1. microRNA-874 suppresses tumor proliferation and metastasis in hepatocellular carcinoma by targeting the DOR/EGFR/ERK pathway
    Yi Zhang et al, 2018, Cell Death Dis CrossRef
  2. RAS-mediated oncogenic signaling pathways in human malignancies
    Abdul Q. Khan et al, 2018, Seminars in Cancer Biology CrossRef
  3. The role of enhancer of zeste homolog 2: From viral epigenetics to the carcinogenesis of hepatocellular carcinoma
    Luca Sanna et al, 2018, J Cell Physiol CrossRef
  4. STIP1 is over-expressed in hepatocellular carcinoma and promotes the growth and migration of cancer cells
    Xiaoling Luo et al, 2018, Gene CrossRef
  5. Role of the ERK1/2 Signaling Pathway in the Replication of Junín and Tacaribe Viruses
    Jesús Brunetti et al, 2018, Viruses CrossRef
  6. Capicua suppresses hepatocellular carcinoma progression by controlling the ETV4-MMP1 axis
    Eunjeong Kim et al, 2018, Hepatology CrossRef
  7. Identification of inhibitors synergizing gemcitabine sensitivity in the squamous subtype of pancreatic ductal adenocarcinoma (PDAC)
    Jia Lin Er et al, 2018, Apoptosis CrossRef
  8. Insights into the etiology-associated gene regulatory networks in hepatocellular carcinoma from The Cancer Genome Atlas
    Veerabrahma Pratap Seshachalam et al, 2018, Journal of Gastroenterology and Hepatology CrossRef
  9. An ethyl acetate fraction of Artemisia capillaris (ACE-63) induced apoptosis and anti-angiogenesis via inhibition of PI3K/AKT signaling in hepatocellular carcinoma
    Kyung Hee Jung et al, 2018, Phytotherapy Research CrossRef
  10. USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma
    Huijuan Zhang et al, 2018, Cancer Letters CrossRef
  11. CRISPR-Cas9 therapies in experimental mouse models of cancer
    Diogo Estêvão et al, 2018, Future Oncology CrossRef
  12. Molecular Pathogenesis of Nonalcoholic Steatohepatitis- (NASH-) Related Hepatocellular Carcinoma
    Ozlem Kutlu et al, 2018, Canadian Journal of Gastroenterology and Hepatology CrossRef
  13. Identification of eight meta-signature miRNAs as potential biomarkers for Oropharyngeal Cancers
    Bo Li et al, 2018, Cancer Genetics CrossRef
  14. Molecular Action of Herbal Antioxidants in Regulation of Cancer Growth: Scope for Novel Anticancer Drugs
    Manjula Vinayak, 2018, Nutrition and Cancer CrossRef
  15. Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence
    Ben Sang et al, 2018, Proc Natl Acad Sci USA CrossRef
  16. Silencing of long noncoding RNA HOXD-AS1 inhibits proliferation, cell cycle progression, migration and invasion of hepatocellular carcinoma cells through MEK/ERK pathway
    Jin Sun et al, 2019, J Cell Biochem CrossRef
  17. Design, synthesis, and anticancer activity of iridium(III) complex-peptide hybrids that contain hydrophobic acyl groups at the N-terminus of the peptide units
    Kana Naito et al, 2019, Journal of Inorganic Biochemistry CrossRef
  18. NAD(P)H Quinone Dehydrogenase 1 Ablation Inhibits Activation of the Phosphoinositide 3-Kinase/Akt Serine/Threonine Kinase and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathways and Blocks Metabolic Adaptation in Hepatocellular Carcinoma.
    Manali Dimri et al, 2020, Hepatology CrossRef
  19. RRAS2 knockdown suppresses osteosarcoma progression by inactivating the MEK/ERK signaling pathway
    Kejun Wang et al, 2019, Anti-Cancer Drugs CrossRef
  20. Kinase Inhibitors and Ovarian Cancer
    null Katopodis et al, 2019, Cancers CrossRef
  21. Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma
    Jacopo Gavini et al, 2019, Cell Death Dis CrossRef
  22. Sevoflurane induces apoptosis and inhibits the growth and motility of colon cancer in vitro and in vivo via inactivating Ras/Raf/MEK/ERK signaling
    Xiao Yang et al, 2019, Life Sciences CrossRef
  23. Exploring Proteomic Drug Targets, Therapeutic Strategies and Protein - Protein Interactions in Cancer: Mechanistic View
    Khalid Bashir Dar et al, 2019, CCDT CrossRef
  24. miR‐4510 blocks hepatocellular carcinoma development through RAF1 targeting and RAS/RAF/MEK/ERK signalling inactivation
    Amani Ghousein et al, 2019, Liver Int CrossRef
  25. RAS/RAF/MEK/ERK, PI3K/PTEN/AKT/mTORC1 and TP53 pathways and regulatory miRs as therapeutic targets in hepatocellular carcinoma
    Shaw M. Akula et al, 2019, Expert Opinion on Therapeutic Targets CrossRef
  26. Current discovery strategies for hepatocellular carcinoma therapeutics
    Qiuzi Dai et al, 2019, Expert Opinion on Drug Discovery CrossRef
  27. Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma.
