TY - JOUR AB - Injury to the peripheral nerve may lead to deficits in nerve function. An increase in the levels of free radicals plays a role in inhibition of nerve regeneration following damage. The aim of this study was to investigate the effects of lotus essential oil (LEO) on neurite outgrowth in vitro and nerve regeneration in vivo in a rat model of sciatic nerve crush injury. Gas chromatography‑mass spectrometry analysis showed that the principal constituent of LEO was palmitic acid ethyl ester (25.12%). The radical scavenging activity of LEO was evaluated using the DPPH method, and was determined to be IC50=29.01±2.93 µg/ml. LEO‑treated sensory neurons exhibited increased neurite outgrowth and upregulated levels of phospho‑ERK. Sensory and motor functions were improved in rats treated with 50 and 100 mg/kg LEO, and this was accompanied by an increase in the number of neurons in the dorsal root ganglia, as well as an increase in the nerve axon diameters following nerve injury. Taken together, these results suggests that LEO may serve as a novel pharmacological option for the management of peripheral nerve injury. AD - Division of Physiology, School of Medical Sciences, University of Phayao, Amphur Muang, Phayao 56000, Thailand The Unit of Excellence in Translational Neurosciences Initiative, University of Phayao, Amphur Muang, Phayao 56000, Thailand AU - Sriraksa,Napatr AU - Kongsui,Ratchaniporn AU - Thongrong,Sitthisak DA - 2022/04/01 DO - 10.3892/br.2022.1513 IS - 4 JO - Biomed Rep KW - Nelumbo nucifera lotus essential oil peripheral nerve injury functional recovery axon elongation PY - 2022 SN - 2049-9434 2049-9442 SP - 30 ST - Lotus essential oil improves neurite elongation and facilitates functional recovery after peripheral nerve injury T2 - Biomedical Reports TI - Lotus essential oil improves neurite elongation and facilitates functional recovery after peripheral nerve injury UR - https://doi.org/10.3892/br.2022.1513 VL - 16 ER -