TY - JOUR AB - Lead causes damage to the body by inducing oxidative stress. The sites of damage include the bone marrow, where marrow hypoplasia and osteosclerosis may be observed. Leaves of Carica papaya, which have antioxidant and haemopoietic properties, were tested against the effect of lead acetate in experimental rats. The rats were divided into 8 groups; control, lead acetate only, Carica papaya (50 mg and 200 mg), post‑treatment with Carica papaya (50 mg and 200 mg) following lead acetate administration and pre‑treatment with Carica papaya (50 mg and 200 mg) followed by lead acetate administration. The substances were administered for 14 days. The effects were evaluated by measuring protein carbonyl content (PCC) and glutathione content (GC) in the bone marrow. Histological changes in the bone marrow were also observed. The results showed that Carica papaya induced a significant reduction in the PCC activity and significantly increased the GC in the bone marrow. Carica papaya also improved the histology of the bone marrow compared with that of the lead acetate‑treated group. In summary, Carica papaya was effective against the oxidative damage caused by lead acetate in the bone marrow and had a stimulatory effect on haemopoiesis. AD - Faculty of Medicine, University of Queensland, Brisbane, Australia Department of Pathology, Faculty of Medicine, International Medical University, Kuala Lumpur, Malaysia Faculty of Physiology, James Cook University, Townsville, Australia Department of Community Medicine, Faculty of Medicine, International Medical University, Kuala Lumpur, Malaysia AU - Tham,Ching ,S. AU - Chakravarthi,Srikumar AU - Haleagrahara,Nagaraja AU - De Alwis,Ranjit DA - 2013/02/01 DO - 10.3892/etm.2012.851 EP - 652 IS - 2 JO - Exp Ther Med KW - lead acetate Carica papaya bone marrow haemopoiesis aplasia PY - 2013 SN - 1792-0981 1792-1015 SP - 648 ST - Morphological study of bone marrow to assess the effects of lead acetate on haemopoiesis and aplasia and the ameliorating role of Carica papaya extract T2 - Experimental and Therapeutic Medicine TI - Morphological study of bone marrow to assess the effects of lead acetate on haemopoiesis and aplasia and the ameliorating role of Carica papaya extract UR - https://doi.org/10.3892/etm.2012.851 VL - 5 ER -