TY - JOUR
AB - Craniocerebral injury (CBI) is tissue damage caused by a sudden mechanical force. CBI can result in neurological, neuropsychological and psychiatric dysfunctions. Currently, the severity of CBI is assessed using the Glasgow Coma Scale, brain perfusion pressure measurements, transcranial Doppler tests and biochemical markers. This study aimed to determine the applicability of the S‑100B protein levels and the time‑averaged mean maximum cerebral blood flow velocity (Vmean) as a means of predicting the treatment outcomes of CBI in the first 4 days of hospitalization. The results validated the standard reference ranges previously proposed for the concentration of S‑100B (0.05‑0.23 µg/l) and the mean of cerebral blood flow velocity (30.9 to 74.1 cm/sec). The following stratification scheme was used to predict the success of treatment: Patients with a Glasgow Outcome Scale (GOS) score ≥4 or GOS <4 were stratified into ‘favorable’ and ‘unfavorable’ groups, respectively. The favorable group showed relatively constant levels of the S‑100B protein close to the normal range and exhibited an increase in Vmean, but this was still within the normal range. The unfavorable group exhibited a high level of S‑100B protein and increased Vmean outside of the normal ranges. The changes in the levels of S‑100B in the unfavorable and favorable groups were ‑0.03 and ‑0.006 mg/l/h, respectively. Furthermore, the rate of decrease in the Vmean value in the unfavorable and favorable groups were ‑0.26 and ‑0.18 cm/sec/h, respectively. This study showed that constant levels of S‑100B protein, even slightly above the normal range, associated with an increase in Vmean was indicative of a positive therapeutic outcome. However, additional research is required to obtain the appropriate statistical strength required for clinical practice.
AD - Department of Neurosurgery, Postgraduate Medical Centre, 03‑242 Warsaw, Poland
Clinical Department of Neurosurgery, Central Clinical Hospital of the Ministry of the Interior and Administration, 02‑507 Warsaw, Poland
Faculty of Medical Sciences and Health Sciences, Kazimierz Pulaski University of Technology and Humanities Radom, 26‑600 Radom, Poland
AU - Dzierzęcki,Sebastian
AU - Ząbek,Mirosław
AU - Zaczyński,Artur
AU - Tomasiuk,Ryszard
DA - 2022/07/01
DO - 10.3892/br.2022.1541
IS - 1
JO - Biomed Rep
KW - S‑100B protein
mean maximum blood velocity
early diagnosis
cerebrospinal injury
PY - 2022
SN - 2049-9434
2049-9442
SP - 58
ST - Prognostic properties of the association between the S‑100B protein levels and the mean cerebral blood flow velocity in patients diagnosed with severe traumatic brain injury
T2 - Biomedical Reports
TI - Prognostic properties of the association between the S‑100B protein levels and the mean cerebral blood flow velocity in patients diagnosed with severe traumatic brain injury
UR - https://doi.org/10.3892/br.2022.1541
VL - 17
ER -