TY - JOUR AB - microRNA (miR)‑148a has been shown to act as an important suppressor in numerous human malignancies and is markedly downregulated in hepatocellular carcinoma; however, the role of miR‑148a in the regulation of hepatocellular carcinoma cell invasion, as well as the underlying mechanism, has never been studied. In the present study, the expression level of miR‑148a was found to be significantly decreased in hepatocellular carcinoma tissues and HepG2 cells when compared with that in the normal adjacent tissues. Furthermore, a novel target of miR‑148a was found, sphingosine‑1‑phosphate receptor 1 (S1PR1), whose expression was negatively regulated by miR‑148a at a post‑transcriptional level in hepatocellular carcinoma HepG2 cells. Upregulation of miR‑148a by transfection with miR‑148a mimics notably suppressed HepG2 cell invasion, similar to the effect of the SIPR1 downregulation induced by SIPR1‑specific small interfering RNA, while the restoration of S1PR1 expression reversed the inhibitory effect of miR‑148a upregulation on HepG2 cell invasion. Accordingly, the current study suggests that miR‑148a plays an inhibitory role in the regulation of hepatocellular carcinoma cell invasion by directly targeting S1PR1. AD - Department of Hepatobiliary Surgery, Linzi District People's Hospital, Zibo, Shandong 255400, P.R. China National Hepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China AU - Zhang,Shu‑Liang AU - Liu,Ling DA - 2015/02/01 DO - 10.3892/etm.2014.2137 EP - 584 IS - 2 JO - Exp Ther Med KW - hepatocellular carcinoma microRNA‑148a sphingosine‑1‑phosphate receptor 1 invasion PY - 2015 SN - 1792-0981 1792-1015 SP - 579 ST - microRNA-148a inhibits hepatocellular carcinoma cell invasion by targeting sphingosine-1‑phosphate receptor 1 T2 - Experimental and Therapeutic Medicine TI - microRNA-148a inhibits hepatocellular carcinoma cell invasion by targeting sphingosine-1‑phosphate receptor 1 UR - https://doi.org/10.3892/etm.2014.2137 VL - 9 ER -