-induced senescence: therapeutic opportunities
    Jae Ho Kim et al, 2023, Radiat Oncol CrossRef
  60. Pleiotropic Effects of Metformin in Osteoarthritis
    Sevdalina Nikolova Lambova, 2023, Life CrossRef
  61. Antitumor activity of Metformin through p53 and Cyclin D1 in the Urothelial Cell Carcinoma
    Anny Setijo Rahaju et al, 2023, RJPT CrossRef
  62. Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing
    Yu Hua et al, 2023, J Transl Med CrossRef
  63. Prognostic role of metformin in diabetes mellitus type 2 patients with hepatocellular carcinoma: A systematic review and meta-analysis
    Maja Cigrovski Berkovic et al, 2023, World J Diabetes CrossRef
  64. Integrated Stress Response (ISR) Pathway: Unraveling Its Role in Cellular Senescence
    Alexander Kalinin et al, 2023, IJMS CrossRef
  65. Biochemical and transcriptomic evaluation of a 3D lung organoid platform for pre-clinical testing of active substances targeting senescence
    Michelle Brand et al, 2024, Respir Res CrossRef
  66. Phytol and (−)-α-bisabolol Synergistically trigger intrinsic apoptosis through redox and Ca2+ imbalance in non-small cell lung cancer
    Chandramohan Kiruthiga et al, 2024, Biocatalysis and Agricultural Biotechnology CrossRef