TY - JOUR AB - The aim of the present study was to analyze the profiles of cardiac microRNAs (miRNAs/miRs) in healthy pregnant women and non‑pregnant controls. A total of 61 healthy women >18 years of age with singleton pregnancies in the third trimester were compared with 19 non‑pregnant controls. Specifically, expression of miRNAs associated with cardiac hypertrophy (miR‑1, miR‑17‑5, miR‑22, miR‑34a, miR‑124, miR‑133a, miR‑195, miR‑199a‑3p, miR‑199b, miR‑210, miR‑222 and miR‑1249) and miRNAs associated with cardiac hypertrophy and fibrosis (miR‑15b, miR‑21, miR‑26a, miR‑29‑a, miR‑29c, miR‑30c, miR‑101, miR‑146a, miR‑191, miR‑208a‑5p and miR‑328) were analyzed and compared with echocardiographic examination results. Both groups had similar cardiac miRNA expression profiles, but differed in quantitative evaluation. Women in the third trimester of physiological pregnancy exhibited downregulation of certain profibrotic miRNAs (miR‑21, miR‑30c and miR‑328), decreased expression of a hypertrophic and antimetabolic miRNAs (miR‑146a), downregulation of an antifibrotic miRNA (miR‑222), and downregulation of a hypertrophic miRNA (miR‑195). In pregnant women, the indices of systolic function were associated with miR‑195 expression, and an interplay between miR‑17‑5p and diastolic function was observed. While the profiles of cardiac miRNAs expressed in healthy pregnant women and healthy non‑pregnant controls were similar, these two groups differed in terms of expression of specific miRNAs. In the third trimester of physiological pregnancy, a downregulation of miR‑17‑5p, miR‑21, miR‑30c, miR‑146a, miR‑195, miR‑222 and miR‑328 was observed. The differences in the association between echocardiographic indices with miRNAs in pregnant and non‑pregnant women suggest that miRNAs regulate both the structure and function of the pregnant heart, influencing cardiac muscle thickness as well as systolic and diastolic function. AD - Department of Cardiology, Institute of Mother and Child, 01‑211 Warsaw, Poland Department of Applied Pharmacy, Medical University of Warsaw, 02‑097 Warsaw, Poland Department of Gynecology and Obstetrics, Institute of Mother and Child, 01‑211 Warsaw, Poland First Chair and Department of Cardiology, Medical University of Warsaw, 02‑097 Warsaw, Poland AU - Szczerba,Ewa AU - Zajkowska,Agnieszka AU - Bochowicz,Anna AU - Pankiewicz,Katarzyna AU - Szewczyk,Grzegorz AU - Opolski,Grzegorz AU - Maciejewski,Tomasz AU - Małecki,Maciej AU - Fijałkowska,Anna DA - 2020/11/01 DO - 10.3892/br.2020.1348 IS - 5 JO - Biomed Rep KW - cardiac adaptation volume overload pregnancy remodeling microRNA hypertrophy PY - 2020 SN - 2049-9434 2049-9442 SP - 41 ST - Downregulated expression of microRNAs associated with cardiac hypertrophy and fibrosis in physiological pregnancy and the association with echocardiographically‑evaluated myocardial function T2 - Biomedical Reports TI - Downregulated expression of microRNAs associated with cardiac hypertrophy and fibrosis in physiological pregnancy and the association with echocardiographically‑evaluated myocardial function UR - https://doi.org/10.3892/br.2020.1348 VL - 13 ER -