1. Succinyl-5-aminoimidazole-4-carboxamide-1-ribose 5′-Phosphate (SAICAR) Activates Pyruvate Kinase Isoform M2 (PKM2) in Its Dimeric Form
    Ming Yan et al, 2016, Biochemistry CrossRef
  2. Santamarine Inhibits NF-κB Activation and Induces Mitochondrial Apoptosis in A549 Lung Adenocarcinoma Cells via Oxidative Stress
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  3. Collateral Damage Intended—Cancer-Associated Fibroblasts and Vasculature Are Potential Targets in Cancer Therapy
    Ana Cavaco et al, 2017, IJMS CrossRef
  4. IGF-1-mediated PKM2/β-catenin/miR-152 regulatory circuit in breast cancer
    Yi-Yang Wen et al, 2017, Sci Rep CrossRef
  5. Structural Investigation of a Dimeric Variant of Pyruvate Kinase Muscle Isoform 2
    Dhiraj Srivastava et al, 2017, Biochemistry CrossRef
  6. Oncogene-Driven Metabolic Alterations in Cancer
    Hye-Young Min et al, 2018, Biomolecules & Therapeutics CrossRef
  7. FFJ-3 inhibits PKM2 protein expression via the PI3K/Akt signaling pathway and activates the mitochondrial apoptosis signaling pathway in human cancer cells
    Dengyun Li et al, 2017 CrossRef
  8. Pulmonary Hypertension Associated With Scleroderma and Connective Tissue Disease: Potential Molecular and Cellular Targets
    Maria Trojanowska, 2017, Advances in Pulmonary Hypertension CrossRef
  9. Metabolic phenotyping of CHO cells varying in cellular biomass accumulation and maintenance during fed-batch culture
    Alejandro Fernandez-Martell et al, 2018, Biotechnol. Bioeng. CrossRef
  10. AKT2 contributes to increase ovarian cancer cell migration and invasion through the AKT2-PKM2-STAT3/NF-κB axis
    Bin Zheng et al, 2018, Cellular Signalling CrossRef
  11. GLP2 Promotes Directed Differentiation from Osteosarcoma Cells to Osteoblasts and Inhibits Growth of Osteosarcoma Cells
    Yi Lu et al, 2018, Molecular Therapy - Nucleic Acids CrossRef
  12. Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting β-catenin by activating PKM2 and inactivating PTEN
    Qidi Zheng et al, 2018, Cell Death Dis CrossRef
  13. Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling
    Ming-Chuan Hsu et al, 2018, Mol Cancer CrossRef
  14. Hepatic glucose-6-phosphatase-α deficiency leads to metabolic reprogramming in glycogen storage disease type Ia
    Jun-Ho Cho et al, 2018, Biochemical and Biophysical Research Communications CrossRef
  15. Metabolic Reprogramming in Thyroid Carcinoma
    Raquel Guimaraes Coelho et al, 2018, Front. Oncol. CrossRef
  16. The Warburg Effect in Diabetic Kidney Disease
    Guanshi Zhang et al, 2018, Seminars in Nephrology CrossRef
  17. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways
    Marteinn T Snaebjornsson et al, 2018, Exp Mol Med CrossRef
  18. The Warburg effect and glucose-derived cancer theranostics
    Rakesh K. Tekade et al, 2017, Drug Discovery Today CrossRef
  19. Including the mitochondrial metabolism of l-lactate in cancer metabolic reprogramming
    Lidia de Bari et al, 2018, Cell. Mol. Life Sci. CrossRef
  20. Enzyme targeting strategies for prevention and treatment of cancer: Implications for cancer therapy.
    Mohammad Hassan Baig et al, 2019, Semin Cancer Biol CrossRef
  21. Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities After Ischemic Stroke in Adult Mice
    Dongdong Chen et al, 2018, Neurotherapeutics CrossRef
  22. A Novel Multiple-Read Screen for Metabolically Active Compounds Based on a Genetically Encoded FRET Sensor for ATP
    Ziyan Zhao et al, 2018, SLAS DISCOVERY: Advancing Life Sciences R&D CrossRef
  23. Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer
    Bo-wen Liu et al, 2018, Acta Pharmacol Sin CrossRef
  24. Hidden features: exploring the non-canonical functions of metabolic enzymes
    Peiwei Huangyang et al, 2018, Dis. Model. Mech. CrossRef
  25. Constitutive androstane receptor activation evokes the expression of glycolytic genes
    Andrei A. Yarushkin et al, 2016, Biochemical and Biophysical Research Communications CrossRef
