TY - JOUR AB - The aim of the present study was to examine the effect of the traditional Chinese medicine Qili qiangxin on cardiomyocyte apoptosis following myocardial infarction (MI) in a rat model. MI was induced in rats by ligation of the anterior descending coronary artery. Survivors were randomly divided into the sham operation, MI, and Qili qiangxin groups (4 g/kg per day). After 28 days, infarction size was measured. In the non‑infarcted zones (NIZ), the apoptotic index (AI) was measured by terminal deoxynucleotidyl transferase (TdT)‑mediated digoxigenin‑conjugated dUTP nick‑end labeling (TUNEL). Expression of Fas was detected by immunohistochemistry, and the expression of xanthine oxidase (XO) and caspase‑3 by western blot analysis. In addition, the XO and ·O2‑, ·OH‑scavenging activity of myocardial tissue in NIZ was measured by colorimetry. Compared to the MI group, AI and the expression of Fas and caspase‑3 were significantly decreased in NIZ. The activity of XO was also considerably reduced while ·O2‑ and ·OH‑scavenging activity was significantly increased in the Qili qiangxin group. Ventricular remodeling was attenuated but there were no significant differences in infarct size (IS) or XO expression levels between the Qili qiangxin and MI groups. In conclusion, the results suggest that Qili qiangxin may inhibit cardiomyocyte apoptosis in NIZ in rats. The potential mechanism involved may be associated with its ability to reduce reactive oxygen species (ROS) and to depress the expression of Fas and caspase-3. AD - Department of Cardiology, Chongqing Medical Emergency Center, Chongqing 400014, P.R. China Department of Cardiology, The Second Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400010, P.R. China AU - Xiao,Jun AU - Deng,Song‑Bai AU - She,Qiang AU - Li,Jun AU - Kao,Guo‑Ying AU - Wang,Jun‑Sheng AU - Ma,Yu DA - 2015/11/01 DO - 10.3892/etm.2015.2759 EP - 1823 IS - 5 JO - Exp Ther Med KW - Qili qiangxin xanthine oxidase reactive oxygen species apoptosis myocardial infarction PY - 2015 SN - 1792-0981 1792-1015 SP - 1817 ST - Traditional Chinese medicine Qili qiangxin inhibits cardiomyocyte apoptosis in rats following myocardial infarction T2 - Experimental and Therapeutic Medicine TI - Traditional Chinese medicine Qili qiangxin inhibits cardiomyocyte apoptosis in rats following myocardial infarction UR - https://doi.org/10.3892/etm.2015.2759 VL - 10 ER -