TY - JOUR AB - Human papillomavirus (HPV) is a small DNA virus that infects the basal keratinocytes of squamous epithelium in the skin, and in the oral and genital mucosa. Smoking and sexual behavior have been recognized as significant risk factors for oral HPV infection. In the present review, the findings of recent studies of oral HPV infection in relation to periodontitis are discussed, as well as periodontopathic bacteria and periodontal herpes virus. Previous research suggests that HPV localizes to the inflammatory periodontal tissue. Inflammatory periodontal pockets may thus act as a reservoir for HPV. The interactions between HPV and periodontopathic bacteria remain unclear, but it is hypothesized that oral HPV infection may be related to a characteristic oral microbiome. Smoking is associated with HPV and periodontitis, as smoking induces destruction of periodontal tissue and suppresses the host defense, allowing HPV to infect periodontal tissue. Carcinogenic HPV and periodontitis may lead to the development of oral cavity cancer. However, oral HPV E6/E7 expression (transcriptionally active HPV) has not yet been fully investigated in patients with periodontitis. Collectively, the evidence suggests that oral HPV prevalence may be associated with periodontitis. The effect of clinical factors (age, sex, smoking, immunosuppressive condition and vaccination) on oral HPV DNA prevalence should be considered when clarifying the relationship between oral HPV and periodontitis. Additionally, the sampling method should be carefully chosen to directly detect HPV DNA in periodontal tissues. AD - Department of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-ku, Hiroshima 734-8553, Japan AU - Shigeishi,Hideo AU - Sugiyama,Masaru AU - Ohta,Kouji DA - 2021/05/01 DO - 10.3892/br.2021.1416 IS - 5 JO - Biomed Rep KW - HPV periodontitis periodontopathic bacteria PY - 2021 SN - 2049-9434 2049-9442 SP - 40 ST - Relationship between the prevalence of oral human papillomavirus DNA and periodontal disease (Review) T2 - Biomedical Reports TI - Relationship between the prevalence of oral human papillomavirus DNA and periodontal disease (Review) UR - https://doi.org/10.3892/br.2021.1416 VL - 14 ER -