TY - JOUR AB - Flavonoids have been demonstrated to have cytotoxic activities toward numerous human cancer cells, whereas they have little or no effect on normal cells. The numerous flavonoids in traditional Chinese herbs may be promising candidates for the development of novel anti‑cancer drugs. Our previous study demonstrated that CH2Cl2 and 95% ethanol eluate (EE) fractions have the strongest cytotoxic activities against human cancer cell lines of the 9 fractions separated from Artemisia sacrorum Ledeb., which is widely used to prevent and treat diverse diseases in Northeast China. In the present study, 8 flavonoids were isolated from the 95% EE fraction of Artemisia sacrorum Ledeb. The chemical structures of the compounds were elucidated by extensive spectroscopic analyses. The following 5 flavonoids were isolated for the first time from this plant: Jaceosidin, kaempferol, quercetin, luteolin and quercitrin. A total of 2 flavonoids from the CH2Cl2 fraction and 8 flavonoids from the 95% EE fraction were examined to evaluate their cytotoxic activities against human SK‑HEP‑1 hepatoma cancer cells and human HeLa cervical cancer cells, respectively. The results revealed that 2 flavonoids had marked cytotoxic activities against HeLa cells. AD - Department of Pharmacognosy, College of Pharmacy, Yanbian University, Yanji, Jilin 133000, P.R. China Department of Pharmacy, Jilin Central Hospital, Jilin, Jilin 132000, P.R. China AU - Yuan,Haidan AU - Lu,Xuyang AU - Ma,Qianqian AU - Li,Di AU - Xu,Guanghua AU - Piao,Guangchun DA - 2016/09/01 DO - 10.3892/etm.2016.3556 EP - 1878 IS - 3 JO - Exp Ther Med KW - Artemisia sacrorum Ledeb. flavonoids cytotoxic activities human cancer cell lines PY - 2016 SN - 1792-0981 1792-1015 SP - 1873 ST - Flavonoids from Artemisia sacrorum Ledeb. and their cytotoxic activities against human cancer cell lines T2 - Experimental and Therapeutic Medicine TI - Flavonoids from Artemisia sacrorum Ledeb. and their cytotoxic activities against human cancer cell lines UR - https://doi.org/10.3892/etm.2016.3556 VL - 12 ER -