TY - JOUR AB - Inflammatory bowel disease (IBD) is a chronic and progressive inflammatory condition of the gastrointestinal tract. Although the causative events that lead to the onset of IBD are yet to be fully elucidated, deregulation of immune and inflammatory mechanisms are hypothesized to significantly contribute to this disorder. Since the onset of IBD is often during infancy, in the present study, the serum values of a large panel of cytokines and chemokines in pediatric patients (<18 years; n=26) were compared with age‑matched controls (n=37). While elevations in the serum level of several proinflammatory and immune regulating cytokines were confirmed, such as interleukin (IL)‑1β, IL‑5, IL‑7, interferon (IFN)‑γ‑inducible protein‑10, IL‑16, cutaneous T‑cell‑attracting chemokine, leukemia inhibitory factor, monokine induced by γ‑IFN, IFN‑α2 and IFN‑γ, notably decreased levels of IL‑2, IL‑17 and macrophage inhibitory protein‑1β were also observed. Therefore, while a number of proinflammatory cytokines exhibit increased levels in IBD patients, pediatric IBD patients may also exhibit certain aspects of a reduced immunological response. AD - Department of Advanced Diagnostic and Clinical Trials, Institute for Maternal and Child Health - IRCCS ‘Burlo Garofolo’, Trieste 34137, Italy Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara 44121, Italy AU - Kleiner,Giulio AU - Zanin,Valentina AU - Monasta,Lorenzo AU - Crovella,Sergio AU - Caruso,Lorenzo AU - Milani,Daniela AU - Marcuzzi,Annalisa DA - 2015/06/01 DO - 10.3892/etm.2015.2370 EP - 2052 IS - 6 JO - Exp Ther Med KW - inflammatory bowel disease cytokines chemokines PY - 2015 SN - 1792-0981 1792-1015 SP - 2047 ST - Pediatric patients with inflammatory bowel disease exhibit increased serum levels of proinflammatory cytokines and chemokines, but decreased circulating levels of macrophage inhibitory protein-1β, interleukin-2 and interleukin-17 T2 - Experimental and Therapeutic Medicine TI - Pediatric patients with inflammatory bowel disease exhibit increased serum levels of proinflammatory cytokines and chemokines, but decreased circulating levels of macrophage inhibitory protein-1β, interleukin-2 and interleukin-17 UR - https://doi.org/10.3892/etm.2015.2370 VL - 9 ER -