TY - JOUR AB - Delayed encephalopathy after acute carbon mono­xide poisoning (DEACMP) is a serious complication that occurs several days or weeks after carbon monoxide (CO) intoxication. This study identified computed tomography (CT) findings in the prediction of DEACMP development. Adults with CO poisoning admitted to Beijing Chaoyang Hospital, Shenyang Ninth People's Hospital, Shanxi Second People's Hospital and Shandong Provincial Hospital in China from January 2013 to January 2016 were retrospectively analyzed. Baseline demographic and clinical characteristics were extracted from the medical records. Brain CT imaging was carried out within 24 h of admission, and an integrated CT score was calculated to semi‑quantify lesion severity. Patients were followed‑up for 6 months. Baseline characteristics and CT findings were compared among patients who developed DEACMP (DEACMP group) and those who did not (non‑DEACMP group). The receiver operating characteristic (ROC) curve analysis was used to examine the utility of integrated CT score for predicting DEACMP. Among the 123 patients included in the analysis, 27 (22.0%) developed DEACMP. The DEACMP and non‑DEACMP groups did not differ with regard to age, sex and carboxyhemoglobin (COHb) level at admission. However, compared with the non‑DEACMP group, the patients in the DEACMP group had longer onset time of symptoms and duration of exposure to CO, higher acute physiology and chronic health evaluation‑II (APACHE‑II) score, lower Glasgow Coma Scale (GCS) score, and there was a higher proportion of patients with severe symptoms and brain CT abnormalities (81.5 vs. 51.0%; P<0.05). Integrated CT score in the DEACMP group was significantly higher than that in the non‑DEACMP group (73.63 vs. 51.39; P<0.01). ROC curve was used to analyze the utility of integrated CT score in the prediction of DEACMP. The area under the ROC curve was 0.700 (95% confidence interval, 0.584‑0.817; P<0.01). In conclusion, brain integrated CT score has the potential to identify DEACMP in patients. AD - Department of Occupational Medicine and Toxicology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China Shenyang Ninth People's Hospital, Shenyang, Liaoning 110024, P.R. China Shanxi Second People's Hospital, Taiyuan, Shanxi 030012, P.R. China Chinese Center for Disease Control and Prevention, Beijing 100050, P.R. China Shandong Provincial Hospital, Jinan, Shandong 250021, P.R. China Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China AU - Du,Xuqin AU - Gu,Hua AU - Hao,Fengtong AU - Gao,Lin AU - Wang,Jianru AU - Sun,Chengye AU - Zhang,Hongshun AU - Ma,Peibin AU - Zhang,Xingguo AU - Hu,Wenli DA - 2019/04/01 DO - 10.3892/etm.2019.7233 EP - 2688 IS - 4 JO - Exp Ther Med KW - acute carbon monoxide poisoning risk factor delayed encephalopathy after acute carbon monoxide poisoning computed tomography PY - 2019 SN - 1792-0981 1792-1015 SP - 2682 ST - Utility of brain CT for predicting delayed encephalopathy after acute carbon monoxide poisoning T2 - Experimental and Therapeutic Medicine TI - Utility of brain CT for predicting delayed encephalopathy after acute carbon monoxide poisoning UR - https://doi.org/10.3892/etm.2019.7233 VL - 17 ER -