    Nancy S Younis et al, 2019, Sci Rep CrossRef
  28. null
    Rebecca Allen et al, 2020 CrossRef
  29. PHD2 acts as an oncogene through activation of Ras/Raf/MEK/ERK and JAK1/STAT3 pathways in human hepatocellular carcinoma cells
    Junqiang Guo et al, 2020, Artificial Cells, Nanomedicine, and Biotechnology CrossRef
  30. Cyclosporin A activates human hepatocellular carcinoma (HepG2 cells) proliferation: implication of EGFR-mediated ERK1/2 signaling pathway
    Mohammed E. Abo-El Fetoh et al, 2020, Naunyn-Schmiedeberg's Arch Pharmacol CrossRef
  31. SSIPe: accurately estimating protein–protein binding affinity change upon mutations using evolutionary profiles in combination with an optimized physical energy function
    Xiaoqiang Huang et al, 2019 CrossRef
  32. Apigenin, A Plant Flavone Playing Noble Roles in Cancer Prevention Via Modulation of Key Cell Signaling Networks
    Deepti Singh et al, 2020, PRA CrossRef
  33. Single high dose irradiation induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cells through the Ras/Raf/MEK/ERK pathways
    XiaoQiang Tian et al, 2020, International Journal of Radiation Biology CrossRef
  34. Validation of miR-20a as a Tumor Suppressor Gene in Liver Carcinoma Using Hepatocyte-Specific Hyperactive piggyBac Transposons
    Jaitip Tipanee et al, 2020, Molecular Therapy - Nucleic Acids CrossRef
  35. Molecular Signaling Pathways and Therapeutic Targets in Hepatocellular Carcinoma.
    Manali Dimri et al, 2020, Cancers (Basel) CrossRef
  36. Oxymatrine Inhibits Proliferation and Migration of Vulvar Squamous Cell Carcinoma Cells via Attenuation of the RAS/RAF/MEK/ERK Pathway


    Yanshi Wang et al, 2020, CMAR CrossRef
  37. Targeted Gene Silencing BRAF Synergized Photothermal Effect Inhibits Hepatoma Cell Growth Using New GAL-GNR-siBRAF Nanosystem
    Yanling Liu et al, 2020, Nanoscale Res Lett CrossRef
  38. Progress in the correlation between PTPN12 gene expression and human tumors
    Yu-hu Huo et al, 2020 CrossRef
  39. Potential dual functional roles of the Y‐linked RBMY in hepatocarcinogenesis
    Tatsuo Kido et al, 2020, Cancer Sci CrossRef
  40. Treatment with a New Barbituric Acid Derivative Exerts Antiproliferative and Antimigratory Effects against Sorafenib Resistance in Hepatocellular Carcinoma
    Yi-Jen Liao et al, 2020, Molecules CrossRef
  41. Bone mesenchymal stem cells are recruited via CXCL8‐CXCR2 and promote EMT through TGF‐β signal pathways in oral squamous carcinoma
    Lin Meng et al, 2020, Cell Prolif CrossRef
  42. Enhanced anti-hepatoma effect of a novel curcumin analog C086 via solid dispersion technology
    Yanping Deng et al, 2020, Drug Delivery CrossRef
  43. Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis.
