TY - JOUR AB - Innate immunity serves an important role in the healthy population, providing surveillance and protection against infections. Chemotherapy suppresses the body's immune system, including neutrophil and natural killer (NK) cell numbers and activity. This leads to an increased risk of infection which often requires the reduction or even discontinuation of the chemotherapeutic regimens. The botanical formula LCS102 was designed to stimulate the body's immune system. The effect of the formula on innate immunity was examined in human blood samples, as were its effect on the anti‑cancer activity of chemotherapeutic agents on human cancer cells. Blood samples drawn from 20 volunteers (19 healthy subjects; 1 patient with breast cancer undergoing chemotherapy) and were exposed to LCS102. The effects on neutrophil and NK cell activity were tested using FACS. The anti‑cancer effects of LCS102 were tested on T24, A549, MCF7, PANC‑1 and U2OS human cancer cell lines, as were the effects of the formula on doxorubicin, Taxol, etoposide and cisplatin‑treated cells using a sulforodamine B viability assay. LCS102 was shown to significantly increase the percentage of activated neutrophils and NK cells in the blood samples tested. The formula did not inhibit the cytotoxic effects of the chemotherapeutic agents, and in certain cases increased their anti‑cancer activity. Further research is required to improve our understanding of the clinical value of LCS102; however, it may serve as an adjuvant during chemotherapy, to reduce the effects of chemotherapy on innate immunity. AD - Tal Center for Integrative Medicine, Institute of Oncology, Sheba Medical Center, Ramat Gan 52621, Israel Institute of Oncology, Sheba Medical Center, Ramat Gan 52621, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel AU - Cohen,Zoya AU - Maimon,Yair AU - Berger,Raanan AU - Morag,Ofir AU - Golan,Talia AU - Samuels,Noah DA - 2020/09/01 DO - 10.3892/br.2020.1323 IS - 3 JO - Biomed Rep KW - botanical formula LCS102 LCS101 innate immunity neutrophils natural killer cells PY - 2020 SN - 2049-9434 2049-9442 SP - 17 ST - Effect of the botanical compound LCS102 on innate immunity T2 - Biomedical Reports TI - Effect of the botanical compound LCS102 on innate immunity UR - https://doi.org/10.3892/br.2020.1323 VL - 13 ER -