TY - JOUR AB - Found in inflammatory zone 1 (FIZZ1) plays a vital role in pulmonary inflammation and angiogenesis. In addition, FIZZ1 plays a role in the early stages of airway remodeling in asthma by increasing the expression of α smooth muscle actin (α‑SMA) and type I collagen. However, the role of FIZZ1 in the airway remodeling of asthma remains unclear. In the present study, FIZZ1 was identified to be upregulated in ovalbumin (OVA)‑induced asthmatic mice, along with phosphorylated protein kinase B (Akt). Following FIZZ1 recombinant protein co‑culture in the murine lung epithelial‑cell line, Akt phosphorylation was upregulated, however, following transfection with FIZZ1‑small hairpin RNA, the phosphorylation levels were decreased. The variation in α‑SMA and type I collagen expression levels was consistent with the Akt phosphorylation levels. Intratracheal administration of LY294002 and Akt inhibitor IV to the asthmatic mice was capable of reducing airway inflammation, downregulating the expression of α‑SMA, type I collagen and fibronectin‑1 and increasing the expression of E‑cadherin. In conclusion, the present study demonstrated that FIZZ1 promoted airway remodeling in asthma via the phosphoinositide 3‑kinase (PI3K)/Akt signaling pathway. Blocking the PI3K/Akt signaling pathway may attenuate the early stages of airway remodeling induced by OVA by regulating the abnormal process of epithelial‑mesenchymal transition. AD - Department of Pulmonary Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China Department of Pulmonary Medicine, The Second Hospital of Shandong University, Jinan, Shandong 250100, P.R. China Institute of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China AU - Wang,Junfei AU - Li,Fei AU - Yang,Mengmeng AU - Wu,Jinxiang AU - Zhao,Jiping AU - Gong,Wenbin AU - Liu,Wen AU - Bi,Wenxiang AU - Dong,Liang DA - 2014/05/01 DO - 10.3892/etm.2014.1580 EP - 1270 IS - 5 JO - Exp Ther Med KW - asthma airway remodeling found in inflammatory zone 1 epithelial-mesenchymal transition phosphoinositide 3-kinase/protein kinase B signaling pathway PY - 2014 SN - 1792-0981 1792-1015 SP - 1265 ST - FIZZ1 promotes airway remodeling through the PI3K/Akt signaling pathway in asthma T2 - Experimental and Therapeutic Medicine TI - FIZZ1 promotes airway remodeling through the PI3K/Akt signaling pathway in asthma UR - https://doi.org/10.3892/etm.2014.1580 VL - 7 ER -