  26. Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming
    Angelo D'Alessandro et al, 2018, Antioxidants & Redox Signaling CrossRef
  27. Emerging roles of Myc in stem cell biology and novel tumor therapies.
    Go J Yoshida, 2018, J Exp Clin Cancer Res CrossRef
  28. Mechanisms contributing to persistently activated cell phenotypes in pulmonary hypertension
    Cheng-Jun Hu et al, 2018, J Physiol CrossRef
  29. In Vitro Modulation of Redox and Metabolism Interplay at the Brain Vascular Endothelium: Genomic and Proteomic Profiles of Sulforaphane Activity
    Ravi K. Sajja et al, 2018, Sci Rep CrossRef
  30. Environmentally relevant concentrations of carbamazepine induce liver histopathological changes and a gender-specific response in hepatic proteome of Chinese rare minnows (Gobiocypris rarus)
    Saihong Yan et al, 2018, Environmental Pollution CrossRef
  31. An Update on Patents Covering Agents That Interfere with the Cancer Glycolytic Cascade
    Serena Fortunato et al, 2018, ChemMedChem CrossRef
  32. Colorectal Cancer and Metabolism
    Rachel E. Brown et al, 2018, Curr Colorectal Cancer Rep CrossRef
  33. Identification of Protein Abundance Changes in Hepatocellular Carcinoma Tissues Using PCT-SWATH
    Yi Zhu et al, 2018, Prot. Clin. Appl. CrossRef
  34. miR-625-5p/PKM2 negatively regulates melanoma glycolysis state
    Hailin Zhang et al, 2018, J Cell Biochem CrossRef
  35. The reduced activity of PP-1α under redox stress condition is a consequence of GSH-mediated transient disulfide formation
    Simranjit Singh et al, 2018, Sci Rep CrossRef
  36. Human asparagine synthetase associates with the mitotic spindle
    Chalongrat Noree et al, 2018, Biology Open CrossRef
  37. Non-canonical localization of PKM2 in cancer progression: Mechanism of nuclear translocation
    Sajid Amin et al, 2019, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer CrossRef
  38. Overexpression of Pyruvate Kinase M2 in Tumor Tissues Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma
    Rui Zhao et al, 2019, Pathol. Oncol. Res. CrossRef
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  40. Glucagon-Induced Acetylation of Energy-Sensing Factors in Control of Hepatic Metabolism
    Li Zhang et al, 2019, IJMS CrossRef
  41. A New Compound-ensemble Strategy for Validating Cancer Drug Targets Confirms that Inhibiting Glycolysis Blocks Leukemic Cell Proliferation.
    Ziyan Zhao et al, 2018, SSRN Journal CrossRef
  42. Breaking Glucose Transporter 1/Pyruvate Kinase M2 Glycolytic Loop Is Required for Cantharidin Inhibition of Metastasis in Highly Metastatic Breast Cancer
    Yanhong Pan et al, 2019, Front. Pharmacol. CrossRef
  43. Evolutionary engineering of Corynebacterium glutamicum
    Roberto G. Stella et al, 2019, Biotechnol. J. CrossRef
  44. Enhanced penetration and cytotoxicity of metformin and collagenase conjugated gold nanoparticles in breast cancer spheroids
    Elaheh Dalir Abdolahinia et al, 2019, Life Sciences CrossRef
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    Manohar Bhat et al, 2019 CrossRef
