TY - JOUR AB - Spinal cord injury (SCI) is a severe neurological disease. An effective strategy for the treatment of SCI is urgently required. Stem cell transplantation has emerged as a viable therapeutic option with great potential for restoring neurological function lost following SCI. From 2009 to 2010, a total of 20 SCI patients were enrolled in a clinical trial by Wuhan Hongqiao Brain Hospital; all patients completed and signed informed consent prior to autologous bone marrow‑derived mesenchymal stem cell transplantation. Analysis of subsequent treatment results indicated significant improvements in sensory, motor and autonomic nerve function as assessed by the American Spinal Injury Association's impairment scale. Thirty days after transplantation, a total of 15 patients (75%) demonstrated improvement, including four of the eight patients (50%) with grade A SCI, three of the four patients (75%) with grade B injury and all eight patients (100%) with grade C injury. The most common adverse events, fever and headache, disappeared within 24‑48 h without treatment. AD - Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China Biochemistry Institute, Wuhan University, Wuhan, Hubei 430071, P.R. China Blue Horizon International, LLC, New York, NY 10014, USA Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China AU - Jiang,Pu-Cha AU - Xiong,Wen-Ping AU - Wang,Ge AU - Ma,Chao AU - Yao,Wei-Qi AU - Kendell,Steven ,F. AU - Mehling,Brian ,M. AU - Yuan,Xian-Hou AU - Wu,Dong-Cheng DA - 2013/07/01 DO - 10.3892/etm.2013.1083 EP - 146 IS - 1 JO - Exp Ther Med KW - spinal cord injury autologous bone marrow‑derived mesenchymal stem cells human bone marrow-derived mesenchymal stem cells clinical trial PY - 2013 SN - 1792-0981 1792-1015 SP - 140 ST - A clinical trial report of autologous bone marrow‑derived mesenchymal stem cell transplantation in patients with spinal cord injury T2 - Experimental and Therapeutic Medicine TI - A clinical trial report of autologous bone marrow‑derived mesenchymal stem cell transplantation in patients with spinal cord injury UR - https://doi.org/10.3892/etm.2013.1083 VL - 6 ER -