1. Succinyl-5-aminoimidazole-4-carboxamide-1-ribose 5′-Phosphate (SAICAR) Activates Pyruvate Kinase Isoform M2 (PKM2) in Its Dimeric Form
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2. Santamarine Inhibits NF-κB Activation and Induces Mitochondrial Apoptosis in A549 Lung Adenocarcinoma Cells via Oxidative Stress
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3. Collateral Damage Intended—Cancer-Associated Fibroblasts and Vasculature Are Potential Targets in Cancer Therapy
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4. IGF-1-mediated PKM2/β-catenin/miR-152 regulatory circuit in breast cancer
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5. Structural Investigation of a Dimeric Variant of Pyruvate Kinase Muscle Isoform 2
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6. Oncogene-Driven Metabolic Alterations in Cancer
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7. FFJ-3 inhibits PKM2 protein expression via the PI3K/Akt signaling pathway and activates the mitochondrial apoptosis signaling pathway in human cancer cells
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8. Pulmonary Hypertension Associated With Scleroderma and Connective Tissue Disease: Potential Molecular and Cellular Targets
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9. Metabolic phenotyping of CHO cells varying in cellular biomass accumulation and maintenance during fed-batch culture
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10. AKT2 contributes to increase ovarian cancer cell migration and invasion through the AKT2-PKM2-STAT3/NF-κB axis
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11. GLP2 Promotes Directed Differentiation from Osteosarcoma Cells to Osteoblasts and Inhibits Growth of Osteosarcoma Cells
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12. Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting β-catenin by activating PKM2 and inactivating PTEN
    Qidi Zheng et al, 2018, Cell Death Dis CrossRef
13. Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling
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14. Hepatic glucose-6-phosphatase-α deficiency leads to metabolic reprogramming in glycogen storage disease type Ia
    Jun-Ho Cho et al, 2018, Biochemical and Biophysical Research Communications CrossRef
15. Metabolic Reprogramming in Thyroid Carcinoma
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16. The Warburg Effect in Diabetic Kidney Disease
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17. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways
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18. The Warburg effect and glucose-derived cancer theranostics
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19. Including the mitochondrial metabolism of l-lactate in cancer metabolic reprogramming
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20. Enzyme targeting strategies for prevention and treatment of cancer: Implications for cancer therapy.
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21. Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities After Ischemic Stroke in Adult Mice
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22. A Novel Multiple-Read Screen for Metabolically Active Compounds Based on a Genetically Encoded FRET Sensor for ATP
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23. Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer
    Bo-wen Liu et al, 2018, Acta Pharmacol Sin CrossRef
24. Hidden features: exploring the non-canonical functions of metabolic enzymes
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25. Constitutive androstane receptor activation evokes the expression of glycolytic genes
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26. Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming
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27. Emerging roles of Myc in stem cell biology and novel tumor therapies.
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28. Mechanisms contributing to persistently activated cell phenotypes in pulmonary hypertension
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29. In Vitro Modulation of Redox and Metabolism Interplay at the Brain Vascular Endothelium: Genomic and Proteomic Profiles of Sulforaphane Activity
    Ravi K. Sajja et al, 2018, Sci Rep CrossRef
30. Environmentally relevant concentrations of carbamazepine induce liver histopathological changes and a gender-specific response in hepatic proteome of Chinese rare minnows (Gobiocypris rarus)
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31. An Update on Patents Covering Agents That Interfere with the Cancer Glycolytic Cascade
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32. Colorectal Cancer and Metabolism
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33. Identification of Protein Abundance Changes in Hepatocellular Carcinoma Tissues Using PCT-SWATH
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34. miR-625-5p/PKM2 negatively regulates melanoma glycolysis state
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35. The reduced activity of PP-1α under redox stress condition is a consequence of GSH-mediated transient disulfide formation
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36. Human asparagine synthetase associates with the mitotic spindle
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37. Non-canonical localization of PKM2 in cancer progression: Mechanism of nuclear translocation
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38. Overexpression of Pyruvate Kinase M2 in Tumor Tissues Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma
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40. Glucagon-Induced Acetylation of Energy-Sensing Factors in Control of Hepatic Metabolism
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41. A New Compound-ensemble Strategy for Validating Cancer Drug Targets Confirms that Inhibiting Glycolysis Blocks Leukemic Cell Proliferation.
