TY - JOUR AB - Dietary fat is an important determinant in the development and progression of high blood pressure (BP), a major risk factor for cardiovascular diseases and mortality. The aim of the present study was to determine the association between plasma phospholipid fatty acids and hypertension in Japanese men. The plasma level of linoleic acid (LA) in the subjects with hypertension (systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg) was identified to be significantly higher than that in the healthy controls. Following adjustment for age, body mass index, physical activity, smoking status, alcohol consumption, salt intake, and serum levels of glucose and hemoglobin A1c, higher plasma levels of LA and α-linolenic acid (ALA), and lower levels of arachidonic acid (AA) were significantly associated with a lower prevalence of hypertension. The odds ratio (OR) for the highest quartile (Q4) versus the lowest quartile (Q1) of LA was 0.17 (P=0.003), the OR for Q4 versus Q1 of ALA was 0.26 (P=0.042) and the OR for Q4 versus Q1 of AA was 2.04 (P=0.047). These results indicate that elevated levels of LA and ALA, and reduced levels of AA in the plasma prevent hypertension. AD - Department of Food Science and Nutrition, Nara Women's University, Kitauoya-Nishimachi, Nara 630-8506, Japan AU - Tsukamoto,Ikuyo AU - Sugawara,Shiori DA - 2018/01/01 DO - 10.3892/br.2017.1015 EP - 76 IS - 1 JO - Biomed Rep KW - hypertension plasma fatty acid α-linolenic acid linoleic acid arachidonic acid PY - 2018 SN - 2049-9434 2049-9442 SP - 69 ST - Low levels of linoleic acid and α-linolenic acid and high levels of arachidonic acid in plasma phospholipids are associated with hypertension T2 - Biomedical Reports TI - Low levels of linoleic acid and α-linolenic acid and high levels of arachidonic acid in plasma phospholipids are associated with hypertension UR - https://doi.org/10.3892/br.2017.1015 VL - 8 ER -