TY - JOUR AB - Huntington's disease (HD) is a neurodegenerative disorder characterized by severe motor, cognitive and psychiatric symptoms. Patients of all ages can present with a dysfunction of the nervous system, which leads to the progressive loss of movement control and disabilities in speech, swallowing, communications, etc. The molecular basis of the disease is well‑known, as HD is related to a mutated gene, a trinucleotide expansion, which encodes to the huntingtin protein. This protein is linked to neurogenesis and the loss of its function leads to neurodegenerative disorders. Although the genetic cause of the disorder has been known for decades, no effective treatment is yet available to prevent onset or to eliminate the progression of symptoms. Thus, the present review focused on the development of novel methods for the timely and accurate diagnosis of HD in an aim to aid the development of therapies which may reduce the severity of the symptoms and control their progression. The majority of the therapies include gene‑silencing mechanisms of the mutated huntingtin gene aiming to suppress its expression, and the use of various substances as drugs with highly promising results. In the present review, the latest approaches on the diagnosis of HD are discussed along with the need for genetic counseling and an up‑to‑date presentation of the applied treatments. AD - Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, 11855 Athens, Greece Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece University Research Institute of Maternal and Child Health and Precision Medicine, and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens, ‘Aghia Sophia’ Children's Hospital, 11527 Athens, Greece AU - Palaiogeorgou,Anastasia,Marina AU - Papakonstantinou,Eleni AU - Golfinopoulou,Rebecca AU - Sigala,Markezina AU - Mitsis,Thanasis AU - Papageorgiou,Louis AU - Diakou,Io AU - Pierouli,Katerina AU - Dragoumani,Konstantina AU - Spandidos,Demetrios,A. AU - Bacopoulou,Flora AU - Chrousos,George,P. AU - Eliopoulos,Elias AU - Vlachakis,Dimitrios DA - 2023/01/01 DO - 10.3892/br.2022.1587 IS - 1 JO - Biomed Rep KW - Huntington's disease neurodegenerative disorder huntingtin protein genetic counseling treatment PY - 2023 SN - 2049-9434 2049-9442 SP - 5 ST - Recent approaches on Huntington's disease (Review) T2 - Biomedical Reports TI - Recent approaches on Huntington's disease (Review) UR - https://doi.org/10.3892/br.2022.1587 VL - 18 ER -