  46. PKM2, function and expression and regulation
    Ze Zhang et al, 2019, Cell Biosci CrossRef
  47. FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis.
    Alex Cordero et al, 2019, Oncogene CrossRef
  48. Beta‐elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation
    Yanhong Pan et al, 2019, J Cell Mol Med CrossRef
  49. Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism
    Yannick Audet-Delage et al, 2017, Mol Pharmacol CrossRef
  50. Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2
    Dhiraj Srivastava et al, 2019, Biochemistry CrossRef
  51. Metabolic Plasticity of Acute Myeloid Leukemia
    null Kreitz et al, 2019, Cells CrossRef
  52. Redox rebalance against genetic perturbations and modulation of central carbon metabolism by the oxidative stress regulation
    Kazuyuki Shimizu et al, 2019, Biotechnology Advances CrossRef
  53. Gene expression association study in feline mammary carcinomas
    Daniela Ferreira et al, 2019, PLoS ONE CrossRef
  54. A genome-wide screen for human salicylic acid (SA)-binding proteins reveals targets through which SA may influence development of various diseases
    Hyong Woo Choi et al, 2019, Sci Rep CrossRef
  55. Shmt2: A Stat3 Signaling New Player in Prostate Cancer Energy Metabolism
    null Marrocco et al, 2019, Cells CrossRef
  56. Lectin PCL inhibits the Warburg effect of PC3 cells by combining with EGFR and inhibiting HK2
    Hong Zhang et al, 2017 CrossRef
  57. Intersections of post-transcriptional gene regulatory mechanisms with intermediary metabolism
    Waqar Arif et al, 2017, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms CrossRef
  58. Residual pyruvate kinase activity inPKLR-deficient erythroid precursors of a patient suffering from severe haemolytic anaemia
    Thomas R.L. Klei et al, 2017, Eur J Haematol CrossRef
  59. Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis
    Jinlu Dai et al, 2019, J. Exp. Med. CrossRef
  60. Pyruvate kinase M2 interacts with mammalian sterile 20-like kinase 1 and inhibits tamoxifen-induced apoptosis in human breast cancer cells
    Feihu Ji et al, 2017, Tumour Biol. CrossRef
  61. The hexane fraction of the Moringa oleifera Lam seed extract induces apoptosis, causes cell cycle arrest, and modulates expression of HSP60, NPM, PGK1, RCN1, and PDIA1 in MCF7 cells
    I.A. Adebayo et al, 2019, South African Journal of Botany CrossRef
  62. Metabolic crosstalk in the breast cancer microenvironment
    Ana S. Dias et al, 2019, European Journal of Cancer CrossRef
  63. Mst1/2 kinases restrain transformation in a novel transgenic model of Ras driven non-small cell lung cancer
    Kanchan Singh et al, 2019, Oncogene CrossRef
  64. Nuclear localization of metabolic enzymes in immunity and metastasis
    Yuchen He et al, 2017, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer CrossRef
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    Lydie Plecitá-Hlavatá et al, 2017 CrossRef
  66. Adaptive laboratory evolution of Corynebacterium glutamicum towards higher growth rates on glucose minimal medium
    Eugen Pfeifer et al, 2017, Sci Rep CrossRef
  67. Prognostic significance of metabolic enzyme pyruvate kinase M2 in breast cancer
    Yiming Yang et al, 2017, Medicine CrossRef
  68. DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism
    Ling Chen et al, 2019, Epigenetics & Chromatin CrossRef
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  70. Differential responses on energy metabolic pathway reprogramming between genotoxic and non-genotoxic hepatocarcinogens in rat liver cells
    Yuko Ito et al, 2019, J Toxicol Pathol CrossRef
  71. A robust strategy for proteomic identification of biomarkers of invasive phenotype complexed with extracellular heat shock proteins
