TY - JOUR AB - The impact of magnolol on cerebral ischemic stroke in rats and the molecular mechanism were explored. Sprague-Dawley rat models were studied. Cerebral indexes, hematoxylin and eosin staining, TUNEL staining assay, reverse transcription-polymerase chain reaction (RT-PCR) and western blotting were applied. The cerebral index in model group was significantly higher than that in sham operation group, and the cerebral index was obviously decreased after magnolol administration. Inflammatory cells accumulated in the brain tissue of rats in the model group. Abundant apoptotic cells were produced in the model group, which was overtly improved after rats were given magnolol. RT-PCR and western blot analysis showed that expression of mRNA and protein of brain-derived neurotrophic factor (BDNF) were distinctly decreased in model group, and increased after rats were given magnolol; while mRNA and protein expression of Bcl-2-associated X protein (Bax) were significantly raised in model group, and reduced after rats were given magnolol. The results showed that there were statistically significant differences in expression of BDNF and Bax among sham operation, model and magnolol administration groups (p<0.01). In conclusion, magnolol can increase the expression of BDNF and decrease the expression of Bax, thereby inhibiting apoptosis to protect the nerves, and magnolol can improve cerebral ischemic stroke in rats. AD - The Second Department of Neurosurgery, Xingtai People's Hospital, Xingtai, Hebei 054031, P.R. China Department of Neurosurgery, Tongchuan People's Hospital, Tongchuan, Shaanxi 727000, P.R. China Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, Shandong 252004, P.R. China Department of Neurosurgery, Taian City Central Hospital, Taian, Shandong 271000, P.R. China AU - Liu,Zhenbo AU - Xie,Jun AU - Lin,Kai AU - Qi,Liguo DA - 2018/12/01 DO - 10.3892/etm.2018.6807 EP - 4428 IS - 6 JO - Exp Ther Med KW - magnolol cerebral ischemic stroke BDNF Bax PY - 2018 SN - 1792-0981 1792-1015 SP - 4423 ST - Influencing mechanism of magnolol on expression of BDNF and Bax in rats with cerebral ischemic stroke T2 - Experimental and Therapeutic Medicine TI - Influencing mechanism of magnolol on expression of BDNF and Bax in rats with cerebral ischemic stroke UR - https://doi.org/10.3892/etm.2018.6807 VL - 16 ER -