TY - JOUR AB - Hepatocellular carcinoma (HCC) is one of the most common malignant neoplasms worldwide, however the underlying mechanisms and gene signatures of HCC are unknown. In the present study the profile datasets of four cohorts were integrated to elucidate the pathways and candidate genes of HCC. The expression profiles GSE25097, GSE45267, GSE57957 and GSE62232 were downloaded from the Gene Expression Omnibus database, including 436 HCC and 94 normal liver tissues. A total of 185 differentially expressed genes (DEGs) were identified in HCC, including 92 upregulated genes and 92 downregulated genes. Gene ontology (GO) was performed, which revealed that the upregulated DEGs were primarily enriched in cell division, mitotic nuclear division, mitotic cytokinesis and G1/S transition of the mitotic cell cycle. Pathway enrichment was analyzed based on the Kyoto Encyclopedia of Genes and Genomes database to assess the functional relevance of DEGs. The most significant module was selected from protein‑protein interactions and 15 important hub genes were identified. The sub‑networks of hub genes were involved in cell division, p53 signaling, and T lymphotropic virus type I infection signaling pathways. In conclusion, the present study revealed that the identified DEG candidate genes may promote the understanding of the cause and molecular mechanisms underlying the development of HCC and that these candidates and signal pathways may be potential targets of clinical therapy for HCC. AD - Department of General Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, P.R. China Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, P.R. China AU - Xing,Tonghai AU - Yan,Tingmang AU - Zhou,Qiang DA - 2018/06/01 DO - 10.3892/etm.2018.6075 EP - 4942 IS - 6 JO - Exp Ther Med KW - hepatocellular carcinoma bioinformatical analysis differentially expressed genes PY - 2018 SN - 1792-0981 1792-1015 SP - 4932 ST - Identification of key candidate genes and pathways in hepatocellular carcinoma by integrated bioinformatical analysis T2 - Experimental and Therapeutic Medicine TI - Identification of key candidate genes and pathways in hepatocellular carcinoma by integrated bioinformatical analysis UR - https://doi.org/10.3892/etm.2018.6075 VL - 15 ER -