TY - JOUR AB - Lead causes damage to the whole body by inducing oxidative stress. This includes the testis, in which spermatogenesis is affected. Etlingera elatior, a consumable plant that is being extensively studied for its high anti-oxidant properties, was tested against the effect of lead acetate in experimental rats. Rats were divided into groups consisting of a control, lead acetate only, Etlingera elatior treatment only, concurrent treatment of lead acetate and Etlingera elatior, post-treatment of lead acetate followed by Etlingera elatior and preventive group of Etlingera elatior followed by lead acetate. The substances were administered for 14 days and the effects were measured by protein carbonyl content (PCC), superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity in the testis, as well as the testosterone level in the serum. Histological changes in the testis were also observed. Results showed that Etlingera elatior induced a significant reduction in the testis PCC activity, while at the same time it significantly increased the activities of SOD and GPx in the testis, and the testosterone level in the serum. Etlingera elatior also improved the histology of the testis when compared to the lead acetate-treated group. On the whole, Etlingera elatior is effective against oxidative damage caused by lead acetate in the testis. AD - Department of Post Graduate Studies, Research Laboratory, International Medical University, Kuala Lumpur, Malaysia Department of Pathology, Faculty of Medicine, International Medical University, 57000 Kuala Lumpur, Malaysia Department of Human Biology, Faculty of Medicine, International Medical University, Kuala Lumpur, Malaysia Department of Pharmacy, International Medical University, Kuala Lumpur, Malaysia AU - Haw,Khor Yen AU - Chakravarthi,Srikumar AU - Haleagrahara,Nagaraja AU - Rao,Mallikarjuna DA - 2012/01/01 DO - 10.3892/etm.2011.355 EP - 104 IS - 1 JO - Exp Ther Med KW - lead Etlingera elatior oxidative stress spermatogenesis testis PY - 2012 SN - 1792-0981 1792-1015 SP - 99 ST - Effects of Etlingera elatior extracts on lead acetate-induced testicular damage: A morphological and biochemical study T2 - Experimental and Therapeutic Medicine TI - Effects of Etlingera elatior extracts on lead acetate-induced testicular damage: A morphological and biochemical study UR - https://doi.org/10.3892/etm.2011.355 VL - 3 ER -