TY - JOUR AB - The incidence of inflammatory bowel disease (IBD), characterized by chronic, relapsing intestinal inflammation, has continually increased in recent years. A previous study by our group identified five potential metabolic markers possibly associated with the pathology of 2,4,6-trinitrobenzenesulfonic acid (TNBS)‑induced IBD in rats. The present study aimed to examine the potential therapeutic effects of the essential oil of Pogostemon cablin (also known as patchouli; PO) on TNBS‑induced rats and investigate the concomitant metabolic changes by targeting the previously identified potential markers. Pogostemon cablin is widely used to treat gastrointestinal diseases, including IBD, in China. The results of the present study showed that PO (270 mg/kg, rectal instillation) significantly alleviated colonic damage and reduced disease activity indicators and colonic myeloperoxidase in TNBS‑induced rats. In addition, a targeted metabolic profiling study identified that four metabolites were elevated in the urine of the animals in the TNBS group, which were significantly inhibited by treatment with PO: Two tryptophan metabolites [4-(2-aminophenyl)-2,4-dioxobutanoic acid and 4,6-cihydroxyquinoline] and two gut microbial metabolites (phenylacetylglycine and p‑cresol glucuronide). Taken together, these findings suggested that PO ameliorated the symptoms of TNBS‑induced IBD and reversed the metabolic changes potentially associated with TNBS‑induced IBD in rats. AD - Department of Pharmacy, The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China Analysis Center of Shimadzu Enterprise Management (China) Co., Ltd., Guangzhou, Guangdong 510010, P.R. China School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, Hong Kong SAR, P.R. China AU - Yu,Xiuting AU - Yang,Guanghua AU - Jiang,Hua AU - Lin,Shuhai AU - Liu,Yuhong AU - Zhang,Xie AU - Zeng,Huifang AU - Su,Ziren AU - Huang,Song AU - Shen,Linlin AU - Zhang,Xiaojun DA - 2017/08/01 DO - 10.3892/etm.2017.4577 EP - 1192 IS - 2 JO - Exp Ther Med KW - patchouli oil 2 4 6‑trinitrobenzenesulfonic acid colitis targeted metabolomics tryptophan catabolites gut microbial metabolites PY - 2017 SN - 1792-0981 1792-1015 SP - 1184 ST - Patchouli oil ameliorates acute colitis: A targeted metabolite analysis of 2,4,6-trinitrobenzenesulfonic acid-induced rats T2 - Experimental and Therapeutic Medicine TI - Patchouli oil ameliorates acute colitis: A targeted metabolite analysis of 2,4,6-trinitrobenzenesulfonic acid-induced rats UR - https://doi.org/10.3892/etm.2017.4577 VL - 14 ER -