TY - JOUR
AB - Immune system dysregulation plays a role in the pathogenesis of complex human diseases, including psychiatric disorders. In addition, elevated levels of pro‑inflammatory cytokines, including tumor necrosis factor α (TNF‑α) may be conditioned by the presence of specific polymorphic variants. The present case‑controlled preliminary study evaluated the prevalence of TNFA gene single nucleotide polymorphisms (SNPs) G‑308A (rs1800629) and T‑1031C (rs1799964) in 83 Polish patients with depression by restriction fragment length polymorphism analysis. The results were compared with the frequencies of genotypes in a geographically‑ and ethnically‑matched group of individuals without depression. No statistically significant difference in genotype/allele frequency was observed for either SNP between the two groups. No association was found between the particular genotypes and selected demographic/clinical features, including sex, age at diagnosis or severity of depressive symptoms before/after pharmacotherapy. Thus, there does not appear to be any connection between the studied SNPs and the development and progression of depression; however, further studies are required with larger cohorts to better understand this aspect of depression.
AD - Laboratory of Molecular Diagnostics and Pharmacogenomics, Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Łódź, 90‑151 Łódź, Łódź Voivodeship, Poland
Department of Adult Psychiatry, Medical University of Łódź, 91‑229 Łódź, Łódź Voivodeship, Poland
AU - Jeleń,Agnieszka
AU - Żebrowska‑Nawrocka,Marta
AU - Szmajda‑Krygier,Dagmara
AU - Mazur,Katarzyna
AU - Gałecki,Piotr
AU - Balcerczak,Ewa
DA - 2021/12/01
DO - 10.3892/br.2021.1481
IS - 6
JO - Biomed Rep
KW - depression
pharmacogenetics
gene promoter
single nucleotide polymorphism
TNFA
PY - 2021
SN - 2049-9434
2049-9442
SP - 105
ST - Preliminary investigation of two promoter region polymorphisms of the TNFA gene in patients with recurrent depressive disorder
T2 - Biomedical Reports
TI - Preliminary investigation of two promoter region polymorphisms of the TNFA gene in patients with recurrent depressive disorder
UR - https://doi.org/10.3892/br.2021.1481
VL - 15
ER -