    Ziyan Zhao et al, 2018, SSRN Journal CrossRef
42. Breaking Glucose Transporter 1/Pyruvate Kinase M2 Glycolytic Loop Is Required for Cantharidin Inhibition of Metastasis in Highly Metastatic Breast Cancer
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43. Evolutionary engineering of Corynebacterium glutamicum
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44. Enhanced penetration and cytotoxicity of metformin and collagenase conjugated gold nanoparticles in breast cancer spheroids
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46. PKM2, function and expression and regulation
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47. FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis.
    Alex Cordero et al, 2019, Oncogene CrossRef
48. Beta‐elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation
    Yanhong Pan et al, 2019, J Cell Mol Med CrossRef
49. Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism
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50. Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2
    Dhiraj Srivastava et al, 2019, Biochemistry CrossRef
51. Metabolic Plasticity of Acute Myeloid Leukemia
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52. Redox rebalance against genetic perturbations and modulation of central carbon metabolism by the oxidative stress regulation
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53. Gene expression association study in feline mammary carcinomas
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54. A genome-wide screen for human salicylic acid (SA)-binding proteins reveals targets through which SA may influence development of various diseases
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55. Shmt2: A Stat3 Signaling New Player in Prostate Cancer Energy Metabolism
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56. Lectin PCL inhibits the Warburg effect of PC3 cells by combining with EGFR and inhibiting HK2
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57. Intersections of post-transcriptional gene regulatory mechanisms with intermediary metabolism
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58. Residual pyruvate kinase activity inPKLR-deficient erythroid precursors of a patient suffering from severe haemolytic anaemia
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59. Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis
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60. Pyruvate kinase M2 interacts with mammalian sterile 20-like kinase 1 and inhibits tamoxifen-induced apoptosis in human breast cancer cells
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61. The hexane fraction of the Moringa oleifera Lam seed extract induces apoptosis, causes cell cycle arrest, and modulates expression of HSP60, NPM, PGK1, RCN1, and PDIA1 in MCF7 cells
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62. Metabolic crosstalk in the breast cancer microenvironment
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63. Mst1/2 kinases restrain transformation in a novel transgenic model of Ras driven non-small cell lung cancer
    Kanchan Singh et al, 2019, Oncogene CrossRef
64. Nuclear localization of metabolic enzymes in immunity and metastasis
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66. Adaptive laboratory evolution of Corynebacterium glutamicum towards higher growth rates on glucose minimal medium
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67. Prognostic significance of metabolic enzyme pyruvate kinase M2 in breast cancer
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68. DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism
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70. Differential responses on energy metabolic pathway reprogramming between genotoxic and non-genotoxic hepatocarcinogens in rat liver cells
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71. A robust strategy for proteomic identification of biomarkers of invasive phenotype complexed with extracellular heat shock proteins
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72. Glycolysis promotes the progression of pancreatic cancer and reduces cancer cell sensitivity to gemcitabine
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73. Metabolic reprogramming by tobacco-specific nitrosamines (TSNAs) in cancer
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74. Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer
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75. The molecular mechanisms of LncRNA-correlated PKM2 in cancer metabolism.
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76. Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity
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77. Glycolysis regulated transglutaminase 2 activation in cardiopulmonary fibrogenic remodeling
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78. Serotonin activates glycolysis and mitochondria biogenesis in human breast cancer cells through activation of the Jak1/STAT3/ERK1/2 and adenylate cyclase/PKA, respectively
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79. Fragment-based drug discovery using cryo-EM
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80. An update review of deregulated tumor suppressive microRNAs and their contribution in various molecular subtypes of breast cancer
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82. OSU-A9 induced-reactive oxygen species cause cytotoxicity in duodenal and gastric cancer cells by decreasing phosphorylated nuclear pyruvate kinase M2 protein levels
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83. SNHG3 Functions as miRNA Sponge to Promote Breast Cancer Cells Growth Through the Metabolic Reprogramming
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84. Metabolic Symbiosis in Chemoresistance: Refocusing the Role of Aerobic Glycolysis.