    Steven G. Griffiths et al, 2019, Cell Stress and Chaperones CrossRef
  72. Glycolysis promotes the progression of pancreatic cancer and reduces cancer cell sensitivity to gemcitabine
    Shangnan Dai et al, 2020, Biomedicine & Pharmacotherapy CrossRef
  73. Metabolic reprogramming by tobacco-specific nitrosamines (TSNAs) in cancer
    Saharnaz Sarlak et al, 2019, Seminars in Cell & Developmental Biology CrossRef
  74. Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer
    Sehui Kim et al, 2019, J Exp Clin Cancer Res CrossRef
  75. The molecular mechanisms of LncRNA-correlated PKM2 in cancer metabolism.
    Ting Tao et al, 2019, Biosci Rep CrossRef
  76. Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity
    Stefano Angiari et al, 2019, Cell Metabolism CrossRef
  77. Glycolysis regulated transglutaminase 2 activation in cardiopulmonary fibrogenic remodeling
    Chinmayee D. Bhedi et al, 2019, FASEB j. CrossRef
  78. Serotonin activates glycolysis and mitochondria biogenesis in human breast cancer cells through activation of the Jak1/STAT3/ERK1/2 and adenylate cyclase/PKA, respectively
    Mauro Sola-Penna et al, 2019, Br J Cancer CrossRef
  79. Fragment-based drug discovery using cryo-EM
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  80. An update review of deregulated tumor suppressive microRNAs and their contribution in various molecular subtypes of breast cancer
    Narges Dastmalchi et al, 2019, Gene CrossRef
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    Chenchu Lin et al, 2019 CrossRef
  82. OSU-A9 induced-reactive oxygen species cause cytotoxicity in duodenal and gastric cancer cells by decreasing phosphorylated nuclear pyruvate kinase M2 protein levels
    Chang-Fang Chiu et al, 2020, Biochemical Pharmacology CrossRef
  83. SNHG3 Functions as miRNA Sponge to Promote Breast Cancer Cells Growth Through the Metabolic Reprogramming
    Yan Li et al, 2020, Appl Biochem Biotechnol CrossRef
  84. Metabolic Symbiosis in Chemoresistance: Refocusing the Role of Aerobic Glycolysis.
    Lisi Ma et al, 2020, Front Oncol CrossRef
  85. Identification of Parthenolide Dimers as Activators of Pyruvate Ki-nase M2 in Xenograft of Glioblastoma Multiforme in vivo
    Yahui Ding et al, 2020, J. Med. Chem. CrossRef
  86. Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis
    Jiao Feng et al, 2020, J Exp Clin Cancer Res CrossRef
  87. Inhibition of Anaplerosis Attenuated Vascular Proliferation in Pulmonary Arterial Hypertension
    Mathews Valuparampil Varghese et al, 2020, JCM CrossRef
  88. The influence of photodynamic therapy on the Warburg effect in esophageal cancer cells
    Junqing Gan et al, 2020, Lasers Med Sci CrossRef
  89. Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration.
    Ajit Magadum et al, 2020, Circulation CrossRef
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  91. Key Signaling Pathways Engaged in Cancer Management: Current Update
    Sanjiv Singh et al, 2020, CCTR CrossRef
  92. Cancer Glycolytic Dependence as a New Target of Olive Leaf Extract
    Jessica Ruzzolini et al, 2020, Cancers CrossRef
  93. Metformin as an Adjuvant to Photodynamic Therapy in Resistant Basal Cell Carcinoma Cells
    Marta Mascaraque et al, 2020, Cancers CrossRef
  94. Tannic Acid: Specific Form of Tannins in Cancer Chemoprevention and Therapy-Old and New Applications
    Wanda Baer-Dubowska et al, 2020, Curr Pharmacol Rep CrossRef
  95. Friend turned Foe: A Curious Case of Disrupted Endosymbiotic Homeostasis Promoting the Warburg Effect in Sepsis
    Natesan Vasanthakumar et al, 2020, Medical Hypotheses CrossRef
  96. Metabolic regulation of calcium pumps in pancreatic cancer: role of phosphofructokinase-fructose-bisphosphatase-3 (PFKFB3)
    D. A. Richardson et al, 2020, Cancer Metab CrossRef
  97. Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy
