TY - JOUR AB - Mesenchymal stem cells (MSCs) have been extensively investigated in the field of regenerative medicine. Human bone MSCs (BMSCs) have become a common type of seed cell for bone tissue engineering. However, the viability and cell number of BMSCs are negatively correlated with donor age, and as the extraction process is painful, this method has not been widely used. As human umbilical cord MSCs (UCMSCs) may be harvested inexpensively and inexhaustibly, the present study evaluated and compared the regenerative potential of UCMSCs and BMSCs to determine whether UCMSCs may be used as a novel cell type for bone regeneration. In the present study, the proliferation and osteogenic capacity of BMSCs and UCMSCs was compared in vitro. BMSCs and UCMSCs were respectively combined with biofunctionalized macroporous calcium phosphate cement, and their bone regenerative potentials were determined by investigating their capacity for ectopic bone formation in a nude mouse model as well as their efficacy in a rat model of tibia bone defect. The extent of bone regeneration was examined by X‑ray, histological and immunohistochemical analyses. The results revealed that UCMSCs exhibited a good osteogenic differentiation potential, similarly to that of BMSCs, and that UCMSCs were able to contribute to the regeneration of bone and blood vessels. Furthermore, no significant differences were identified between BMSCs and UCMSCs in terms of their bone regenerative effect. AD - Institute of Biomedical Science, Tianjin Kang Ting Biological Engineering Co., Ltd., Tianjin 300385, P.R. China AU - Wang,Qian AU - Zhao,Gang AU - Xing,Zijun AU - Zhan,Juming AU - Ma,Jie DA - 2019/01/01 DO - 10.3892/etm.2018.6975 EP - 772 IS - 1 JO - Exp Ther Med KW - bone marrow mesenchymal stem cells umbilical cord mesenchymal stem cells bone defect calcium phosphate cement osteogenic differentiation PY - 2019 SN - 1792-0981 1792-1015 SP - 764 ST - Comparative evaluation of the osteogenic capacity of human mesenchymal stem cells from bone marrow and umbilical cord tissue T2 - Experimental and Therapeutic Medicine TI - Comparative evaluation of the osteogenic capacity of human mesenchymal stem cells from bone marrow and umbilical cord tissue UR - https://doi.org/10.3892/etm.2018.6975 VL - 17 ER -