    Xiaowei Zhang et al, 2020, Acta Pharm Sin B CrossRef
  44. Integration of RNA-seq and RNAi provides a novel insight into the immune responses of Epinephelus coioides to the impB gene of Pseudomonas plecoglossicida
    Zixu Liu et al, 2020, Fish & Shellfish Immunology CrossRef
  45. ERK/MAPK signalling pathway and tumorigenesis.
    Yan-Jun Guo et al, 2020, Exp Ther Med CrossRef
  46. Resolvin D1 inhibits the proliferation of lipopolysaccharide‑treated HepG2 hepatoblastoma and PLC/PRF/5 hepatocellular carcinoma cells by targeting the MAPK pathway
    You Lu et al, 2018, Exp Ther Med CrossRef
  47. The coordinated effects of Apatinib and Tripterine on the proliferation, invasiveness and apoptosis of human hepatoma Hep3B cells
    Huihui Li et al, 2018, Oncol Lett CrossRef
  48. Sphingosine-1-phosphate promotes PDGF-dependent endothelial progenitor cell angiogenesis in human chondrosarcoma cells
    Chao-Qun Wang et al, 2019, Aging CrossRef
  49. Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma
    Md Gulam Musawwir Khan et al, 2020, BMC Cancer CrossRef
  50. Extract Derived from Cedrus atlantica Acts as an Antitumor Agent on Hepatocellular Carcinoma Growth In Vitro and In Vivo.
    Gwo-tarng Sheu, 0 CrossRef
  51. Overexpression of Galectin-1 and Galectin-3 in hepatocellular carcinoma
    Tahereh Setayesh et al, 2020, Liver Research CrossRef
  52. Sophoridine suppresses lenvatinib‐resistant hepatocellular carcinoma growth by inhibiting RAS/MEK/ERK axis via decreasing VEGFR2 expression
    Zhongwei Zhao et al, 2020, J Cell Mol Med CrossRef
  53. Etiology of Hepatocellular Carcinoma: Special Focus on Fatty Liver Disease
    Diwakar Suresh et al, 2020, Front. Oncol. CrossRef
  54. Melatonin inhibiting the survival of human gastric cancer cells under ER stress involving autophagy and Ras-Raf-MAPK signalling.
    Yongye Huang et al, 2021, J Cell Mol Med CrossRef
  55. Characterization and management of ERK inhibitor associated dermatologic adverse events: analysis from a nonrandomized trial of ulixertinib for advanced cancers
    J. Wu et al, 2021, Invest New Drugs CrossRef
  56. Prognostic Nomogram for Sorafenib Benefit in Hepatitis B Virus-Related Hepatocellular Carcinoma After Partial Hepatectomy
    Wei Dong et al, 2021, Front. Oncol. CrossRef
  57. Natural Progression of Non-Alcoholic Steatohepatitis to Hepatocellular Carcinoma
    Daryl Ramai et al, 2021, Biomedicines CrossRef
  58. High Expression of LINC01268 is Positively Associated with Hepatocellular Carcinoma Progression via Regulating MAP3K7
    Xiuli Jin et al, 2021, OTT CrossRef
  59. In Pursuit of a Selective Hepatocellular Carcinoma Therapeutic Agent: Novel Thalidomide Derivatives with Antiproliferative, Antimigratory and STAT3 Inhibitory Properties
    Michael J. Nutt et al, 2021, European Journal of Medicinal Chemistry CrossRef
  60. Longitudinal assessment of B-RAF V595E levels in the peripheral cell-free tumor DNA of a 10-year-old spayed female Korean Jindo dog with unresectable metastatic urethral transitional cell carcinoma for monitoring the treatment response to a RAF inhibitor (sorafenib)
    Jung-Hyun Kim et al, 2021, Veterinary Quarterly CrossRef
  61. null
    Utibe-Abasi Udoh et al, 2021 CrossRef
  62. Induction of Apoptosis in Hepatocellular Carcinoma Cell Lines by Novel Indolylacrylamide Derivatives: Synthesis and Biological Evaluation
    Mohammed Hawash et al, 2021, Chem. Biodiversity CrossRef
  63. Suppression of Heterogeneous Nuclear Ribonucleoprotein C Inhibit Hepatocellular Carcinoma Proliferation, Migration, and Invasion via Ras/MAPK Signaling Pathway
    Jiejun Hu et al, 2021, Front. Oncol. CrossRef
  64. Anti‐hepatic fibrosis effects of AD‐2 affecting the Raf–MEK signaling pathway and inflammatory factors in thioacetamide‐induced liver injury
    Tao Li et al, 2021, Journal of Food Science CrossRef
