1. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway.
   Nan Feng et al, 2016, Mol Med Rep CrossRef
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   Shuwen Han et al, 2017 CrossRef
3. Secreted frizzled-related protein 1 (SFRP1) gene methylation changes in the human lung adenocarcinoma cells treated with L-securinine
   Xi Yang et al, 2018, Journal of Asian Natural Products Research CrossRef
4. L-securinine inhibits cell growth and metastasis of human androgen-independent prostate cancer DU145 cells via regulating mitochondrial and AGTR1/MEK/ERK/STAT3/PAX2 apoptotic pathways
   Dongxu Zhang et al, 2019, Biosci. Rep. CrossRef
5. Oridonin inhibits mTOR signaling and the growth of lung cancer tumors
   Yan-Yan Wang et al, 2014, Anti-Cancer Drugs CrossRef
6. Bio‐inspired Total Synthesis of Twelve Securinega Alkaloids: Structural Reassignments of (+)‐Virosine B and (−)‐Episecurinol A
   Kevin Antien et al, 2019, Chem. Eur. J. CrossRef
7. Alteration of Gene Expression Profiling Including GPR174 and GNG2 is Associated with Vasovagal Syncope
   Yu-Juan Huang et al, 2015, Pediatr Cardiol CrossRef
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   Egor Chirkin et al, 2015 CrossRef
9. Securinine disturbs redox homeostasis and elicits oxidative stress-mediated apoptosis via targeting thioredoxin reductase
   Junmin Zhang et al, 2017, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease CrossRef
10. Securinine from Phyllanthus glaucus Induces Cell Cycle Arrest and Apoptosis in Human Cervical Cancer HeLa Cells
    Justyna Stefanowicz-Hajduk et al, 2016, PLoS ONE CrossRef
11. Vernodalol mediates antitumor effects in acute promyelocytic leukemia cells
    Wenjun Wu et al, 2017, Oncol Lett CrossRef
12. Securinine Induces Differentiation of Human Promyelocytic Leukemic HL-60 Cells through JNK-Mediated Signaling Pathway
    Jeetesh Sharma et al, 2021, Nutrition and Cancer CrossRef
13. Unique indolizidine alkaloid securinine is a promising scaffold for the development of neuroprotective and antitumor drugs
    Sergey Klochkov et al, 2021, RSC Adv. CrossRef
14. Chinese Medicine Leptochloa chinensis Inhibits the Malignant Behaviors of Renal Cell Carcinoma 786-O Cells by Regulating the mTOR Pathway
    Yongshun Tan et al, 2021, Evidence-Based Complementary and Alternative Medicine CrossRef
15. Securinine induces mitotic block in cancer cells by binding to tubulin and inhibiting microtubule assembly: A possible mechanistic basis for its anticancer activity
    Shabeeba M. Ashraf et al, 2021, Life Sciences CrossRef
16. Structure simplification of the Securinine skeleton reveals the importance of BCD ring system for the cytotoxic activity on HCT116 and HL60 cell lines
    Myriam Le Roch et al, 2022, Bioorganic & Medicinal Chemistry CrossRef
17. Research Progress of Natural Small-Molecule Compounds Related to Tumor Differentiation
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18. Potential anticancer activities of securinine and its molecular targets
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19. Bioactivities and mechanism of action of securinega alkaloids derivatives reported prior to 2022
    Wen Hou et al, 2023, Biomedicine & Pharmacotherapy CrossRef
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