TY - JOUR AB - Staple‑line bleeding and leakage is a life‑threatening complication in obese patients following laparoscopic sleeve gastrectomy. The aim of this study was to examine the potential effects of Ankaferd blood stopper (ABS) and Fibrin Sealant (FS; Tisseel®) on sleeve gastrectomy staple‑line healing in an experimental animal model. A total of 30 Wistar albino female rats were divided into three groups and were subjected to sleeve gastrectomy with linear stapling. Group A (control group) had nothing administered, Group B was administered FS on the staple‑line, and Group C was administered ABS on the staple‑line following sleeve gastrectomy. After sacrifice on postoperative day 5, anastomotic burst pressure, tissue hydroxyproline levels and histopathological parameters were measured. The results revealed that group C had the highest mean bursting pressure level. However, the values of this parameter were not found to differ significantly between the groups (P>0.05). Group B and C had a similar hydroxyproline levels but increased compared with group A (P<0.001). Histopathological parameters were similar between the groups, except macrophage scores in group C. In the present experimental study, ABS was demonstrated to improve gastric‑sleeved staple‑line healing compared with FS. ABS may be used as a novel reinforcement agent in bariatric surgery. AD - Department of General Surgery, Kepez State Hospital, Antalya 17110, Turkey Department of General Surgery, School of Medicine, VM Mersin Medical Park Hospital, Istinye University, Mersin 33200, Turkey Department of General Surgery, Antalya Training and Research Hospital, Antalya 07010, Turkey AU - Sakar,Alkan AU - Bilecik,Tuna AU - Mayir,Burhan AU - Oruç,Tahir DA - 2019/10/01 DO - 10.3892/etm.2019.7842 EP - 2523 IS - 4 JO - Exp Ther Med KW - obesity laparoscopic sleeve gastrectomy Ankaferd blood stopper fibrin sealent PY - 2019 SN - 1792-0981 1792-1015 SP - 2519 ST - The potential effects of Ankaferd blood stopper and fibrin sealent on sleeve gastrectomy staple‑line healing: An experimental study T2 - Experimental and Therapeutic Medicine TI - The potential effects of Ankaferd blood stopper and fibrin sealent on sleeve gastrectomy staple‑line healing: An experimental study UR - https://doi.org/10.3892/etm.2019.7842 VL - 18 ER -