  65. pH-Responsive Pluronic F127–Lenvatinib-Encapsulated Halogenated Boron-Dipyrromethene Nanoparticles for Combined Photodynamic Therapy and Chemotherapy of Liver Cancer
    Jingjing Zong et al, 2021, ACS Omega CrossRef
  66. mascRNA and its parent lncRNA MALAT1 promote proliferation and metastasis of hepatocellular carcinoma cells by activating ERK/MAPK signaling pathway
    Shu-Juan Xie et al, 2021, Cell Death Discov. CrossRef
  67. Hepatocrinology
    Sanjay Kalra et al, 2021, Medical Sciences CrossRef
  68. Knockdown of Atg7 suppresses Tumorigenesis in a murine model of liver cancer
    Kyung Joo Cho et al, 2021, Translational Oncology CrossRef
  69. Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma☆
    Fang Wang et al, 2021, Liver Research CrossRef
  70. Cancer - dysregulation of the cell cycle and transduction of cascade signals
    Akhmad Madaminov et al, 2021 CrossRef
  71. Targeting molecular signal transduction pathways in hepatocellular carcinoma and its implications for cancer therapy
    Ishfaq Hassan Mir et al, 2021, Cell Biol Int CrossRef
  72. Emerging treatment modalities for systemic therapy in hepatocellular carcinoma
    Xin Qing et al, 2021, Biomark Res CrossRef
  73. MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration
    Hai-Jun Zhang et al, 2021, Biomedicine & Pharmacotherapy CrossRef
  74. Identification of potential targets with high centrality indicated by diethylnitrosamine + thioacetamide-induced hepatocellular carcinoma model
    Sandhya Hora et al, 2021, J Can Res Ther CrossRef
  75. A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery
    Emilie Crouchet et al, 2021, Nat Commun CrossRef
  76. Cetuximab–siRNA Conjugate Linked Through Cationized Gelatin Knocks Down KRAS G12C Mutation in NSCLC Sensitizing the Cells Toward Gefitinib
    K. Sreedurgalakshmi et al, 2021, Technol Cancer Res Treat CrossRef
  77. Cysteine‐rich intestinal protein 1 enhances the progression of hepatocellular carcinoma via Ras signaling
    Hong‐Yu He et al, 2021, The Kaohsiung Journal of Medical Sciences CrossRef
  78. Antibody–drug conjugate as targeted therapeutics against hepatocellular carcinoma: preclinical studies and clinical relevance
    M. Murali et al, 2021, Clin Transl Oncol CrossRef
  79. Natural resorcylic acid lactones: a chemical biology approach for anticancer activity
    Shilpa Kuttikrishnan et al, 2021, Drug Discovery Today CrossRef
  80. Cilostazol Induces Apoptosis and Inhibits Proliferation of Hepatocellular Carcinoma Cells by Activating AMPK
    Kyeong Hwa Sim et al, 2021, Biotechnol Bioproc E CrossRef
  81. Targeting the PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma.
    Eun Jin Sun et al, 2021, Biomedicines CrossRef
  82. Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease: From Epidemiology to Diagnostic Approach
    Ivica Grgurevic et al, 2021, Cancers CrossRef
  83. Sorafenib resistance and autophagy in hepatocellular carcinoma: A concealed threat
    K Ashokachakkaravarthy et al, 2019, J Cancer Res Pract CrossRef
  84. Recent Progress in Lymphangioma
    Xiaowei Liu et al, 2021, Front. Pediatr. CrossRef
  85. The Research Progress of Trastuzumab-Induced Cardiotoxicity in HER-2-Positive Breast Cancer Treatment
    Mengmeng Lin et al, 2022, Front. Cardiovasc. Med. CrossRef
  86. Transforming Growth Factor-β Activated Kinase 1 (Tak1) Is Activated in Hepatocellular Carcinoma, Mediates Tumor Progression, and Predicts Unfavorable Outcome
    Dirk Andreas Ridder et al, 2022, Cancers CrossRef
  87. c-Met up-regulates the expression of PD-L1 through MAPK/NF-κBp65 pathway
    Ruyue Xu et al, 2022, J Mol Med CrossRef
  88. Qa-1b functions as an oncogenic factor in mouse melanoma cells
    Xiang Guo et al, 2022, Journal of Dermatological Science CrossRef
  89. Identifying Potential New Gene Expression-Based Biomarkers in the Peripheral Blood Mononuclear Cells of Hepatitis B-Related Hepatocellular Carcinoma
