TY - JOUR AB - In addition to respiratory failure, another important outcome presented by patients hospitalized with coronavirus disease 2019 (COVID‑19) is renal failure, which is related to increased severity of infection and a greater risk of mortality. Severity is often represented by the need for respiratory and/or life support, which can range from oxygen therapy to invasive mechanical ventilation. This study aimed to determine the association between the degree of renal and inflammatory impairment in patients with the need for advanced respiratory support and mortality. Included in the present study were 79 critically ill patients with COVID‑19 on different days, who required a nasal cannula and/or orotracheal intubation. Data from laboratory tests, arterial blood gases and information on their clinical evolution were collected. The results obtained showed that the biochemical markers of renal function, as well as the inflammatory markers and the partial pressure of carbon dioxide, were significantly increased in patients who succumbed to the infection. Similarly, these markers were higher amongst patients who required increased respiratory assistance. AD - Multicentric Postgraduate Program in Physiological Sciences, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte 59607-360, Brazil Department of Biomedical Sciences, University of Rio Grande do Norte State, Mossoró, Rio Grande do Norte 59607-360, Brazil Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte 59078‑970, Brazil AU - De Morais,Nickson,Melo AU - De Morais Leone,Lara,Candice Costa AU - De Almeida,Valéria,Duarte AU - De Andrade,Micássio,Fernandes AU - Do Nascimento,Ellany,Gurgel Cosme AU - Fernandes,José,Veríssimo AU - Bezerra,Christiane,Medeiros AU - De Medeiros Fernandez,Thales,Allyrio Araújo DA - 2022/03/01 DO - 10.3892/br.2022.1501 IS - 3 JO - Biomed Rep KW - coronavirus disease 2019 SARS‑CoV‑2 respiratory therapy airway management kidney function tests acute kidney injury inflammatory mediators PY - 2022 SN - 2049-9434 2049-9442 SP - 18 ST - Changes in renal function increase the need for advanced ventilatory support and increase the risk of mortality in critically ill patients with COVID‑19 T2 - Biomedical Reports TI - Changes in renal function increase the need for advanced ventilatory support and increase the risk of mortality in critically ill patients with COVID‑19 UR - https://doi.org/10.3892/br.2022.1501 VL - 16 ER -