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  3. Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
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  4. Imperatorin efficiently blocks TNF-α-mediated activation of ROS/PI3K/Akt/NF-κB pathway.
    Ke Si Wang et al, 2017, Oncol Rep CrossRef
  5. Celastrol synergizes with oral nifedipine to attenuate hypertension in preeclampsia: a randomized, placebo-controlled, and double blinded trial
    Sha Xiao et al, 2017, Journal of the American Society of Hypertension CrossRef
  6. Celastrol induces apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway
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  7. Optimization on biodistribution and antitumor activity of tripterine using polymeric nanoparticles through RES saturation
    Juntao Yin et al, 2017, Drug Delivery CrossRef
  8. Preliminary study on fabrication, characterization and synergistic anti-lung cancer effects of self-assembled micelles of covalently conjugated celastrol–polyethylene glycol–ginsenoside Rh2
    Peng Li et al, 2017, Drug Delivery CrossRef
  9. Celastrol negatively regulates cell invasion and migration ability of human osteosarcoma via downregulation of the PI3K/Akt/NF-κB signaling pathway in vitro
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  10. Simultaneous targeting therapy for lung metastasis and breast tumor by blocking the NF-κB signaling pathway using Celastrol-loaded micelles
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  11. Celastrol attenuates symptoms of preeclampsia in rats by inhibiting matrix metalloproteinase-9
    Sha Xiao et al, 2018, European Journal of Pharmacology CrossRef
  12. Molecular targets of celastrol in cancer: Recent trends and advancements
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  13. Targeting transcription factor STAT3 for cancer prevention and therapy.
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  14. Celastrol improves the therapeutic efficacy of EGFR-TKIs for non-small-cell lung cancer by overcoming EGFR T790M drug resistance
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  15. Celastrol induces vincristine multidrug resistance oral cancer cell apoptosis by targeting JNK1/2 signaling pathway
    Fu-Zhen Lin et al, 2018, Phytomedicine CrossRef
  16. Casticin inhibits breast cancer cell migration and invasion by down-regulation of PI3K/Akt signaling pathway
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  17. Celastrol suppresses nitric oxide synthases and the angiogenesis pathway in colorectal cancer
    Yanfeng Gao et al, 2019, Free Radical Research CrossRef
  18. Tripterine inhibits proliferation, migration and invasion of breast cancer MDA-MB-231 cells by up-regulating microRNA-15a.
    Anjun Zuo et al, 2019, Biol Chem CrossRef
  19. Celastrol Attenuates Intrahepatic Cholestasis of Pregnancy by Inhibiting Matrix Metalloproteinases-2 and 9
    Junjun Guo et al, 2019, Annals of Hepatology CrossRef
  20. Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer
    Hyojin Kim et al, 2015, Virchows Arch CrossRef
  21. Enhanced bioavailability of tripterine through lipid nanoparticles using broccoli-derived lipids as a carrier material
    Wan Li et al, 2015, International Journal of Pharmaceutics CrossRef
  22. Inhibiting inducible miR-223 further reduces viable cells in human cancer cell lines MCF-7 and PC3 treated by celastrol
    Lu Cao et al, 2015, BMC Cancer CrossRef
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  24. Anti-proliferative Effects of Celastrol, A Quinine Methide Triterpene Extracted from the Perennial Vine Tripterygium wilfordii, on Obesity-related Cancers
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  26. 22β-hydroxytingenone reduces proliferation and invasion of human melanoma cells
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  27. Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine
    Qi-Wei Jiang et al, 2015, Oncotarget CrossRef
  28. Celastrol inhibits ezrin-mediated migration of hepatocellular carcinoma cells.
    Shihao Du et al, 2020, Sci Rep CrossRef
  29. Axl is a novel target of celastrol that inhibits cell proliferation and migration, and increases the cytotoxicity of gefitinib in EGFR mutant non‑small cell lung cancer cells
    Youn Lee et al, 2019, Mol Med Report CrossRef
  30. Efficacy of celastrol combined with cisplatin in enhancing the apoptosis of U‑2OS osteosarcoma cells via the mitochondrial and endoplasmic reticulum pathways of apoptosis
    Qiang Wang et al, 2019, Oncol Lett CrossRef
  31. Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP‑9 signaling pathways in human bladder cancer cells
    Tian Li et al, 2018, Oncol Lett CrossRef
  32. Biosynthesis, total synthesis, structural modifications, bioactivity, and mechanism of action of the quinone‐methide triterpenoid celastrol
    Yun Lu et al, 2020, Med Res Rev CrossRef
  33. 22β-hydroxytingenone induces apoptosis and suppresses invasiveness of melanoma cells by inhibiting MMP-9 activity and MAPK signaling
    Elenn Suzany Pereira Aranha et al, 2020, Journal of Ethnopharmacology CrossRef
  34. A Combined Systemic Strategy for Overcoming Cisplatin Resistance in Head and Neck Cancer: From Target Identification to Drug Discovery
    Yin-Ju Chen et al, 2020, Cancers CrossRef
  35. Nanoparticles based on polymers modified with pH-sensitive molecular switch and low molecular weight heparin carrying Celastrol and ferrocene for breast cancer treatment
    Yun Qian et al, 2021, International Journal of Biological Macromolecules CrossRef
  36. Synthesis, computational docking and biological evaluation of celastrol derivatives as dual inhibitors of SERCA and P-glycoprotein in cancer therapy
    Paolo Coghi et al, 2021, European Journal of Medicinal Chemistry CrossRef
  37. Based on Network Pharmacology Tools to Investigate the Mechanism of Tripterygium wilfordii Against IgA Nephropathy
    Ming Xia et al, 2021, Front. Med. CrossRef
  38. Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin
    Na Hui Kim et al, 2022, Acta Pharmacol Sin CrossRef
  39. Synergetic HepG2 cells suppression efficacy of Tripterygium wilfordii and Scutellaria barbata through EGFR/PI3K/Akt pathway
    Susu Liu et al, 2022, Pharmacological Research - Modern Chinese Medicine CrossRef
  40. Assembly of Celastrol to Zeolitic Imidazolate Framework-8 by Coordination as a Novel Drug Delivery Strategy for Cancer Therapy
    Na Wang et al, 2022, Pharmaceuticals CrossRef
  41. Celastrol Supplementation Ablates Sexual Dimorphism of Abdominal Aortic Aneurysm Formation in Mice
    Aida Javidan et al, 2023, Biomolecules CrossRef
  42. Exploring the anti‐cancer potential of dietary phytochemicals for the patients with breast cancer: A comprehensive review
    Md Sohel et al, 2023, Cancer Medicine CrossRef
  43. Celastrol relieves myocardial infarction-induced cardiac fibrosis by inhibiting NLRP3 inflammasomes in rats
    Jiwen Fan et al, 2023, International Immunopharmacology CrossRef
  44. Celastrol promotes apoptosis of breast cancer MDA-MB-231 cells by targeting HSDL2
    Li Liu et al, 2024 CrossRef
  45. Inhibiting AGS Cancer Cell Proliferation through the Combined Application of Aucklandiae Radix and Hyperthermia: Investigating the Roles of Heat Shock Proteins and Reactive Oxygen Species
    Chae Ryeong Ahn et al, 2024, Antioxidants CrossRef
  46. Exploring medicinal potential and drug delivery solutions of Celastrol from the Chinese "Thunder of God Vine"
    Zimo Ren et al, 2024, Eur. J. Chem. CrossRef