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85. Identification of Parthenolide Dimers as Activators of Pyruvate Ki-nase M2 in Xenograft of Glioblastoma Multiforme in vivo
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86. Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis
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87. Inhibition of Anaplerosis Attenuated Vascular Proliferation in Pulmonary Arterial Hypertension
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88. The influence of photodynamic therapy on the Warburg effect in esophageal cancer cells
    Junqing Gan et al, 2020, Lasers Med Sci CrossRef
89. Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration.
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91. Key Signaling Pathways Engaged in Cancer Management: Current Update
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92. Cancer Glycolytic Dependence as a New Target of Olive Leaf Extract
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93. Metformin as an Adjuvant to Photodynamic Therapy in Resistant Basal Cell Carcinoma Cells
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94. Tannic Acid: Specific Form of Tannins in Cancer Chemoprevention and Therapy-Old and New Applications
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95. Friend turned Foe: A Curious Case of Disrupted Endosymbiotic Homeostasis Promoting the Warburg Effect in Sepsis
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96. Metabolic regulation of calcium pumps in pancreatic cancer: role of phosphofructokinase-fructose-bisphosphatase-3 (PFKFB3)
    D. A. Richardson et al, 2020, Cancer Metab CrossRef
97. Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy
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98. PKM2 ablation enhanced retinal function and survival in a preclinical model of retinitis pigmentosa
    Ethan Zhang et al, 2020, Mamm Genome CrossRef
99. Extracellular Vesicles isolated from Mesenchymal Stromal Cells Modulate CD4+ T Lymphocytes Toward a Regulatory Profile
    Flavia Franco da Cunha et al, 2020, Cells CrossRef
100. Aerobic Glycolysis in the Retina: Functional Roles of Pyruvate Kinase Isoforms
     Raju V. S. Rajala, 2020, Front. Cell Dev. Biol. CrossRef
101. Nuclear PKM2 promotes the progression of oral squamous cell carcinoma by inducing EMT and post-translationally repressing TGIF2
     Fumie Tanaka et al, 2018, Oncotarget CrossRef
102. PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose
     Sui Seng Tee et al, 2017, Oncotarget CrossRef
103. Role of pyruvate kinase M2-mediated metabolic reprogramming during podocyte differentiation
     Qi Yuan et al, 2020, Cell Death Dis CrossRef
104. Chemical simulation of hypoxia in donor cells improves development of somatic cell nuclear transfer‐derived embryos and increases abundance of transcripts related to glycolysis
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106. Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities
     Sejin Oh et al, 2020, Nat Commun CrossRef
107. Long non‑coding RNA BCYRN1 promotes glycolysis and tumor progression by regulating the miR‑149/PKM2 axis in non‑small‑cell lung cancer
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108. Pyruvate kinase type M2 contributes to the development of pancreatic ductal adenocarcinoma by regulating the production of metabolites and reactive oxygen species
     Misa Yokoyama et al, 2018, Int J Oncol CrossRef
109. PKM2 Expression as Biomarker for Resistance to Oxaliplatin-Based Chemotherapy in Colorectal Cancer
     Maria Sfakianaki et al, 2020, Cancers CrossRef
110. Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism
     Marek Samec et al, 2020, EPMA Journal CrossRef
111. Resisting Resistance to Immune Checkpoint Therapy: A Systematic Review
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112. Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back
     Lenka Koklesova et al, 2020, Cancers CrossRef
113. Phosphoproteomic analysis of dengue virus infected U937 cells and identification of pyruvate kinase M2 as a differentially phosphorylated phosphoprotein
     Jeerang Wongtrakul et al, 2020, Sci Rep CrossRef
114. Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses
     Jessica F Walls et al, 2020 CrossRef
115. The emerging role of long noncoding RNAs in normal liver function, disease and malignancy
     Amin Mahpour et al, 2020, JHEP Reports CrossRef
116. Role of tyrosine phosphorylation in modulating cancer cell metabolism
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117. Metabolic interventions: A new insight into the cancer immunotherapy
     Tao Yu et al, 2020, Archives of Biochemistry and Biophysics CrossRef
118. Disruption of microRNA-214 during general anaesthesia prevents brain injury and maintains mitochondrial fusion by promoting Mfn2 interaction with Pkm2.
