TY - JOUR AB - Protein arginine methyltransferases (PRMTs) are widely found in eukaryotes and regulate gene expression and post‑translational modifications. PRMT1‑PRMT6 have important roles in the pathology of cardiovascular diseases (CVDs), including atherosclerosis, heart failure and myocardial hypertrophy. Although these enzymes are also closely associated with various CVDs, the mechanisms of the involvement of PRMTs in the regulation of CVD have remained largely elusive. PRMTs methylate arginine residues and other factors. The present review describes the roles of PRMT1‑PRMT6 in CVD. Furthermore, the biological characteristics of PRMTs and mechanisms by which PRMTs regulate cholesterol metabolism are being introduced. This review aims to provide inspiration for cardiovascular drug research and offer clues for research on the pathogenesis of CVD. AD - Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi 541199, P.R. China Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541199, P.R. China AU - Zheng,Sisi AU - Zeng,Congcong AU - Huang,Ailing AU - Huang,Fuqi AU - Meng,Anna AU - Wu,Zhuan AU - Zhou,Shouhong DA - 2022/11/01 DO - 10.3892/br.2022.1572 IS - 5 JO - Biomed Rep KW - protein arginine methyltransferase atherosclerosis cholesterol metabolism heart failure cardiac hypertrophy PY - 2022 SN - 2049-9434 2049-9442 SP - 90 ST - Relationship between protein arginine methyltransferase and cardiovascular disease (Review) T2 - Biomedical Reports TI - Relationship between protein arginine methyltransferase and cardiovascular disease (Review) UR - https://doi.org/10.3892/br.2022.1572 VL - 17 ER -