TY - JOUR AB - The aim of the present study was to investigate the clinical features and laboratory parameters of hospitalized patients with coronavirus disease 2019 (COVID‑19) and assess the characteristics between severe and non‑severe cases. The study retrospectively analyzed the clinical data of 1,096 patients, of which, 626 (57.11%) and 470 (42.89%) were categorized into severe and non‑severe groups, respectively. Clinical parameters such as signs and symptoms, comorbidities, levels of D‑dimer, C‑reactive protein (CRP), interleukin 6 (IL‑6) and lactate dehydrogenase were analyzed. The data are presented as frequencies, means and standard deviations. The chi‑square test and Mann‑Whitney U test were used to assess any significant differences between the severe and non‑severe COVID‑19 groups. The clinical symptoms in severe COVID‑19 cases included anosmia (P≤0.01), sore throat (P≤0.01), fatigue (P≤0.01), headache (P≤0.01), and shortness of breath (P≤0.01). Laboratory findings showed a significant increase in CRP (21.90±40.23 vs. 16.13±21.82; P≤0.01) and IL‑6 levels (58.92±55.07 vs. 41.41±38.30; P≤0.01). Patients with severe COVID‑19 had significant lymphopenia compared with that in non‑severe cases. Among the comorbidities, hypertension (P≤0.01) was significantly more frequent in patients with severe COVID‑19. In conclusion, major derangements in laboratory parameters were observed in patients with severe COVID‑19 infection. AD - Department of Microbiology, Government Medical College, Srinagar, Jammu and Kashmir 190010, India Department of Pulmonary Medicine, Chest Disease Hospital, Government Medical College, Drugjan, Srinagar, Jammu and Kashmir 190001, India Department of Family and Community Medicine, College of Medicine, Jouf University, Sakaka, Al Jouf 70214, Kingdom of Saudi Arabia Department of Biochemistry, University of Kashmir, Srinagar, Jammu and Kashmir 190010, India Department of Surgery, SKIMS Medical College, Srinagar, Jammu and Kashmir 191101, India Department of Respiratory Medicine, Chest Disease Hospital, Government Medical College, Drugjan, Srinagar, Jammu and Kashmir 190010, India AU - Farhana,Anjum AU - Tantry,Bilal,Ahmad AU - Shah,Naveed,Nazir AU - Bandy,Altaf AU - Nabi,Mudasar AU - Khursheed,Syed,Quibtiya AU - Shahnawaz,Mir AU - Mustafa,Hena DA - 2022/12/01 DO - 10.3892/br.2022.1577 IS - 6 JO - Biomed Rep KW - coronavirus disease 2019 D‑dimer c‑reactive proteins interleukin 6 lactate dehydrogenase lymphopenia comorbidity and inflammation PY - 2022 SN - 2049-9434 2049-9442 SP - 94 ST - Clinical characteristics among patients with COVID‑19: A single‑center retrospective study T2 - Biomedical Reports TI - Clinical characteristics among patients with COVID‑19: A single‑center retrospective study UR - https://doi.org/10.3892/br.2022.1577 VL - 17 ER -