TY - JOUR AB - Anterior cruciate ligament (ACL) rupture is one the most common musculoskeletal soft tissue injuries of the knee. Although the exact mechanisms of this injury remain uncertain, genetic variants have been considered to be an intrinsic risk factor associated with ACL rupture. Therefore, the aim of the present study was to determine whether the adiponectin +276G/T polymorphism is associated with susceptibility to ACL rupture in a Thai population. Genotyping for rs1501299 was conducted in 98 participants with ACL rupture and 95 healthy controls by polymerase chain reaction‑restriction fragment length polymorphism analysis. The results demonstrated that the GG genotype and G allele were significantly associated with an increased risk of ACL rupture [odds ratio (OR)=1.91, P=0.026; OR=1.89, P=0.004], whereas the TT genotype was significantly associated with a reduced risk of ACL rupture (OR=0.32, P=0.019). Furthermore, ACL injury patients with non‑contact sports carrying the GG genotype and G allele exhibited a significantly higher risk of ACL rupture (OR=2.13, P=0.031; OR=1.84, P=0.029). In addition, overweight patients carrying the GG genotype and G allele had a significantly increased (8‑fold) risk of ACL rupture (OR=8.00, P<0.001; OR=5.15, P<0.001), whereas overweight patients with the adiponectin +276G/T GT genotype had a significantly lower risk of ACL rupture (OR=0.13, P<0.001). Therefore, the adiponectin +276G/T polymorphism GG genotype and G allele were significantly associated with the risk of ACL rupture, particularly in overweight patients. These findings indicate that the adiponectin +276G/T polymorphism may play a role in the development of ACL rupture in the Thai population. AD - Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand Vinai Parkpian Orthopaedic Research Center, Department of Orthopaedics, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok 10330, Thailand Osteoarthritis and Musculoskeleton Research Unit, Department of Biochemistry, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok 10330, Thailand Department of Preventive and Social Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Chulalongkorn University, Bangkok 10330, Thailand AU - Udomsinprasert,Wanvisa AU - Yuktanandana,Pongsak AU - Tanpowpong,Thanathep AU - Malila,Somkiat AU - Jiamjarasrangsi,Wiroj AU - Honsawek,Sittisak DA - 2019/02/01 DO - 10.3892/br.2018.1180 EP - 139 IS - 2 JO - Biomed Rep KW - anterior cruciate ligament adiponectin contact sport overweight polymorphisms PY - 2019 SN - 2049-9434 2049-9442 SP - 133 ST - Adiponectin gene rs1501299 polymorphism is associated with increased risk of anterior cruciate ligament rupture T2 - Biomedical Reports TI - Adiponectin gene rs1501299 polymorphism is associated with increased risk of anterior cruciate ligament rupture UR - https://doi.org/10.3892/br.2018.1180 VL - 10 ER -