    Michael F. Coleman et al, 2020, Cancers CrossRef
  98. PKM2 ablation enhanced retinal function and survival in a preclinical model of retinitis pigmentosa
    Ethan Zhang et al, 2020, Mamm Genome CrossRef
  99. Extracellular Vesicles isolated from Mesenchymal Stromal Cells Modulate CD4+ T Lymphocytes Toward a Regulatory Profile
    Flavia Franco da Cunha et al, 2020, Cells CrossRef
  100. Aerobic Glycolysis in the Retina: Functional Roles of Pyruvate Kinase Isoforms
    Raju V. S. Rajala, 2020, Front. Cell Dev. Biol. CrossRef
  101. Nuclear PKM2 promotes the progression of oral squamous cell carcinoma by inducing EMT and post-translationally repressing TGIF2
    Fumie Tanaka et al, 2018, Oncotarget CrossRef
  102. PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose
    Sui Seng Tee et al, 2017, Oncotarget CrossRef
  103. Role of pyruvate kinase M2-mediated metabolic reprogramming during podocyte differentiation
    Qi Yuan et al, 2020, Cell Death Dis CrossRef
  104. Chemical simulation of hypoxia in donor cells improves development of somatic cell nuclear transfer‐derived embryos and increases abundance of transcripts related to glycolysis
    Raissa F. Cecil et al, 2020, Mol Reprod Dev CrossRef
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  106. Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities
    Sejin Oh et al, 2020, Nat Commun CrossRef
  107. Long non‑coding RNA BCYRN1 promotes glycolysis and tumor progression by regulating the miR‑149/PKM2 axis in non‑small‑cell lung cancer
    Ning Lang et al, 2020, Mol Med Report CrossRef
  108. Pyruvate kinase type M2 contributes to the development of pancreatic ductal adenocarcinoma by regulating the production of metabolites and reactive oxygen species
    Misa Yokoyama et al, 2018, Int J Oncol CrossRef
  109. PKM2 Expression as Biomarker for Resistance to Oxaliplatin-Based Chemotherapy in Colorectal Cancer
    Maria Sfakianaki et al, 2020, Cancers CrossRef
  110. Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism
    Marek Samec et al, 2020, EPMA Journal CrossRef
  111. Resisting Resistance to Immune Checkpoint Therapy: A Systematic Review
    Yolla Haibe et al, 2020, IJMS CrossRef
  112. Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back
    Lenka Koklesova et al, 2020, Cancers CrossRef
  113. Phosphoproteomic analysis of dengue virus infected U937 cells and identification of pyruvate kinase M2 as a differentially phosphorylated phosphoprotein
    Jeerang Wongtrakul et al, 2020, Sci Rep CrossRef
  114. Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses
    Jessica F Walls et al, 2020 CrossRef
  115. The emerging role of long noncoding RNAs in normal liver function, disease and malignancy
    Amin Mahpour et al, 2020, JHEP Reports CrossRef
  116. Role of tyrosine phosphorylation in modulating cancer cell metabolism
    Maria Letizia Taddei et al, 2020, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer CrossRef
  117. Metabolic interventions: A new insight into the cancer immunotherapy
    Tao Yu et al, 2020, Archives of Biochemistry and Biophysics CrossRef
  118. Disruption of microRNA-214 during general anaesthesia prevents brain injury and maintains mitochondrial fusion by promoting Mfn2 interaction with Pkm2.
    Tiejun Liu et al, 2020, J Cell Mol Med CrossRef
  119. On the Origin of ATP Synthesis in Cancer
    Thomas N. Seyfried et al, 2020, iScience CrossRef
  120. Single Mutation in the NFU1 Gene Metabolically Reprograms Pulmonary Artery Smooth Muscle Cells
    Joel James et al, 2020, ATVB CrossRef
  121. SEMG1/2 augment energy metabolism of tumor cells
    Oleg Shuvalov et al, 2020, Cell Death Dis CrossRef
  122. Alterations in the Transcriptional Programs of Myeloma Cells and the Microenvironment during Extramedullary Progression Affect Proliferation and Immune Evasion