     Tiejun Liu et al, 2020, J Cell Mol Med CrossRef
119. On the Origin of ATP Synthesis in Cancer
     Thomas N. Seyfried et al, 2020, iScience CrossRef
120. Single Mutation in the NFU1 Gene Metabolically Reprograms Pulmonary Artery Smooth Muscle Cells
     Joel James et al, 2020, ATVB CrossRef
121. SEMG1/2 augment energy metabolism of tumor cells
     Oleg Shuvalov et al, 2020, Cell Death Dis CrossRef
122. Alterations in the Transcriptional Programs of Myeloma Cells and the Microenvironment during Extramedullary Progression Affect Proliferation and Immune Evasion
     Daeun Ryu et al, 2020, Clin Cancer Res CrossRef
123. Novel Targeting of Transcription and Metabolism in Glioblastoma
     Yu-Ting Su et al, 2018, Clin Cancer Res CrossRef
124. Flavonoids Targeting HIF-1: Implications on Cancer Metabolism.
     Marek Samec et al, 2021, Cancers (Basel) CrossRef
125. Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers
     Xiangyu Li et al, 2021, Cancers CrossRef
126. The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs.
     Dexter L Puckett et al, 2021, Int J Mol Sci CrossRef
127. Phytochemicals Block Glucose Utilization and Lipid Synthesis to Counteract Metabolic Reprogramming in Cancer Cells
     Qiong Wu et al, 2021, Applied Sciences CrossRef
128. Therapeutic Status and Available Strategies in Pancreatic Ductal Adenocarcinoma
     Gitika Thakur et al, 2021, Biomedicines CrossRef
129. Identify the effect of As(III) on the structural stability of monomeric PKM2 and its carcinogenicity: A molecular dynamics and QM/MM based approach
     Priyani Paligaspe et al, 2021, Journal of Molecular Structure CrossRef
130. The Importance of Mitochondrial Pyruvate Carrier in Cancer Cell Metabolism and Tumorigenesis
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131. The Hallmarks of Flavonoids in Cancer
     Luis Gustavo Saboia Ponte et al, 2021, Molecules CrossRef
132. Role of protein S-Glutathionylation in cancer progression and development of resistance to anti-cancer drugs
     Debojyoti Pal et al, 2021, Archives of Biochemistry and Biophysics CrossRef
133. HnRNPA1 ISOFORM BRING DIVERSITY IN GLIOMA CELL SURVIVAL
     Vidhi Vashistha et al, 2021 CrossRef
134. The role of the HIF‐1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer
     Jing‐Zi Wang et al, 2021, Cancer Communications CrossRef
135. The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model
     Alessandro Matte et al, 2021 CrossRef
136. Tumor pyruvate kinase M2 modulators: a comprehensive account of activators and inhibitors as anticancer agents
     Bhagyashri Rathod et al, 2021, RSC Med. Chem. CrossRef
137. Reactive Astrocytes: Critical Players in the Development of Chronic Pain
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138. Metabolic changes in triple negative breast cancer-focus on aerobic glycolysis.
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139. The effect of autocrine motility factor alone and in combination with methyl jasmonate on liver cancer cell growth
     Nam Ho Jeoung et al, 2021 CrossRef
140. Targeting pyruvate kinase muscle isoform 2 (PKM2) in cancer: What do we know so far?
     Abu Sufiyan Chhipa et al, 2021, Life Sciences CrossRef
141. Phytocompounds Targeting Metabolic Reprogramming in Cancer: An Assessment of Role, Mechanisms, Pathways, and Therapeutic Relevance
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143. Serine hydroxymethyltransferase 2: a novel target for human cancer therapy
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144. PKM2 Regulates HSP90-Mediated Stability of the IGF-1R Precursor Protein and Promotes Cancer Cell Survival during Hypoxia
     Han Koo et al, 2021, Cancers CrossRef
145. Base editing‐mediated perturbation of endogenous PKM1/2 splicing facilitates isoform‐specific functional analysis in vitro and in vivo
     Jianxiang Lin et al, 2021, Cell Prolif CrossRef
146. Cancer cells change their glucose metabolism to overcome increased ROS: One step from cancer cell to cancer stem cell?
