TY - JOUR AB - Food allergy prevalence has steadily increased worldwide over the past decades and immunotherapeutic treatment strategies are gaining attention. Human umbilical cord‑derived mesenchymal stem cells (hUC‑MSCs) exhibit similar immune regulatory properties to bone marrow‑derived MSCs. hUC‑MCSs can be prepared with fewer ethical constraints and are potential candidates for allergic disorder therapies. The current study aimed to investigate potential antiallergic properties of hUC‑MSCs in mice with ovalbumin (OVA)‑induced food allergy. Administration of hUC‑MSCs cells intraperitoneally combined with oral gavage of the culture medium significantly alleviated OVA‑induced diarrhea symptoms. Additionally, this treatment significantly decreased IgE levels and the percentage of T helper 2 cells in the blood, which were increased in mice with OVA‑induced food allergy. The mRNA levels of the inflammatory cytokines interleukin‑4 and tumor necrosis factor‑α, and inflammatory cell infiltration in mouse colons were significantly decreased in hUC‑MSCs‑treated animals compared with mice with OVA‑induced food allergy. Goblet cells were detected in colons of allergy‑induced mice and their numbers were reduced following treatment with hUC‑MSCs. In addition, treatment with hUC‑MSCs reestablished the gut flora. The results revealed that hUC‑MSCs may have a potential application in food allergy therapy. AD - Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China Department of Pathology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China AU - Yan,Nannan AU - Xu,Jie AU - Zhao,Chuanxiang AU - Wu,Yi AU - Gao,Fengwei AU - Li,Ci AU - Zhou,Wenhui AU - Xiao,Tengfei AU - Zhou,Xiaoming AU - Shao,Qixiang AU - Xia,Sheng DA - 2018/12/01 DO - 10.3892/etm.2018.6763 EP - 4456 IS - 6 JO - Exp Ther Med KW - food allergy mesenchymal stem cell colon T helper 2 cell immunotherapy IgE PY - 2018 SN - 1792-0981 1792-1015 SP - 4445 ST - Human umbilical cord‑derived mesenchymal stem cells ameliorate the enteropathy of food allergies in mice T2 - Experimental and Therapeutic Medicine TI - Human umbilical cord‑derived mesenchymal stem cells ameliorate the enteropathy of food allergies in mice UR - https://doi.org/10.3892/etm.2018.6763 VL - 16 ER -