    Daeun Ryu et al, 2020, Clin Cancer Res CrossRef
  123. Novel Targeting of Transcription and Metabolism in Glioblastoma
    Yu-Ting Su et al, 2018, Clin Cancer Res CrossRef
  124. Flavonoids Targeting HIF-1: Implications on Cancer Metabolism.
    Marek Samec et al, 2021, Cancers (Basel) CrossRef
  125. Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers
    Xiangyu Li et al, 2021, Cancers CrossRef
  126. The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs.
    Dexter L Puckett et al, 2021, Int J Mol Sci CrossRef
  127. Phytochemicals Block Glucose Utilization and Lipid Synthesis to Counteract Metabolic Reprogramming in Cancer Cells
    Qiong Wu et al, 2021, Applied Sciences CrossRef
  128. Therapeutic Status and Available Strategies in Pancreatic Ductal Adenocarcinoma
    Gitika Thakur et al, 2021, Biomedicines CrossRef
  129. Identify the effect of As(III) on the structural stability of monomeric PKM2 and its carcinogenicity: A molecular dynamics and QM/MM based approach
    Priyani Paligaspe et al, 2021, Journal of Molecular Structure CrossRef
  130. The Importance of Mitochondrial Pyruvate Carrier in Cancer Cell Metabolism and Tumorigenesis
    Ainhoa Ruiz-Iglesias et al, 2021, Cancers CrossRef
  131. The Hallmarks of Flavonoids in Cancer
    Luis Gustavo Saboia Ponte et al, 2021, Molecules CrossRef
  132. Role of protein S-Glutathionylation in cancer progression and development of resistance to anti-cancer drugs
    Debojyoti Pal et al, 2021, Archives of Biochemistry and Biophysics CrossRef
    Vidhi Vashistha et al, 2021 CrossRef
  134. The role of the HIF‐1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer
    Jing‐Zi Wang et al, 2021, Cancer Communications CrossRef
  135. The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model
    Alessandro Matte et al, 2021 CrossRef
  136. Tumor pyruvate kinase M2 modulators: a comprehensive account of activators and inhibitors as anticancer agents
    Bhagyashri Rathod et al, 2021, RSC Med. Chem. CrossRef
  137. Reactive Astrocytes: Critical Players in the Development of Chronic Pain
    James Tang et al, 2021, Front. Psychiatry CrossRef
  138. Metabolic changes in triple negative breast cancer-focus on aerobic glycolysis.
    J R Dev Arundhathi et al, 2021, Mol Biol Rep CrossRef
  139. The effect of autocrine motility factor alone and in combination with methyl jasmonate on liver cancer cell growth
    Nam Ho Jeoung et al, 2021 CrossRef
  140. Targeting pyruvate kinase muscle isoform 2 (PKM2) in cancer: What do we know so far?
    Abu Sufiyan Chhipa et al, 2021, Life Sciences CrossRef
  141. Phytocompounds Targeting Metabolic Reprogramming in Cancer: An Assessment of Role, Mechanisms, Pathways, and Therapeutic Relevance
    Asifa Khan et al, 2021, J. Agric. Food Chem. CrossRef
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  143. Serine hydroxymethyltransferase 2: a novel target for human cancer therapy
    Min Xie et al, 2021, Invest New Drugs CrossRef
  144. PKM2 Regulates HSP90-Mediated Stability of the IGF-1R Precursor Protein and Promotes Cancer Cell Survival during Hypoxia
    Han Koo et al, 2021, Cancers CrossRef
  145. Base editing‐mediated perturbation of endogenous PKM1/2 splicing facilitates isoform‐specific functional analysis in vitro and in vivo
    Jianxiang Lin et al, 2021, Cell Prolif CrossRef
  146. Cancer cells change their glucose metabolism to overcome increased ROS: One step from cancer cell to cancer stem cell?
    Zahra Ghanbari Movahed et al, 2019, Biomedicine & Pharmacotherapy CrossRef
  147. Extracellular PKM2 facilitates organ-tissue fibrosis progression
    Hongwei Han et al, 2021, iScience CrossRef
  148. Cdc25A inhibits autophagy-mediated ferroptosis by upregulating ErbB2 through PKM2 dephosphorylation in cervical cancer cells
    Chen Wang et al, 2021, Cell Death Dis CrossRef
  149. Silencing of Pyruvate Kinase M2 via a Metal–Organic Framework Based Theranostic Gene Nanomedicine for Triple-Negative Breast Cancer Therapy
    Siming Huang et al, 2021, ACS Appl. Mater. Interfaces CrossRef
  150. A Clinical PET Imaging Tracer ([18F]DASA-23) to Monitor Pyruvate Kinase M2-Induced Glycolytic Reprogramming in Glioblastoma.
    Corinne Beinat et al, 2021, Clin Cancer Res CrossRef
  151. Extracellular Vesicles Induce an Aggressive Phenotype in Luminal Breast Cancer Cells Via PKM2 Phosphorylation
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  152. Ketogenic diet and cancer: Fad or fabulous?
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  153. Interactions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis.
