TY - JOUR AB - Immune system dysregulation plays a role in the pathogenesis of complex human diseases, including psychiatric disorders. In addition, elevated levels of pro‑inflammatory cytokines, including tumor necrosis factor α (TNF‑α) may be conditioned by the presence of specific polymorphic variants. The present case‑controlled preliminary study evaluated the prevalence of TNFA gene single nucleotide polymorphisms (SNPs) G‑308A (rs1800629) and T‑1031C (rs1799964) in 83 Polish patients with depression by restriction fragment length polymorphism analysis. The results were compared with the frequencies of genotypes in a geographically‑ and ethnically‑matched group of individuals without depression. No statistically significant difference in genotype/allele frequency was observed for either SNP between the two groups. No association was found between the particular genotypes and selected demographic/clinical features, including sex, age at diagnosis or severity of depressive symptoms before/after pharmacotherapy. Thus, there does not appear to be any connection between the studied SNPs and the development and progression of depression; however, further studies are required with larger cohorts to better understand this aspect of depression. AD - Laboratory of Molecular Diagnostics and Pharmacogenomics, Department of Pharmaceutical Biochemistry and Molecular Diagnostics, Medical University of Łódź, 90‑151 Łódź, Łódź Voivodeship, Poland Department of Adult Psychiatry, Medical University of Łódź, 91‑229 Łódź, Łódź Voivodeship, Poland AU - Jeleń,Agnieszka AU - Żebrowska‑Nawrocka,Marta AU - Szmajda‑Krygier,Dagmara AU - Mazur,Katarzyna AU - Gałecki,Piotr AU - Balcerczak,Ewa DA - 2021/12/01 DO - 10.3892/br.2021.1481 IS - 6 JO - Biomed Rep KW - depression pharmacogenetics gene promoter single nucleotide polymorphism TNFA PY - 2021 SN - 2049-9434 2049-9442 SP - 105 ST - Preliminary investigation of two promoter region polymorphisms of the TNFA gene in patients with recurrent depressive disorder T2 - Biomedical Reports TI - Preliminary investigation of two promoter region polymorphisms of the TNFA gene in patients with recurrent depressive disorder UR - https://doi.org/10.3892/br.2021.1481 VL - 15 ER -