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147. Extracellular PKM2 facilitates organ-tissue fibrosis progression
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148. Cdc25A inhibits autophagy-mediated ferroptosis by upregulating ErbB2 through PKM2 dephosphorylation in cervical cancer cells
     Chen Wang et al, 2021, Cell Death Dis CrossRef
149. Silencing of Pyruvate Kinase M2 via a Metal–Organic Framework Based Theranostic Gene Nanomedicine for Triple-Negative Breast Cancer Therapy
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150. A Clinical PET Imaging Tracer ([¹⁸F]DASA-23) to Monitor Pyruvate Kinase M2-Induced Glycolytic Reprogramming in Glioblastoma.
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151. Extracellular Vesicles Induce an Aggressive Phenotype in Luminal Breast Cancer Cells Via PKM2 Phosphorylation
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152. Ketogenic diet and cancer: Fad or fabulous?
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153. Interactions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis.
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154. Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer
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155. Translocalization of enhanced PKM2 protein into the nucleus induced by cancer upregulated gene 2 confers cancer stem cell-like phenotypes
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156. Curcumae Radix Decreases Neurodegenerative Markers through Glycolysis Decrease and TCA Cycle Activation
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157. The Role of PKM2 in Diabetic Microangiopathy
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158. The CXCL12/CXCR4/ACKR3 Signaling Axis Regulates PKM2 and Glycolysis
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159. The RAGE/multiligand axis: a new actor in tumor biology
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160. Application Value of TuM2-PK Detection in Gastrointestinal Tumors
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161. The C-Terminal Acidic Tail Modulates the Anticancer Properties of HMGB1
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162. Relationship between metabolic reprogramming and drug resistance in breast cancer
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163. Proteomic Analysis of Tumor-specific Biomarkers in Colon Cancer
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164. TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure
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165. Knowledge-driven design and optimization of potent symmetric anticancer molecules: A case study on PKM2 activators
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166. MNX1-AS1, a c-Myc induced lncRNA, promotes the Warburg effect by regulating PKM2 nuclear translocation
     Yang Wu et al, 2022, J Exp Clin Cancer Res CrossRef
167. Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development
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168. Role of Moonlighting Proteins in Disease: Analyzing the Contribution of Canonical and Moonlighting Functions in Disease Progression
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169. PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism
     Hongyan Lin et al, 2023, European Journal of Medicinal Chemistry CrossRef
170. HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway
     Jiancheng Lv et al, 2023, J Exp Clin Cancer Res CrossRef
171. Panax notoginseng saponins (PNS) attenuate Th17 cell differentiation in CIA mice via inhibition of nuclear PKM2-mediated STAT3 phosphorylation
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172. Role of tumor microenvironment in cancer progression and therapeutic strategy
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173. Histone deacetylase inhibitors synergize with sildenafil to suppress purine metabolism and proliferation in pulmonary hypertension
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174. Applications and prospects of cryo-EM in drug discovery
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175. Design, Synthesis and Biological Evaluation of Quinoline-8-Sulfonamides as Inhibitors of the Tumor Cell-Specific M2 Isoform of Pyruvate Kinase: Preliminary Study
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176. Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling
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177. Anti‐Warburg effect via generation of ROS and inhibition of PKM2 /β‐catenin mediates apoptosis of lambertianic acid in prostate cancer cells
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178. The essential molecular requirements for the transformation of normal cells into established cancer cells, with implications for a novel anti‐cancer agent
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179. Activation of pyruvate kinase as therapeutic option for rare hemolytic anemias: Shedding new light on an old enzyme
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180. Knockdown of pyruvate kinase M2 suppresses bladder cancer progression
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181. Design, synthesis and biological evaluation of novel modified dual-target shikonin derivatives for colorectal cancer treatment
     Yudi Ma et al, 2023, Bioorganic Chemistry CrossRef
182. Glycolysis as key regulatory step in FSH-induced rat Sertoli cell proliferation: Role of the mTORC1 pathway
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183. KITENIN promotes aerobic glycolysis through PKM2 induction by upregulating the c-Myc/hnRNPs axis in colorectal cancer
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185. Antiviral epithelial-macrophage crosstalk permits secondary bacterial infections
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186. Breast Cancer Chemoresistance: Insights into the Regulatory Role of lncRNA
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