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  154. Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer
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  155. Translocalization of enhanced PKM2 protein into the nucleus induced by cancer upregulated gene 2 confers cancer stem cell-like phenotypes
    Natpaphan Yawut et al, 2022, BMB Rep CrossRef
  156. Curcumae Radix Decreases Neurodegenerative Markers through Glycolysis Decrease and TCA Cycle Activation
    Seong-Lae Jo et al, 2022, Nutrients CrossRef
  157. The Role of PKM2 in Diabetic Microangiopathy
    Chao Tu et al, 2022, DMSO CrossRef
  158. The CXCL12/CXCR4/ACKR3 Signaling Axis Regulates PKM2 and Glycolysis
    Kathryn E. Luker et al, 2022, Cells CrossRef
  159. The RAGE/multiligand axis: a new actor in tumor biology
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  160. Application Value of TuM2-PK Detection in Gastrointestinal Tumors
    发蓉 刘, 2022, ACM CrossRef
  161. The C-Terminal Acidic Tail Modulates the Anticancer Properties of HMGB1
    Chloé Borde et al, 2022, IJMS CrossRef
  162. Relationship between metabolic reprogramming and drug resistance in breast cancer
    Linlin Lv et al, 2022, Front. Oncol. CrossRef
  163. Proteomic Analysis of Tumor-specific Biomarkers in Colon Cancer
    Yu-An Chien et al, 2022, CP CrossRef
  164. TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure
    Maria Areli Lorenzana-Carrillo et al, 2022, Sci. Transl. Med. CrossRef
  165. Knowledge-driven design and optimization of potent symmetric anticancer molecules: A case study on PKM2 activators
    Eshika Jaiswal et al, 2022, Computers in Biology and Medicine CrossRef
  166. MNX1-AS1, a c-Myc induced lncRNA, promotes the Warburg effect by regulating PKM2 nuclear translocation
    Yang Wu et al, 2022, J Exp Clin Cancer Res CrossRef
  167. Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development
    Lixia Gao et al, 2023, J Exp Clin Cancer Res CrossRef
  168. Role of Moonlighting Proteins in Disease: Analyzing the Contribution of Canonical and Moonlighting Functions in Disease Progression
    Mario Huerta et al, 2023, Cells CrossRef
  169. PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism
    Hongyan Lin et al, 2023, European Journal of Medicinal Chemistry CrossRef
  170. HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway
    Jiancheng Lv et al, 2023, J Exp Clin Cancer Res CrossRef
  171. Panax notoginseng saponins (PNS) attenuate Th17 cell differentiation in CIA mice via inhibition of nuclear PKM2-mediated STAT3 phosphorylation
    Mei-Yu Shen et al, 2023, Pharmaceutical Biology CrossRef
  172. Role of tumor microenvironment in cancer progression and therapeutic strategy
    Qingjing Wang et al, 2023, Cancer Medicine CrossRef
  173. Histone deacetylase inhibitors synergize with sildenafil to suppress purine metabolism and proliferation in pulmonary hypertension
    Hui Zhang et al, 2023, Vascular Pharmacology CrossRef
  174. Applications and prospects of cryo-EM in drug discovery
    Kong-Fu Zhu et al, 2023, Military Med Res CrossRef
  175. Design, Synthesis and Biological Evaluation of Quinoline-8-Sulfonamides as Inhibitors of the Tumor Cell-Specific M2 Isoform of Pyruvate Kinase: Preliminary Study
    Krzysztof Marciniec et al, 2023, Molecules CrossRef
  176. Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling
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  177. Anti‐Warburg effect via generation of ROS and inhibition of PKM2 /β‐catenin mediates apoptosis of lambertianic acid in prostate cancer cells
    Ji‐Na Pak et al, 2023, Phytotherapy Research CrossRef
  178. The essential molecular requirements for the transformation of normal cells into established cancer cells, with implications for a novel anti‐cancer agent
    Hilmar M. Warenius, 2023, Cancer Reports CrossRef
  179. Activation of pyruvate kinase as therapeutic option for rare hemolytic anemias: Shedding new light on an old enzyme
    Myrthe J. van Dijk et al, 2023, Blood Reviews CrossRef
  180. Knockdown of pyruvate kinase M2 suppresses bladder cancer progression
    Guang-Cheng Luo et al, 2023 CrossRef
  181. Design, synthesis and biological evaluation of novel modified dual-target shikonin derivatives for colorectal cancer treatment
    Yudi Ma et al, 2023, Bioorganic Chemistry CrossRef
  182. Glycolysis as key regulatory step in FSH-induced rat Sertoli cell proliferation: Role of the mTORC1 pathway
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