TY - JOUR AB - This study investigated the efficacy of transplantation of allogeneic adipose-derived stem cells (ADMSCs) in rats with knee osteoarthritis (KOA) and the effect on the expression of matrix metalloproteinase 13 (MMP-13) and discoid domain receptor 2 (DDR2). In total, sixty rats were randomly selected. Eleven rats were selected as the blank group. Forty-four rat KOA models were established, and the remaining 5 rats were used for stem cell extraction. The rats were randomly divided into two groups, and the transplantation group was treated with ADMSCs transplantation. The KOA group was intragastrically administered with saline. The expressions of MMP-13 mRNA and DDR2 in rats were detected by RT-qPCR and immunohistochemistry. Correlation analysis was performed in MMP-13 mRNA and DDR2 expression levels in the KOA rats. After treatment, the indexes of Lequesne MG knee joints, MMP-13 mRNA and DDR2 in the transplanted rats were significantly lower than those in the KOA group (P<0.05). In the KOA rats, MMP-13 mRNA and DDR2 was positively correlated (r=0.830, P<0.001). Therefore, the transplantation of ADMSCs has a significant effect on the KOA rats, which can effectively improve the knee joint function of KOA rats and reduce the expression of MMP-13 mRNA and DDR2 in rats, and it is worthy of clinical promotion. AD - Department of Traumatology, Shanghai East Hospital Tongji University, Shanghai 200123, P.R. China Department of Preventive Medicine, Army Medical University, Chongqing 400038, P.R. China Department of Dermatology, Chongqing Medical University, Chongqing 400016, P.R. China AU - Li,Jianrui AU - Zhu,Xiaobo AU - Shao,Qin AU - Xu,Feini AU - Sun,Guixin DA - 2019/07/01 DO - 10.3892/etm.2019.7554 EP - 104 IS - 1 JO - Exp Ther Med KW - allogeneic adipose stem cells knee osteoarthritis ani­‑ mal model matrix metalloproteinase 13 Discoid domain receptor 2 PY - 2019 SN - 1792-0981 1792-1015 SP - 99 ST - Allogeneic adipose-derived stem cell transplantation on knee osteoarthritis rats and its effect on MMP-13 and DDR2 T2 - Experimental and Therapeutic Medicine TI - Allogeneic adipose-derived stem cell transplantation on knee osteoarthritis rats and its effect on MMP-13 and DDR2 UR - https://doi.org/10.3892/etm.2019.7554 VL - 18 ER -