TY - JOUR AB - Nicotine, the primary addictive constituent of cigarettes, is believed to contribute to cancer promotion and progression through the activation of nicotinic acetylcholine receptors (nAChRs), which are membrane ligand‑gated cation channels. nAChRs activation can be triggered by the neurotransmitter Ach, or certain other biological compounds, such as nicotine. In recent years, genome‑wide association studies have indicated that allelic variation in the α5‑α3‑β4 nAChR cluster on chromosome 15q24‑15q25.1 is associated with lung cancer risk. The role of nAChRs in other types of cancer has also been reported. The present review highlights the role of nAChRs in types of human cancer. AD - Department of Dermatology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, P.R. China AU - Dang,Ningning AU - Meng,Xianguang AU - Song,Haiyan DA - 2016/05/01 DO - 10.3892/br.2016.625 EP - 518 IS - 5 JO - Biomed Rep KW - nicotinic acetylcholine receptor cancer tobacco PY - 2016 SN - 2049-9434 2049-9442 SP - 515 ST - Nicotinic acetylcholine receptors and cancer (Review) T2 - Biomedical Reports TI - Nicotinic acetylcholine receptors and cancer (Review) UR - https://doi.org/10.3892/br.2016.625 VL - 4 ER -