    Vahdat Poortahmasebi et al, 2022, Canadian Journal of Gastroenterology and Hepatology CrossRef
  90. PPP1R26 drives hepatocellular carcinoma progression by controlling glycolysis and epithelial-mesenchymal transition
    Yang Yang et al, 2022, J Exp Clin Cancer Res CrossRef
  91. Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF/MEK/ERK pathway
    Ying Zhang et al, 2022, npj Breast Cancer CrossRef
  92. HIV-1-Mediated Acceleration of Oncovirus-Related Non-AIDS-Defining Cancers
    Jessica Proulx et al, 2022, Biomedicines CrossRef
  93. Context dependent role of p53 during the interaction of hepatocellular carcinoma and endothelial cells
    Shaikh Maryam Ghufran et al, 2022, Microvascular Research CrossRef
  94. Novel antiproliferative agents bearing substituted thieno[2,3-d]pyrimidine scaffold as dual VEGFR-2 and BRAF kinases inhibitors and apoptosis inducers; design, synthesis and molecular docking
    Rasha A. Hassan et al, 2022, Bioorganic Chemistry CrossRef
  95. Identification of Context-Specific Fitness Genes Associated With Metabolic Rearrangements for Prognosis and Potential Treatment Targets for Liver Cancer
    Shizhe Yu et al, 2022, Front. Genet. CrossRef
  96. Network Pharmacology-Based Strategy to Investigate the Mechanisms of Lenvatinib in the Treatment of Hepatocellular Carcinoma
    P. Liu et al, 2022, Computational Intelligence and Neuroscience CrossRef
  97. Targeting the effect of sofosbuvir on selective oncogenes expression level of hepatocellular carcinoma Ras/Raf/MEK/ERK pathway in Huh7 cell line
    Muhammad Atif et al, 2022, Saudi Journal of Biological Sciences CrossRef
  98. miRCom: Tensor completion integrating multi-view information to deduce the potential disease-related miRNA-miRNA pairs
    Pei Liu et al, 2020, IEEE/ACM Trans. Comput. Biol. and Bioinf. CrossRef
  99. null
    Bubu A. Banini et al, 2021 CrossRef
  100. Research Progresses of Targeted Therapy and Immunotherapy for Hepatocellular Carcinoma
    Tao Wang et al, 2021, CMC CrossRef
  101. Improving the Therapeutic Efficacy of Sorafenib for Hepatocellular Carcinoma by Repurposing Disulfiram
    Gong Zhang et al, 2022, Front. Oncol. CrossRef
  102. Centromere protein F promotes progression of hepatocellular carcinoma through ERK and cell cycle-associated pathways.
    Hongjin Chen et al, 2021, Cancer Gene Ther CrossRef
  103. Natural Antioxidant, Antibacterial, and Antiproliferative Activities of Ethanolic Extracts from Punica granatum L. Tree Barks Mediated by Extracellular Signal-Regulated Kinase
    Arpron Leesombun et al, 2022, Plants CrossRef
  104. Key signal transduction pathways and crosstalk in cancer: Biological and therapeutic opportunities
    Dongliao Fu et al, 2022, Translational Oncology CrossRef
  105. Inhibitory Effect of miR-504-Loaded Magnetic Iron Oxide Nanoparticles on Oral Cancer Through Regulation of Cyclin-Dependent Kinase 6 to Mediate Extracellular Regulated Kinase Signaling Pathway
    Jing Yu et al, 2022, sci adv mater CrossRef
  106. NEIL3 promotes hepatoma epithelial–mesenchymal transition by activating the BRAF / MEK / ERK / TWIST signaling pathway
    Hui‐Huang Lai et al, 2022, The Journal of Pathology CrossRef
  107. MEK-inhibitors in treatment of Langerhans cell histiocytosis
    E. A. Burtsev et al, 2022, Ross. ž. det. gematol. onkol. CrossRef
  108. Therapeutic targeting of hepatocellular carcinoma cells with antrocinol, a novel, dual-specificity, small-molecule inhibitor of the KRAS and ERK oncogenic signaling pathways
    Chia-Hung Hsu et al, 2022, Chemico-Biological Interactions CrossRef
  109. Multiomics Integration at Single-Cell Resolution Using Bayesian Networks: A Case Study in Hepatocellular Carcinoma
    Muntadher Jihad et al, 2023, OMICS: A Journal of Integrative Biology CrossRef
  110. Role of HIF ‐1α in pathogenic mechanisms of keloids
    Zi‐kai Qiu et al, 2023, J of Cosmetic Dermatology CrossRef